A5042099602- Restless Legs Syndrome Research
- Parkinson's Disease Mechanisms and Treatments
- Sleep and Wakefulness Research
- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Sleep and related disorders
- Neurological disorders and treatments
- Acute Ischemic Stroke Management
- Cardiovascular and Diving-Related Complications
- Stroke Rehabilitation and Recovery
- Sleep and Work-Related Fatigue
- Heart Rate Variability and Autonomic Control
- Migraine and Headache Studies
- Botulinum Toxin and Related Neurological Disorders
- Cardiovascular Disease and Adiposity
- COVID-19 and healthcare impacts
- Genetic Neurodegenerative Diseases
- Cerebrovascular and Carotid Artery Diseases
- Child Nutrition and Feeding Issues
- Suicide and Self-Harm Studies
- Adipose Tissue and Metabolism
- Geriatric Care and Nursing Homes
- Cardiovascular Syncope and Autonomic Disorders
- Psychosomatic Disorders and Their Treatments
- Transcranial Magnetic Stimulation Studies
Yale University
2016-2025
VA Connecticut Healthcare System
2015-2025
United States Department of Veterans Affairs
2025
Connecticut Health Foundation
2024
Yale New Haven Hospital
2024
Korea National Institute of Health
2024
Hudson Institute
2024
John Wiley & Sons (United States)
2024
Kyushu Institute of Technology
2024
Osaka University
2024
Background Obstructive sleep apnoea (OSA) is a heterogeneous disorder, and improved understanding of physiologic phenotypes their clinical implications needed. We aimed to determine whether routine polysomnographic data can be used identify OSA (clusters) assess the associations between cardiovascular outcomes. Methods Cross-sectional longitudinal analyses multisite, observational US Veteran (n=1247) cohort were performed. Principal components-based clustering was features in OSA’s four...
Periodic limb movements during sleep (PLMS) cause repetitive sympathetic activation and may be associated with increased cardiovascular risk. We hypothesized that PLMS frequency (periodic movement index [PLMI]) arousal [PLMAI]) are predictive of incident disease, including coronary heart peripheral arterial cerebrovascular in an elderly male cohort.
Journal Article Does poor sleep quality affect skin ageing? Get access P. Oyetakin‐White, Oyetakin‐White Department of DermatologyUniversity Hospitals Case Medical Center Cleveland OHUSA Search for other works by this author on: Oxford Academic Google Scholar A. Suggs, Suggs B. Koo, Koo Pulmonary and Sleep Medicine University OH USA M. S. Matsui, Matsui Estee Lauder Companies Inc Melville NY D. Yarosh, Yarosh K. Cooper, Cooper E. Baron Correspondence: Dr Elma Baron, Dermatology, 11100 Euclid...
This guideline establishes clinical practice recommendations for Treatment of Restless Legs Syndrome (RLS) and Periodic Limb Movement Disorder (PLMD) in adults pediatric patients.
Background: Restless legs syndrome (RLS) is a common sensorimotor disorder whose incidence not known.The aim of the study was to determine and correlates RLS in population-based sample.Methods: We obtained data from Tucson Cohort Sleep Heart Health Study, prospective multicenter study.This cohort included 535 participants aged ≥ 40 years, who answered questions regarding on 2002 2006 sleep surveys.For this study, defi ned as presence all 4 International Study Group criteria, with symptoms...
In rodent models, obesity and hyperglycemia alter cerebral glucose metabolism transport into the brain, resulting in disordered function as well inappropriate responses to homeostatic hedonic inputs. Whether similar findings are seen human brain remains unclear. this study, 25 participants (9 healthy participants; 10 obese nondiabetic 6 poorly controlled, insulin- metformin-treated type 2 diabetes mellitus (T2DM) participants) underwent 1H magnetic resonance spectroscopy scanning occipital...
To determine whether sleep-disordered breathing (SDB) is associated with cardiac arrhythmia in a clinic-based population multiple cardiovascular comorbidities and severe SDB.This was cross-sectional analysis of 697 veterans who underwent polysomnography for suspected SDB. SDB categorized according to the apnea-hypopnea index (AHI): none (AHI < 5), mild (5 ≥ AHI 15), moderate-severe 15). Nocturnal arrhythmias consisted of: (1) complex ventricular ectopy, (CVE: non-sustained tachycardia,...
Determine the prevalence of, and clinical features associated with, a low respiratory arousal threshold (ArTH) among patients with obstructive sleep apnea (OSA), to assess whether ArTH is reduced long-term CPAP use.Cross-sectional longitudinal analyses were performed in an observational study conducted 940 male Veterans OSA. Data for characteristics, polysomnography (5 ± 2 years) use obtained from records. Logistic regression was used associations between features, including regular use.A...
Periodic limb movements during sleep (PLMS) are associated with immediate increases in blood pressure. Both PLMS and hypertension have different distributions across racial/ethnic groups. We sought to determine whether is among various A total of 1740 men women underwent measurement pressure polysomnography quantification PLMS. Hypertension was defined as systolic (SBP) ≥140, diastolic BP ≥90, or taking antihypertensive medication. For those antihypertensives, an estimated pretreatment SBP...
To determine the frequency of suicidal ideation and assess suicide risk in cluster headache (CH) patients compared to matched controls without CH this observational case-control study.CH is characterized by recurrent intolerable attacks unilateral retro-orbital pain, which can cause disability, depression, desperation. has been linked since its early descriptions B.T. Horton; however, there relatively little empiric data showing association between suicidality CH, especially context other...
Obstructive sleep apnea is a well-established risk factor for cardiovascular disease (CVD). Recent studies have also linked periodic limb movements during to CVD. We aimed determine whether and obstructive are independent or synergistic factors CVD events death.
<strong>Background:</strong> In the past few decades, much has been learned about pathophysiology of restless legs syndrome (RLS). Investigators have studied neuropathology, imaging, electrophysiology, and genetics RLS, identifying brain regions biological systems affected in RLS. This manuscript will review RLS literature, examining state through consideration neuroanatomy, then biological, organ, genetic systems. <strong>Methods:</strong> Pubmed (1966 to April 2016) was searched for term...
<b><i>Background:</i></b> Wake-up stroke (WUS) accounts for a quarter of all ischemic strokes. Its conspicuous occurrence during sleep suggests that WUS may be associated with obstructive apnea (OSA). We investigated the potential association among WUS, OSA, and measures sympathetic hyperactivity. <b><i>Methods:</i></b> This is cross-sectional analysis data from Sleep Apnea in Transient Ischemic Attack Stroke (SLEEP TIGHT) study. patients were...
Background Mechanisms underlying blood pressure (BP) changes in obstructive sleep apnoea (OSA) are incompletely understood. We assessed the associations between BP and selected polysomnography (PSG) traits: depth, airflow limitation measurements OSA-specific hypoxic burden. Methods This cross-sectional analysis included 2055 participants from Multi-Ethnic Study of Atherosclerosis who underwent PSG 2010–2013. Sleep depth was using ‘OR product’, a continuous measure arousability. Airflow by...
Background and Purpose— Many health effects of sleep apnea (SA) may be mediated through accelerated atherosclerosis. We examined the associations snoring several measurements SA with subclinical carotid atherosclerosis in a large multiethnic population sample. Methods— This analysis included 1615 participants (mean age, 68 years) from examination 5 (2010–2013) MESA study (Multi-Ethnic Study Atherosclerosis). Sleep measures including (apnea-hypopnea index [4%], ≥15 events/hour) were derived...