A5061287441- Sleep and Wakefulness Research
- Sleep and related disorders
- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- EEG and Brain-Computer Interfaces
- Memory and Neural Mechanisms
- Heart Rate Variability and Autonomic Control
- Circadian rhythm and melatonin
- Dementia and Cognitive Impairment Research
- Poisoning and overdose treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Pain Management
- Cardiac electrophysiology and arrhythmias
- Health, Environment, Cognitive Aging
- Hematological disorders and diagnostics
- Cardiovascular and Diving-Related Complications
- Health and Well-being Studies
- Child and Animal Learning Development
- Nausea and vomiting management
- Conducting polymers and applications
- Pediatric health and respiratory diseases
- Sleep and Work-Related Fatigue
- Neurosurgical Procedures and Complications
- Diet and metabolism studies
- Multiple Sclerosis Research Studies
Beth Israel Deaconess Hospital
2014-2025
Harvard University
2014-2024
Brigham and Women's Hospital
2006-2024
Beth Israel Deaconess Medical Center
2009-2024
Circadian (United States)
2018-2024
University of California System
2022
University of California, San Diego
2022
Hadassah Medical Center
2021
GTx (United States)
2020
In-Q-Tel
2020
A growing literature supports a role for sleep after training in long-term memory consolidation and enhancement. Consequently, interrupted should result cognitive deficits. Recent evidence from an animal study indeed showed that optimal during requires certain amount of uninterrupted sleep. Sleep continuity is disrupted various medical disorders. We compared performance on motor sequence learning task (MST) relatively young subjects with obstructive apnea (n = 16; apnea-hypopnea index...
Studies of neural activity in animals and humans suggest that experiences are "replayed" cortical hippocampal networks during NREM sleep. Here, we examine whether memory reactivation sleeping might also be evident within reports concomitant subjective experience (i.e., dreaming). Participants were trained on an engaging visuomotor learning task across a period one or more days, sleep onset mentation was collected at variable intervals using the "Nightcap" home-monitoring device. Verbal...
The ability to categorize objects and events in the world around us is a fundamental critical aspect of human learning. We trained healthy adults on probabilistic category-learning task two different training modes. aim this study was see whether either form category learning (feedback or observational) undergoes subsequent enhancement during sleep. Our results suggest that after training, good night sleep can lead improved performance following day such tasks.
Obstructive sleep apnea (OSA) is associated with increased risk of adverse cardiovascular events. Because cardiopulmonary exercise testing (CPET) aids in prognostic assessment heart disease, there rising interest its utility for stratification patients OSA. However, the relationship between OSA and capacity unclear. This study was conducted to test hypothesis that impaired capacity.Fifteen subjects moderate-to-severe (apnea-hypopnea index [AHI] ≥15 events/h) 19 controls mild or no (AHI <15...
Aging markedly increases the risk of both Alzheimer's disease (AD) and obstructive sleep apnea (OSA). Memory deficits, an early indicator AD, can be reduced in middle-aged OSA sufferers through treatment, with positive-airway pressure being first line treatment standard. Here, we utilize natural variation severity older-aged cohort to investigate whether hypoxia or quality predict sleep-dependent memory consolidation (SDMC). Participants aged 65-85 years not currently receiving were...
Background Increasing age is associated with a decline in cognition and motor skills, while at the same time exacerbating one's risk of developing obstructive sleep apnea (OSA). OSA-related cognitive deficits are highly prevalent can affect various memory systems including overnight consolidation on sequence task. Thus, aim our study was to examine effect aging sleep-dependent patients without OSA. Methods We studied 44 (19–68 years) who had been referred by physician for baseline...
Background Mechanisms underlying blood pressure (BP) changes in obstructive sleep apnoea (OSA) are incompletely understood. We assessed the associations between BP and selected polysomnography (PSG) traits: depth, airflow limitation measurements OSA-specific hypoxic burden. Methods This cross-sectional analysis included 2055 participants from Multi-Ethnic Study of Atherosclerosis who underwent PSG 2010–2013. Sleep depth was using ‘OR product’, a continuous measure arousability. Airflow by...
There are conflicting findings regarding the link between sleep apnea and cognitive dysfunction.Investigate associations indicators of sleep-disordered breathing (SDB) function in Multi-Ethnic Study Atherosclerosis assess effect modification by apolipoprotein ε-4 (APOE-ε4) allele.A diverse population (N = 1,752) underwent type 2 in-home polysomnography, which included measurement percentage time less than 90% oxyhemoglobin saturation (%Sat < 90%) apnea-hypopnea index (AHI). Epworth...
Summary The pathophysiological processes of Alzheimer's dementia predate its clinical manifestation. Sleep disturbances can accelerate the aging process and are common features dementia. This study examined whether quantitative sleep electroencephalogram changes development mild cognitive impairment and/or incident We collected data from a nested case‐control sample women (mean age 83 years) Cognition Study, an ancillary to longitudinal Study Osteoporotic Fractures, who were characterized as...
Summary Sleep architecture encodes relevant information on the structure of sleep and has been used to assess hyperarousal in insomnia. This study investigated whether polysomnography‐derived displays signs individuals with insomnia compared without Data from Phase 3 clinical trials, private clinics a cohort were analysed. A comprehensive set features previously associated retrospectively analysed focusing sleep–wake transition probabilities, electroencephalographic spectra spindles,...
The clinical importance of obstructive sleep apnea, which can be prevalent during rapid eye movement (REM) sleep, is unclear. current study examines the effect REM-related apnea on motor memory consolidation as well mood states.We compared performance sequence task (MST), psychomotor vigilance test (PVT), Functional Outcomes Sleep Questionnaire, and Profile Mood State (POMS) survey between 3 groups: healthy controls (n = 18), REM-exclusive OSA 17), patients with respiratory events throughout...
Abstract Study Objectives Post hoc analysis to evaluate the effect of daridorexant on sleep architecture in people with insomnia, focusing features associated hyperarousal. Methods We studied adults chronic insomnia disorder from two randomized phase 3 clinical studies (Clinicaltrials.gov: NCT03545191 and NCT03575104) investigating months treatment (placebo, 25 mg, 50 mg). analyzed sleep–wake transition probabilities, EEG spectra, spindle properties including density, dispersion, slow...
Rationale: A growing body of evidence suggests that sleep is critical for the adaptive processing and consolidation emotional information into long-term memory. Previous research has indicated components scenes particularly benefit from in healthy groups yet sleep-dependent memory processes remain unexplored clinical cohorts, including those with obstructive apnea (OSA). This line important as it will add to understanding how disrupted OSA contributes both impaired cognition emotion...
Abstract INTRODUCTION Sleep is crucial for memory consolidation and the clearance of toxic proteins associated with Alzheimer's disease (AD). We examined association between sleep characteristics imaging biomarkers early amyloid beta (Aβ) tau pathology as well neurodegeneration in brain regions known to be affected incipient stages AD. METHODS Thirty‐nine cognitively unimpaired (CU) participants Harvard Aging Brain Study underwent at‐home polysomnography positron emission tomography...
Studies linking MRI findings in MS patients with obstructive sleep apnea severity are limited.We conducted a retrospective study to assess abnormalities associated (OSA) multiple sclerosis (MS).We performed chart review of 65 who had undergone polysomnography (PSG) for fatigue as well brain MRI. We measured the number lesions brainstem and calculated standardized third ventricular width (sTVW) measure atrophy, subsequently correlation analyses apnea-hypopnea index (AHI) lesion location,...
Journal Article Normalized electroencephalogram power: a trait with increased risk of dementia Get access Magdy Younes, Younes Sleep Disorders Center, Misericordia Health University Manitoba, Winnipeg, Canada Corresponding author. 255 Wellington Crescent, unit 1105, R3M 3V4, Canada. Email: mkyounes@shaw.ca. Search for other works by this author on: Oxford Academic Google Scholar Susan Redline, Redline Departments Medicine, Neurology and Psychiatry, Brigham Women's Hospital, Boston MA, USA...
We and others have reported that quantitative EEG indices may serve as biomarkers for predicting onset of dementia or cognitive decline. tested whether newly derived predict mild impairment (MCI), dementia, clinically significant decline in older women. 294 women (82.3 ± 3.2 years) without completed overnight polysomnography 2002–2004, returned testing 5 years later. Women were classified at follow-up normal, MCI based on neuropsychological evaluation. Baseline was analyzed alpha-intrusion...