A5006456782- Sleep and Wakefulness Research
- Olfactory and Sensory Function Studies
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Sleep and related disorders
- EEG and Brain-Computer Interfaces
Neuroscience Institute
2022-2023
University of Freiburg
2022-2023
University of Oxford
2022-2023
Designer receptors exclusively activated by designer drugs (DREADDs) are chemogenetic tools for remote control of targeted cell populations using chemical actuators that bind to modified receptors. Despite the popularity DREADDs in neuroscience and sleep research, potential effects DREADD actuator clozapine-N-oxide (CNO) on have never been systematically tested. Here, we show intraperitoneal injections commonly used CNO doses (1, 5, 10 mg/kg) alter wild-type male laboratory mice. Using...
Abstract Designer Receptors Exclusively Activated by Drugs (DREADDs) are chemogenetic tools for remote control of targeted cell populations using chemical actuators that bind to modified receptors. Despite the popularity DREADDs in neuroscience and sleep research, potential effects DREADD actuator clozapine-N-oxide (CNO) on have never been systematically tested. Here we show intraperitoneal injections commonly used CNO doses (1, 5, 10 mg/kg) alter wild-type male laboratory mice. Using...