A5089438461- Mesenchymal stem cell research
- T-cell and B-cell Immunology
- MicroRNA in disease regulation
- Inflammatory Myopathies and Dermatomyositis
- Extracellular vesicles in disease
- Cancer Immunotherapy and Biomarkers
- interferon and immune responses
- Immune Cell Function and Interaction
- Phagocytosis and Immune Regulation
- CAR-T cell therapy research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Long-Term Effects of COVID-19
- Virology and Viral Diseases
- Reproductive tract infections research
- Venomous Animal Envenomation and Studies
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Muscle and Compartmental Disorders
- RNA regulation and disease
- Cellular transport and secretion
- Reproductive System and Pregnancy
- Systemic Sclerosis and Related Diseases
Brigham and Women's Hospital
2019-2025
Harvard University
2021-2025
Renji Hospital
2021-2024
University of Pennsylvania
2018-2024
Shanghai Jiao Tong University
2022-2024
Cedars-Sinai Medical Center
2024
Johns Hopkins Medicine
2024
Johns Hopkins University
2024
California University of Pennsylvania
2024
Sichuan University
2022
T cell-derived pro-inflammatory cytokines are a major driver of rheumatoid arthritis (RA) pathogenesis. Although these have traditionally been attributed to CD4 cells, we found that CD8 cells notably abundant in synovium and make more interferon (IFN)-γ nearly as much tumor necrosis factor (TNF) their cell counterparts. Furthermore, using unbiased high-dimensional single-cell RNA-seq flow cytometric data, the vast majority synovial tissue fluid belong an effector population characterized by...
Immune checkpoint inhibitor (ICI) therapies used to treat cancer, such as anti–PD-1 antibodies, can induce autoimmune conditions in some individuals. The T cell mechanisms mediating iatrogenic autoimmunity and their overlap with spontaneous diseases remain unclear. Here, we compared cells from the joints of 20 patients an inflammatory arthritis induced by ICI therapy (ICI-arthritis) two archetypal arthritides, rheumatoid (RA) psoriatic (PsA). Single-cell transcriptomic antigen receptor...
Mesenchymal stem cells (MSCs) influence T in health, disease and therapy through messengers of intercellular communication including extracellular vesicles (EVs). Apoptosis is a mode cell death that tends to promote immune tolerance, large number apoptotic (apoVs) are generated from MSCs during apoptosis. In an effort characterize these apoVs explore their immunomodulatory potential, here we show after replenishing them systemically, the apoV deficiency Fas mutant mice pathological...
Mesenchymal stem cells (MSCs) closely interact with the immune system, and they are known to secrete inflammatory cytokines in response stress stimuli. The biological function of MSC-derived remains elusive. Here, we reveal that even under physiological conditions, MSCs produce release a low level tumor necrosis factor alpha (TNFα), which is unexpectedly required for preserving self-renewal differentiation via autocrine/paracrine signaling. Furthermore, TNFα critically maintains MSC vivo...
Abstract Pathologic T cell-B cell interactions drive disease in systemic lupus erythematosus (SLE). The cells that activate B responses include peripheral helper (Tph) and follicular (Tfh) cells, yet the developmental clonal relationships between these cell-helper populations are unclear. Here we use receptor (TCR) profiling to demonstrate overlap Tph Tfh circulation of patients with SLE. Expanded clones persist over course 1 year a new diagnosis SLE, observed shift both from time. High...
Objective Amyopathic dermatomyositis (ADM) is a heterogeneous and life‐threatening autoimmune disease with high mortality rate. In particular, anti–melanoma differentiation–associated protein 5 antibody–positive patients are at risk of developing rapidly progressive interstitial lung (RPILD). This study was undertaken to identify immunologic signatures among who have ADM ILD (ADM‐ILD) discover the biomarkers predicting prognosis. Methods The landscape 42 immune cell phenotypes in peripheral...
Abstract The study of neuroimmune crosstalk and the involvement neurotransmitters in inflammation bone health has illustrated their significance joint-related conditions. One important mode cell-to-cell communication synovial fluid (SF) is through extracellular vesicles (EVs) carrying microRNAs (miRNAs). role neurotransmitter receptors pathogenesis inflammatory joint diseases, whether there are specific miRNAs regulating differentially expressed HTR2A, contributing to processes metabolism...
Mesenchymal stem cell transplantation (MSCT) has been applied to treat a variety of autoimmune and inflammatory diseases. Psychosocial stress can aggravate disease progression in chronic patients. Whether psychological affects MSCT is largely unknown. In this study we show that attenuates therapeutic effects DSS-induced colitis mouse model by elevating the levels exosomal Mir7k/mmu-let-7 k (microRNA 7 k) circulation. Mechanistically, Mir7k inhibits STAT3 pathway donor MSCs, leading...
T cells contribute to tissue injury in systemic sclerosis (SSc), yet the specific cell subsets expanded patients with SSc remain incompletely defined. Here we evaluated phenotypes and functions of peripheral helper (Tph) follicular (Tfh) cells, which have been implicated autoantibody production, assessed their associations clinical features a well-characterized cohort SSc.
<title>Abstract</title> Apoptotic vesicles (apoVs) play a vital role in various pathological conditions; however, we have yet to fully understand their precise biological effects rescuing impaired mesenchymal stem cells (MSCs) and regulating tissue homeostasis. Here, proved that systemic infusion of bone marrow MSCs derived from wild-type (WT) mice effectively improved the osteopenia phenotype hyperimmune state ovariectomized (OVX) mice. Importantly, WT rescued impairment OVX both <italic>in...
Abstract Mesenchymal stem cells (MSCs) are a type of immunosuppressive stromal cell found in multiple tissues and organs. However, whether MSCs possess immunosupportive characteristics remains unclear. In this study, we showed that the lymph nodes contain MSCs. They produce secrete high level MCP-1 to promote T-cell proliferation differentiation, contrast bone marrow (BMMSCs), which repress activation. Unlike BMMSCs, node (LNMSCs) fail respond activated T-cell-induced production PD-L1 induce...
Abstract Immune checkpoint inhibitor (ICI) therapies that promote T cell activation have improved outcomes for advanced malignancies yet also elicit harmful autoimmune reactions. The mechanisms mediating these iatrogenic events remain unclear. Here we assayed cells from joints of patients affected by ICI-induced inflammatory arthritis (ICI-arthritis), which can present clinically indistinguishable rheumatoid (RA). Compared to the arthritides RA and psoriatic (PsA), ICI-arthritis contained an...
Background Data with fine granularity about COVID-19-related outcomes and risk factors were still limited in the idiopathic inflammatory myopathies (IIMs) population. This study aimed to investigate clinical associated hospitalized severe COVID-19 patients IIMs, particularly those gauged by myositis-specific antibodies. Methods retrospective cohort was conducted Renji IIM Shanghai, China, under an upsurge of SARS-CoV-2 omicron variant infections from December 2022 January 2023. Clinical data...
Summary Apoptosis is an integral physiological cell death process that occurs frequently and generates a huge number of apoptotic extracellular vesicles (apoEVs). However, whether apoEVs are necessary for maintaining organ homeostasis remains unclear. Here, we show circulatory engraft in liver undergo specialized internalization by hepatocytes (HCs) based on surface signature galactose N -acetylgalactosamine. Furthermore, rescue injury apoptotic-deficient Fas mutant Caspase-3 knockout mice,...