A5033579092- Obstructive Sleep Apnea Research
- Bat Biology and Ecology Studies
- Sleep and Wakefulness Research
- Animal Vocal Communication and Behavior
- Marine animal studies overview
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Cardiovascular and exercise physiology
- Respiratory Support and Mechanisms
- Animal Behavior and Reproduction
- Neurobiology of Language and Bilingualism
- Marine and fisheries research
- Dietary Effects on Health
- Bariatric Surgery and Outcomes
- Circadian rhythm and melatonin
- Advanced Statistical Modeling Techniques
- Physiological and biochemical adaptations
- Guidance and Control Systems
- Music Technology and Sound Studies
- Fish Ecology and Management Studies
- Human-Animal Interaction Studies
- Animal Ecology and Behavior Studies
- Cardiovascular Disease and Adiposity
- Neurobiology and Insect Physiology Research
- Nutritional Studies and Diet
University of California, San Diego
2023-2025
University of Oxford
2017-2025
University of California System
2024
UC San Diego Health System
2024
Tel Aviv University
2021
Science Oxford
2019
Growing evidence suggests that brain activity during sleep, as well sleep regulation, are tightly linked with synaptic function and network excitability at the local global levels. We previously reported a mutation in synaptobrevin 2 (Vamp2) restless (rlss) mice results marked increase of wakefulness suppression particular REM (REMS), increased consolidation wakefulness. In this study, using finer-scale vivo electrophysiology recordings, we report spontaneous cortical rlss NREM (NREMS) is...
Aging markedly increases the risk of both Alzheimer's disease (AD) and obstructive sleep apnea (OSA). Memory deficits, an early indicator AD, can be reduced in middle-aged OSA sufferers through treatment, with positive-airway pressure being first line treatment standard. Here, we utilize natural variation severity older-aged cohort to investigate whether hypoxia or quality predict sleep-dependent memory consolidation (SDMC). Participants aged 65-85 years not currently receiving were...
Bats, quoted as sleeping for up to 20 h a day, are an often used example of extreme sleep duration amongst mammals. Given that has historically been one the primary metrics featured in comparative studies sleep, it is important species specific durations well founded. Here, we re-examined evidence characterization bats sleepers and discuss whether provides useful representation behavior Chiroptera. Although there wealth activity data suggest diurnal cycle dominated by rest, estimates time...
Abstract Sleep is associated with many costs, but also important to survival, a lack of sleep impairing cognitive function and increasing mortality. Sleeping in groups could alleviate sleep‐associated or introduce new costs if social sleeping disrupts sleep. Working the Jamaican fruit bat ( Artibeus jamaicensis) , we aimed to: (1) describe architecture, (2) assess how affects sleep, (3) quantify total time identify rapid eye movement (REM) using behavioral indicators that complement...
Abstract Collective behaviours are widely assumed to confuse predators, but empirical support for a confusion effect is often lacking, and its importance must depend on the predator’s targeting mechanism. Here we show that Swainson’s Hawks Buteo swainsoni other raptors attacking swarming Mexican Free-tailed Bats Tadarida brasiliensis steer by turning towards fixed point in space within swarm, rather than using closed-loop pursuit of any one individual. Any prey with which predator collision...
Abstract Vocalisations are increasingly being recognised as an important aspect of normal rodent behaviour yet little is known how they interact with other spontaneous behaviours such sleep and torpor, particularly in a social setting. We obtained chronic recordings the vocal adult male female Djungarian hamsters ( Phodopus sungorus ) housed under short photoperiod (8 h light, 16 dark, square wave transitions), different contexts. The animals were kept isolation or same-sex sibling pairs,...
Word finding difficulties are often seen in children with language difficulties. Their problem is readily observed and has led to investigations of its nature encouraged attempts at intervention. Semantic errors their naming suggest that knowledge items poorly developed therapies strengthen it may be effective. Twelve between 7 11 years age were offered 3 hours semantic therapy two 15-minute sessions per week for 6 weeks. The had severe complex speech, communication needs all the bottom 5%...
Abstract Background During non-rapid eye movement sleep (NREM), alternating periods of synchronised high (ON period) and low (OFF neuronal activity are associated with amplitude delta band (0.5–4 Hz) oscillations in neocortical electrophysiological signals termed slow waves. As this oscillation is dependent crucially on hyperpolarisation cortical cells, there an interest understanding how silencing during OFF leads to the generation waves whether relationship changes between layers. A...
Abstract Introduction Obstructive sleep apnea (OSA) is common in older adults and has recently been implicated the pathogenesis of Alzheimer’s disease (AD). Sleep disruption a possible reversible cause memory impairment. Furthermore, quality determined to be one most important variables affecting overnight consolidation. As part larger study, data are presented evaluating correlations between markers severity sleep-dependent Methods Seventy-one ages 65-83 (M=70, SD=4.1) with normal cognition...
Abstract Introduction Obstructive sleep apnea (OSA) is associated with major neurocognitive sequalae including impaired memory. OSA patients are deficient in NREM spindles (11 Hz to 16 electroencephalography (EEG) sigma oscillations) which have been shown promote This finding a result of less time spent deeper states most occur but also reduction spindle density, particularly during the later portion night. We tested hypothesis that density deficiencies driven by restriction breathing...
ABSTRACT Growing evidence suggests that brain activity during sleep, as well sleep regulation, are tightly linked with synaptic function and network excitability at the local global levels. We previously reported a mutation in synaptobrevin 2 ( Vamp2 ) restless rlss mice results marked increase of wakefulness suppression particular REM (REMS) increased consolidation wakefulness. In current study, using finer-scale vivo electrophysiology recordings, we report spontaneous cortical NREM (NREMS)...
Chinstrap penguins fall asleep thousands of times per day in the wild.
Brazilian free-tailed bats form large maternal colonies numbering in the millions across American Southwest. Each night, emerge from their roost to travel foraging locations. During this emergence, individuals fly together a dense, linear stream and exhibit collective group behavior. Upon morning return roost, flight behavior of change unpredictable paths, with little no apparent behavior, creating swarm. To understand different sensory challenges each these scenarios pose bats, we recorded...
Abstract During non-rapid eye movement sleep (NREM), synchronised neuronal activity is reflected in a specific neural oscillation observed neocortical electrophysiological signals: low frequency component characterised by depth-positive/surface-negative potentials known as slow waves, corresponding to alternating periods of high (ON period) and (OFF spiking activity. Often overlooked favour there an interest understanding how silencing during OFF leads the generation waves whether this...
Bats are quoted as sleeping for up to 20 hours a day, an example of extreme sleep duration amongst mammals. Given that is one the primary metrics featured in comparative studies sleep, it important determinations species-specific well founded. Here, we summarise evidence characterisation bats sleepers and discuss whether provides useful representation behaviour Chiroptera. Although there wealth activity data suggest diurnal cycle dominated by rest, citable they spend vast majority this time...