A5076619189- Sleep and Wakefulness Research
- Sleep and related disorders
- Neural dynamics and brain function
- Circadian rhythm and melatonin
- EEG and Brain-Computer Interfaces
- Neuroscience and Neuropharmacology Research
- Transcranial Magnetic Stimulation Studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and Mental Health
- Influenza Virus Research Studies
- COVID-19 Clinical Research Studies
- Functional Brain Connectivity Studies
- Olfactory and Sensory Function Studies
- Infection Control and Ventilation
- Neuroinflammation and Neurodegeneration Mechanisms
- SARS-CoV-2 detection and testing
- Viral Infections and Vectors
- Virology and Viral Diseases
- Scientific Computing and Data Management
- Neuroscience and Neural Engineering
- Vestibular and auditory disorders
- Long-Term Effects of COVID-19
- Bat Biology and Ecology Studies
- Web Data Mining and Analysis
- Research Data Management Practices
University of Bern
2022-2025
University of Oxford
2019-2025
University Hospital of Bern
2022-2024
Wellcome Centre for Integrative Neuroimaging
2024
Parkside Hospital
2024
Massachusetts Institute of Technology
2023
Neuroscience Institute
2022-2023
Kavli Energy NanoScience Institute
2022-2023
Institute of Cognitive and Brain Sciences
2023
Science Oxford
2021
Designer receptors exclusively activated by designer drugs (DREADDs) are chemogenetic tools for remote control of targeted cell populations using chemical actuators that bind to modified receptors. Despite the popularity DREADDs in neuroscience and sleep research, potential effects DREADD actuator clozapine-N-oxide (CNO) on have never been systematically tested. Here, we show intraperitoneal injections commonly used CNO doses (1, 5, 10 mg/kg) alter wild-type male laboratory mice. Using...
GABA-ergic neurotransmission plays a key role in sleep regulatory mechanisms and brain oscillations during sleep. Benzodiazepines such as diazepam are known to induce sedation promote sleep, however, EEG spectral power slow frequencies is typically reduced after the administration of benzodiazepines or similar compounds. waves arise from synchronous alternation between periods cortical network activity (ON) silence (OFF), represent sensitive marker preceding sleep-wake history. Yet it...
Electrophysiological recordings from freely behaving animals are a widespread and powerful mode of investigation in sleep research. These generate large amounts data that require stage annotation (polysomnography), which the is parcellated according to three vigilance states: awake, rapid eye movement (REM) sleep, non-REM (NREM) sleep. Manual current computational methods ignore intermediate states because classification features become ambiguous, even though contain important information...
Sleep disturbances are common in depression, but their neurobiological correlates poorly understood. Recent evidence suggests links between insula dysfunction and sleep dysregulation. This study aimed to explore the association of quality structural functional characteristics major depressive disorder (MDD). We included 47 patients with MDD 15 healthy controls (HC) matched for age sex. was assessed Pittsburgh Quality Index (PSQI). Patients were classified into two subgroups poor (PAT-PS,...
Here, we characterized the dynamics of sleep spindles, focusing on their damping, which estimated using a metric called oscillatory-Quality (o-Quality), derived by fitting an autoregressive model to electrophysiological signals, recorded from cortex in mice. The o-Quality spindles correlates weakly with amplitude, shows marked laminar differences and regional topography across cortical regions, reflects level synchrony within between networks, is strongly modulated sleep-wake history, degree...
Non-rapid eye movement (NREM) sleep is not uniform but characterized by brief intrusions of wake-like brain activity, known as micro-arousals or awakenings. Although are an inherent feature both human and animal sleep, knowledge about the neural correlates across cortical column sparse. We here developed algorithm for automatic detection based on EMG activity used it to explore how modulate laminar in motor cortex, this relationship affected pressure mice. Our analysis showed that were...
Growing evidence suggests that brain activity during sleep, as well sleep regulation, are tightly linked with synaptic function and network excitability at the local global levels. We previously reported a mutation in synaptobrevin 2 (Vamp2) restless (rlss) mice results marked increase of wakefulness suppression particular REM (REMS), increased consolidation wakefulness. In this study, using finer-scale vivo electrophysiology recordings, we report spontaneous cortical rlss NREM (NREMS) is...
Abstract Body temperature is an important physiological parameter in many studies of laboratory mice. Continuous assessment body has traditionally required surgical implantation a telemeter, but this invasive procedure adversely impacts animal welfare. Near-infrared thermography provides non-invasive alternative by continuously measuring the highest on outside (T skin ), reliability these recordings as proxy for continuous core ) measurements not been assessed. Here, T (30 s resolution) and...
Bidirectional communication between neurons and glial cells is crucial to establishing maintaining normal brain function. Some of these interactions are activity-dependent, yet it remains largely unexplored how acute changes in neuronal activity affect glial-to-neuron neuron-to-glial dynamics. Here, we use excitatory inhibitory designer receptors exclusively activated by drugs (DREADD) study the effects chemogenetic manipulations a subpopulation layer 5 cortical projection dentate gyrus adult (Rbp4
One of the most distinctive features mammalian cerebral cortex is its laminar structure. Of all cortical layers, layer 6b (L6b) by far least-studied, despite exhibiting direct sensitivity to orexin and having widespread connectivity, suggesting an important role in regulating oscillations brain state. We performed chronic electroencephalogram (EEG) recordings mice which a subset L6b neurons was conditionally silenced, during undisturbed conditions, after sleep deprivation (SD),...
Summary The slow oscillation is a central neuronal dynamic during sleep, and generated by alternating periods of high low activity (ON‐ OFF‐states). Mounting evidence causally links the to sleep's functions, it has recently become possible manipulate non‐invasively phase‐specifically. These developments represent promising clinical avenues, but they also highlight importance improving our understanding how ON/OFF‐states affect incoming stimuli what role play in plasticity. Most studies using...
Abstract Sleep spindles are traditionally defined as 10-15Hz thalamo-cortical oscillations typical of NREM sleep. While substantial heterogeneity in the appearance or spatio-temporal dynamics spindle events is well recognised, physiological relevance underlying fundamental property - oscillatory strength has not been studied. Here we introduce a novel metric called Quality ( o-Quality ), which derived by fitting an auto-regressive model to short segments electrophysiological signals,...
Abstract Background During non-rapid eye movement sleep (NREM), alternating periods of synchronised high (ON period) and low (OFF neuronal activity are associated with amplitude delta band (0.5–4 Hz) oscillations in neocortical electrophysiological signals termed slow waves. As this oscillation is dependent crucially on hyperpolarisation cortical cells, there an interest understanding how silencing during OFF leads to the generation waves whether relationship changes between layers. A...