A5027616768- Sleep and Wakefulness Research
- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Sleep and related disorders
- Functional Brain Connectivity Studies
- Transcranial Magnetic Stimulation Studies
- Circadian rhythm and melatonin
- Neuroscience and Music Perception
- Neural and Behavioral Psychology Studies
- Olfactory and Sensory Function Studies
- Advanced Memory and Neural Computing
- Attention Deficit Hyperactivity Disorder
- Occupational Therapy Practice and Research
- Autism Spectrum Disorder Research
- Cardiovascular Syncope and Autonomic Disorders
- Restless Legs Syndrome Research
- Obstructive Sleep Apnea Research
- Schizophrenia research and treatment
- Acute Ischemic Stroke Management
- Neurogenesis and neuroplasticity mechanisms
- Neurobiology of Language and Bilingualism
- Neural Networks and Applications
- Nerve injury and regeneration
- Urban Transport and Accessibility
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
University of Geneva
2023-2024
University of Bern
2015-2023
University Hospital of Bern
2020-2023
Geneva College
2022-2023
Institut de Neurosciences Cognitives et Intégratives d’Aquitaine
2013
Centre National de la Recherche Scientifique
2013
Université de Bordeaux
2013
Designer receptors exclusively activated by designer drugs (DREADDs) are chemogenetic tools for remote control of targeted cell populations using chemical actuators that bind to modified receptors. Despite the popularity DREADDs in neuroscience and sleep research, potential effects DREADD actuator clozapine-N-oxide (CNO) on have never been systematically tested. Here, we show intraperitoneal injections commonly used CNO doses (1, 5, 10 mg/kg) alter wild-type male laboratory mice. Using...
<b><i>Introduction:</i></b> Cognitive behavioral therapy for insomnia (CBT-I) is the current first-line treatment insomnia. However, rates of nonresponse and nonremission are high effects on quality life only small to moderate, indicating a need novel developments. We propose that Acceptance Commitment Therapy (ACT) addresses core pathophysiological pathways ACT therefore has potential improve efficacy when combined with bedtime restriction, most effective component...
Approximately one-third of stroke survivors have symptoms depression. A better understanding the early risk factors implicated in this form comorbidity may contribute to development prevention strategies and improving outcomes for population. The current study uses ecological momentary assessment techniques identify behavioral depression 3 months after stroke. Thirty-six participants completed ambulatory monitoring daily life circumstances (location, social environment, activity) 5 times per...
Ageing involves significant neurophysiological changes that are both systematic while at the same time exhibiting divergent trajectories across individuals. These underlie cognitive impairments in elderly also affecting response of aged brains to interventions like transcranial direct current stimulation (tDCS). While benefits tDCS more variable elderly, older adults respond differently protocols compared young adults. The age-related influencing responsiveness remain be addressed in-depth....
Abstract Background Sleep and neurodegeneration are assumed to be locked in a bi-directional vicious cycle. Improving sleep could break this cycle help prevent neurodegeneration. We tested multi-night phase-locked acoustic stimulation (PLAS) during slow wave (SWS) as non-invasive method improve SWS, memory performance plasma amyloid levels. Methods 32 healthy older adults (agemean: 68.9) completed between-subject sham-controlled three-night intervention, preceded by sham-PLAS baseline night....
The majority of patients with mental disorders suffer from insomnia, associated adverse health outcomes. Cognitive behavioral therapy for insomnia (CBT-I) represents the first-line treatment, but is too complex severely ill and not systematically implemented in inpatient psychiatric care. This project aimed to develop a pragmatic treatment program that empowers inpatients severe take care their own sleep health.CBT-I was adapted based on implementation research involving 24 across diagnostic...
Oscillatory neural activity is considered a basis of signal transmission in brain networks. However, the causal role oscillations regulating cortico-cortical has so far not been directly demonstrated. To date, due to methodological limitations, studies on online modulatory mechanisms transcranial alternating current stimulation (tACS)-induced are confined primary motor cortex. address oscillatory modulating transmission, we have established new method using concurrent tACS, magnetic (TMS),...
Oscillatory brain activities are considered to reflect the basis of rhythmic changes in transmission efficacy across networks and assumed integrate cognitive neural processes. Transcranial alternating current stimulation (tACS) holds promise elucidate causal link between specific frequencies oscillatory activity Simultaneous electroencephalography (EEG) recording during tACS would offer an opportunity directly explore immediate neurophysiological effects tACS. However, it is not trivial...
A well orchestrated coupling hierarchy of slow waves and spindles during slow-wave sleep supports memory consolidation. In old age, the duration number events decrease. The deteriorates, predicting loss brain atrophy. Here, we investigate dynamics this physiological change in wave–spindle a frontocentral electroencephalography position large sample ( N = 340; 237 females, 103 males) spanning most human life span (age range, 15–83 years). We find that, instead changing abruptly, gradually...
Oscillatory activities of the brain and heart show a strong variation across wakefulness sleep. Separate lines research indicate that non-rapid eye movement (NREM) sleep is characterised by electroencephalographic slow oscillations (SO), spindles, phase-amplitude coupling these (SO-spindle coupling), as well an increase in high-frequency rate variability (HF-HRV), reflecting enhanced parasympathetic activity. The present study aimed to investigate further potential coordination between...
Slow-wave sleep (SWS) has been shown to promote long-term consolidation of episodic memories in hippocampo–neocortical networks. Previous research aimed modulate cortical slow-waves and spindles facilitate memory consolidation. Here, we instead hippocampal activity during slow-wave using transcranial direct current stimulation 18 healthy humans. A pair-associate task was used evaluate sleep-dependent with face–occupation stimuli. Pre- post-nap retrieval assessed as a measure performance....
Summary Slow‐wave sleep (SWS) is a fundamental physiological process, and its modulation of interest for basic science clinical applications. However, automatised protocols the suppression SWS are lacking. We describe development novel protocol automated detection (based on whole head topography frontal slow waves) (through closed‐loop modulated randomised pulsed noise), assessed feasibility, efficacy functional relevance compared to sham stimulation in 15 healthy young adults...
Oscillatory brain activities are considered to reflect the basis of rhythmic changes in transmission efficacy across networks and assumed integrate cognitive neural processes. Transcranial alternating current stimulation (tACS) holds promise elucidate causal link between specific frequencies oscillatory activity Simultaneous electroencephalography (EEG) recording during tACS would offer an opportunity directly explore immediate neurophysiological effects tACS. However, it is not trivial...
Introduction: Synchronized oscillatory brain activity is considered a basis for flexible neuronal network communication. However, the causal role of inter-regional phase relations in modulating signaling efficacy cortical networks has not been directly demonstrated humans so far. Aim: The current study addresses transcranial alternating stimulation (tACS)-induced cross-network across human networks. Methods: To this end, concurrent tACS, magnetic (TMS), and electroencephalography (EEG) were...