A5075850223- Cardiovascular and exercise physiology
- Sleep and Wakefulness Research
- Neuroscience and Neuropharmacology Research
- Physical Activity and Health
- Neuroinflammation and Neurodegeneration Mechanisms
- Circadian rhythm and melatonin
- Child and Animal Learning Development
- Zebrafish Biomedical Research Applications
- Obesity, Physical Activity, Diet
- Anesthesia and Neurotoxicity Research
- Neurogenesis and neuroplasticity mechanisms
- Tryptophan and brain disorders
- Behavioral Health and Interventions
- Intensive Care Unit Cognitive Disorders
University of Oxford
2024
University of Iowa
2020
Accurately measuring activity and feeding is frequently important in laboratory animal research, whether for welfare-monitoring or experimental recording. Quantification commonly involves manual pellet-weighing; however, this can physically disturb animals cannot continuously assess both the amount pattern of feeding. Improved means food-intake measurement have been developed yet are often costly incompatible with cage configurations. We therefore validated SnackerTracker—a cost-effective,...
<ns3:p>Background Accurately measuring activity and feeding is important in laboratory animal research, whether for welfare-monitoring or experimental recording. Quantification commonly involves manual pellet-weighing; however, this can physically disturb animals cannot continuously assess both the amount pattern of over time. Improved means food-intake measurement have been developed but be costly incompatible with many cage configurations. Methods We...
Bidirectional communication between neurons and glial cells is crucial to establishing maintaining normal brain function. Some of these interactions are activity-dependent, yet it remains largely unexplored how acute changes in neuronal activity affect glial-to-neuron neuron-to-glial dynamics. Here, we use excitatory inhibitory designer receptors exclusively activated by drugs (DREADD) study the effects chemogenetic manipulations a subpopulation layer 5 cortical projection dentate gyrus adult (Rbp4
Objective measurement of physical activity (PA) using accelerometers has become increasingly popular across recreational and clinical applications. However, the effects multiple processing algorithms, filters, corrections on PA variability may be underappreciated.To examine how lifestyle estimates are impacted by available scoring methods.Wrist-worn (ActiGraph GT3X+) were worn 132 adults (87 F) having various levels for one week. Lifestyle was assessed four domains: daily energy expenditure...
ABSTRACT Cortical layer 6 (L6) neurons uniquely respond to orexin – a neuropeptide influencing arousal and emotion. We show that Drd1a-Cre+ in the prefrontal cortex are selectively sensitive regulate network activation vitro vivo. Chronically silencing these impairs orexin-induced reduces anxiety-like behaviour, indicating orexin-responsive L6 modulate emotional states may be substrate for anxiety regulation.
<title>Abstract</title> Communication between neurons and glial cells are crucial to establish maintain brain function. Some of these interactions activity-dependent, yet it remains unexplored how acute changes in neuronal activity affect neuron-to-glial dynamics. Here, we use excitatory inhibitory designer receptors exclusively activated by drugs (DREADD) based chemogenetic methods study the effects manipulations a subpopulation layer 5 cortical projection dentate gyrus adult...
One of the most distinctive features mammalian cerebral cortex is its laminar structure. Of all cortical layers, layer 6b (L6b) by far least-studied, despite exhibiting direct sensitivity to orexin and having widespread connectivity, suggesting an important role in regulating oscillations brain state. We performed chronic electroencephalogram (EEG) recordings mice which a subset L6b neurons was conditionally silenced, during undisturbed conditions, after sleep deprivation (SD),...
Physical activity (PA) can be objectively and conveniently measured using accelerometers. The use of wrist-worn devices has grown dramatically over the past decade, becoming preferred choice in many recreational, clinical research applications. ActiGraph is a leading company this field, wherein data from accelerometers analyzed their ActiLife software. However, effects multiple algorithms, filters corrections on PA outcomes are not always clear. PURPOSE: To examine how lifestyle estimates...