A5070846875- Mesenchymal stem cell research
- Extracellular vesicles in disease
- dental development and anomalies
- Sulfur Compounds in Biology
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Bone Metabolism and Diseases
- Cancer-related molecular mechanisms research
- Oral and Maxillofacial Pathology
- Immune Response and Inflammation
- Bone and Dental Protein Studies
- Oral microbiology and periodontitis research
- Immune cells in cancer
- Hydrogen's biological and therapeutic effects
- Regulation of Appetite and Obesity
- Osteoarthritis Treatment and Mechanisms
- Nanoplatforms for cancer theranostics
- Phagocytosis and Immune Regulation
- Fibroblast Growth Factor Research
- Periodontal Regeneration and Treatments
- Inflammatory mediators and NSAID effects
- interferon and immune responses
- Wound Healing and Treatments
- RNA Research and Splicing
Peking University
2015-2025
Stomatology Hospital
2017-2025
Hefei University of Technology
2024-2025
Henan University of Science and Technology
2025
Peking University People's Hospital
2024
National Clinical Research Center for Digestive Diseases
2020-2024
Yancheng Institute of Technology
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Beijing Haidian Hospital
2022-2023
King University
2020-2023
Gaseous signaling molecules such as hydrogen sulfide (H2S) are produced endogenously and mediate effects through diverse mechanisms. H2S is one gasotransmitters that regulates multiple pathways in mammalian cells, abnormal metabolism has been linked to defects bone homeostasis. Here, we demonstrate marrow mesenchymal stem cells (BMMSCs) produce order regulate their self-renewal osteogenic differentiation, deficiency results BMMSC differentiation. causes aberrant intracellular Ca(2+) influx...
Abstract Streptococcus pneumoniae is a Gram-positive, extracellular bacterium that responsible for significant mortality and morbidity worldwide. Pneumolysin (PLY), cytolysin produced by all clinical isolates of the pneumococcus, one most important virulence factors this pathogen. We have previously reported PLY an essential factor activation caspase-1 consequent secretion IL-1β IL-18 in macrophages infected with S. pneumoniae. However, host molecular involved are still unclear. To further...
Mechanical force–induced orthodontic root resorption is a major clinical challenge in treatment. Macrophages play an important role resorption, but the underlying mechanism remains unclear. In this study, we examined by which ratio of M1 to M2 macrophage polarization affects during tooth movement. Root occurred when nickel–titanium coil springs were applied on upper first molars rats for 3 14 d. Positively stained odontoclasts or osteoclasts with tartrate-resistant acid phosphatase found...
Abstract Ten-eleven translocation (Tet) family-mediated DNA oxidation represents an epigenetic modification capable of converting 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC), which regulates various biological processes. However, it is unknown whether Tet family affects mesenchymal stem cells (MSCs) or the skeletal system. Here we show that depletion Tet1 and Tet2 results in impaired self-renewal differentiation bone marrow MSCs (BMMSCs) a significant osteopenia phenotype....
Abstract Bone marrow mesenchymal stem cells (MSCs) have demonstrated therapeutic effects for colitis through immunomodulation and anti-inflammation. However, whether MSC-derived exosomes possessed the similar function remains unclear. In present study, were isolated from control IFN-γ-primed MSCs was verified by transmission electron microscope (TEM) immunofluorescence staining. Administration of to mice significantly improved disease activity index histological score colitis, decreased...
The immune system plays a pivotal role during bone remodeling process. Orthodontic tooth movement (OTM) induces local inflammation in periodontium, but whether systemic response is involved OTM remains unknown. In this study, we show that distance was significantly reduced T-cell–deficient immunocompromised mice compared with wild-type (WT) mice. Intravenous infusion of allogeneic T cells to the rescued distance. Correspondingly, increased numbers tartrate-resistant acid phosphatase...
Mesenchymal stem cells (MSCs) influence T in health, disease and therapy through messengers of intercellular communication including extracellular vesicles (EVs). Apoptosis is a mode cell death that tends to promote immune tolerance, large number apoptotic (apoVs) are generated from MSCs during apoptosis. In an effort characterize these apoVs explore their immunomodulatory potential, here we show after replenishing them systemically, the apoV deficiency Fas mutant mice pathological...
Exosomes play a critical role in intracellular communication. The biogenesis and function of exosomes are regulated by multiple biochemical factors. In the present study, we find that mechanical force promotes derived from periodontal ligament stem cells (PDLSCs) alters exosomal proteome profile to induce osteoclastic differentiation. Mechanistically, increases level proteins, especially annexin A3 (ANXA3), which facilitates exosome internalization activate extracellular signal-regulated...
Bone defects caused by trauma or tumor led to high medical costs and poor life quality for patients. The exosomes, micro vesicles of 30-150 nm in diameter, derived from macrophages manipulated bone regeneration. However, the role hydrogen sulfide (H2S) biogenesis function exosomes its effects on regeneration remains elusive. In this study, we used H2S slow releasing donor GYY4137 stimulate found that promoted polarization M2 increase MSCs vitro vivo. Moreover, developed pre-treated...
Abstract Activating autologous stem cells after the implantation of biomaterials is an important process to initiate bone regeneration. Although several studies have demonstrated mechanism biomaterial‐mediated regeneration, a comprehensive single‐cell level transcriptomic map revealing influence on regulating temporal and spatial expression patterns mesenchymal (MSCs) still lacking. Herein, osteoimmune microenvironment depicted around classical collagen/nanohydroxyapatite‐based repair...
The bone remodeling during orthodontic treatment for malocclusion often requires a long duration of around two to three years, which also may lead some complications such as alveolar resorption or tooth root resorption. Low-intensity pulsed ultrasound (LIPUS), noninvasive physical therapy, has been shown promote fracture healing. It is reported that LIPUS could reduce the treatment; however, how regulates metabolism process still unclear.
The sympathetic nervous system (SNS) regulates bone resorption through β-2 adrenergic receptor (Adrb2). In orthodontic tooth movement (OTM), mechanical force induces and alveolar remodeling. Compressive force-associated osteoclast differentiation are the rate-limiting steps of movement. However, whether can activate Adrb2 thus contribute to OTM remains unknown. this study, nickel-titanium springs were applied upper first molars rats Adrb1/2(-/-) mice confirm role SNS in OTM. results showed...
Mesenchymal-stem-cell-based regenerative medicine is a promising approach for functional tissue reconstruction. A recent study showed that host immune cells regulated bone marrow mesenchymal stem cell (BMMSC)-mediated regeneration. However, it unknown whether systemic infusion of BMMSCs, which induces tolerance, affects cell-based In this study, we BMMSCs possessed an immunomodulatory function in vitro. Moreover, reduced IFN-γ and TNF-α levels the implantation sites via upregulation...
Hydrogen sulfide (H2S), a gasotransmitter, has been recently linked to mesenchymal stem cell (MSC) function and bone homeostasis. Periodontal ligament cells (PDLSCs) are the main MSCs in PDL, which respond mechanical force induce physiological activities during orthodontic tooth movement (OTM). However, it is unknown whether might endogenous H2S production by PDLSCs regulate alveolar Here, we used mouse OTM model demonstrate that force-induced PDL tissue was associated with macrophage...
The complex interaction between extracellular matrix and cells makes the design of materials for dental regeneration challenging. Chemical composition is an important characteristic biomaterial surfaces, which plays essential role in modulating adhesion function cells. effect different chemical groups on directing fate human pulp stem (hDPSCs) was thus explored our study. A range self-assembled monolayers (SAMs) with amino (−NH2), hydroxyl (−OH), carboxyl (−COOH), methyl (−CH3) modifications...
ATX has protective effects on intestinal mucosal dysfunction in Cy-induced immunodeficient mice.