A5042177606- Neurological disorders and treatments
- Sleep and Wakefulness Research
- Circadian rhythm and melatonin
- Neurobiology and Insect Physiology Research
- Digital Mental Health Interventions
- Epilepsy research and treatment
- EEG and Brain-Computer Interfaces
- Olfactory and Sensory Function Studies
- Neural dynamics and brain function
- Schizophrenia research and treatment
- Mental Health Research Topics
- Autoimmune Neurological Disorders and Treatments
- Functional Brain Connectivity Studies
- Genetic Neurodegenerative Diseases
- Advanced Neuroimaging Techniques and Applications
- Sleep and related disorders
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Neuroscience and Neuropharmacology Research
- Mental Health and Psychiatry
- Tryptophan and brain disorders
- Visual perception and processing mechanisms
- Photoreceptor and optogenetics research
- History of Medical Practice
- Medical Education and Admissions
- Neuroscience and Neural Engineering
Beth Israel Deaconess Medical Center
2023-2025
Harvard University
2023-2024
Dartmouth College
2020-2023
Hadassah Medical Center
2023
Takeda (France)
2023
University of Oxford
2014-2020
Wellcome Centre for Integrative Neuroimaging
2019
Dalhousie University
2012-2015
Designer receptors exclusively activated by designer drugs (DREADDs) are chemogenetic tools for remote control of targeted cell populations using chemical actuators that bind to modified receptors. Despite the popularity DREADDs in neuroscience and sleep research, potential effects DREADD actuator clozapine-N-oxide (CNO) on have never been systematically tested. Here, we show intraperitoneal injections commonly used CNO doses (1, 5, 10 mg/kg) alter wild-type male laboratory mice. Using...
With a rapidly expanding gap between the need for and availability of mental health care, artificial intelligence (AI) presents promising, scalable solution to assessment treatment. Given novelty inscrutable nature such systems, exploratory measures aimed at understanding domain knowledge potential biases systems are necessary ongoing translational development future deployment in high-stakes healthcare settings.We investigated demographic bias generative, AI model using contrived clinical...
Abstract Major Depressive Disorder (MDD) presents considerable challenges to diagnosis and management due symptom variability across time. Only recent work has highlighted the clinical implications for interrogating depression variability. Thus, present investigates how sociodemographic, comorbidity, movement, sleep data is associated with long-term Participant information included ( N = 939) baseline sociodemographic comorbidity data, longitudinal, passively collected wearable Patient...
BACKGROUND: The expansion of neuromodulation and its indications has resulted in hundreds thousands patients with implanted devices worldwide. Because all require programming, this growth created a heavy burden on centers patients. Remote point-of-care programming may provide real-time access to expertise their communities. OBJECTIVE: To test the feasibility remotely device using remote-presence robot determine ability an expert programmer telementor nonexpert device. METHODS: A (RP-7) was...
This cross-sectional study uses 2007-2012 data from the Association of American Medical Colleges' Matriculating Student Questionnaire to evaluate student factors and academic outcomes associated with taking a leave absence medical school.
ABSTRACT A principal characteristic of the mammalian visual system is its high capacity for plasticity in early postnatal development during a time commonly referred to as critical period. The progressive diminution with age linked emergence collection molecules called molecular brakes that reduce and stabilize neural circuits modified by earlier experiences. Manipulation braking either pharmacologically or though experiential alteration enhances promotes recovery from impairment. stability...
The neurochemical mechanisms that contribute to synaesthesia are poorly understood, but multiple models implicate serotonin and GABA in the development of this condition. Here we used psychophysical tasks test predictions synaesthetes would display behavioral performance consistent with reduced elevated primary visual cortex. Controls completed orientation-specific surround suppression (OSSS) tilt-after effect (TAE) tasks, previously shown relate levels, respectively. did not differ...
Despite the frequent diagnostic delays of rare neurologic diseases (RND), it remains difficult to study RNDs and their comorbidities due rarity hence statistical underpowering. Affecting one two in a million annually, stiff person syndrome (SPS) is an RND characterized by painful muscle spasms rigidity. Leveraging underutilized electronic health records (EHR), this showcased machine-learning-based framework identify clinical features that optimally characterize diagnosis SPS.
Abstract Designer Receptors Exclusively Activated by Drugs (DREADDs) are chemogenetic tools for remote control of targeted cell populations using chemical actuators that bind to modified receptors. Despite the popularity DREADDs in neuroscience and sleep research, potential effects DREADD actuator clozapine-N-oxide (CNO) on have never been systematically tested. Here we show intraperitoneal injections commonly used CNO doses (1, 5, 10 mg/kg) alter wild-type male laboratory mice. Using...
This paper studies how to enhance the document representation for bi-encoder approach in dense retrieval. The bi-encoder, separately encoding a query and as single vector, is favored high efficiency large-scale information retrieval, compared more effective but complex architectures. To combine strength of two, multi-vector documents such ColBERT preserving all token embeddings, has been widely adopted. Our contribution reduce size representation, without compromising effectiveness,...