A5011212331- Sleep and Wakefulness Research
- Cancer Cells and Metastasis
- Neural dynamics and brain function
- Cancer, Hypoxia, and Metabolism
- EEG and Brain-Computer Interfaces
- 3D Printing in Biomedical Research
- Neuroscience of respiration and sleep
- Circadian rhythm and melatonin
- Immune cells in cancer
University of Oxford
2020-2024
Parkside Hospital
2024
Office of Science
2020-2021
Center for Cancer Research
2020-2021
National Institutes of Health
2020-2021
National Cancer Institute
2021
Science Oxford
2021
Electrophysiological recordings from freely behaving animals are a widespread and powerful mode of investigation in sleep research. These generate large amounts data that require stage annotation (polysomnography), which the is parcellated according to three vigilance states: awake, rapid eye movement (REM) sleep, non-REM (NREM) sleep. Manual current computational methods ignore intermediate states because classification features become ambiguous, even though contain important information...
Abstract The tumor microenvironment (TME) is multi-cellular, spatially heterogenous, and contains cell-generated gradients of soluble molecules. Current cell-based model systems lack this complexity or are difficult to interrogate microscopically. We present a 2D live-cell chamber that approximates the TME demonstrate breast cancer cells macrophages generate hypoxic nutrient gradients, self-organize, have varying phenotypes along leading new insights into tumorigenesis.
Abstract Electrophysiological recordings from freely behaving animals are a widespread and powerful mode of investigation in sleep research. These generate large amounts data that require stage annotation (polysomnography), which the is parcellated according to three vigilance states: awake, rapid eye movement (REM) sleep, non-REM (NREM) sleep. Manual computational methods currently ignore intermediate states because classification features become ambiguous. However, these contain important...
Abstract Torpor is a regulated reversible state of metabolic suppression used by many mammalian species to conserve energy. Although torpor has been studied extensively in terms general physiology, metabolism and neuroendocrinology, the effects hypometabolism associated hypothermia on brain activity states vigilance have received little attention. Here we performed continuous monitoring electroencephalogram (EEG), electromyogram (EMG) peripheral body temperature adult, male C57BL/6 mice over...
The tumor microenvironment (TME) is multi-cellular, spatially heterogenous, and contains cell-generated gradients of soluble molecules. Current cell-based model systems lack this complexity or are difficult to interrogate microscopically. We present a 2D live-cell chamber that approximates the TME demonstrate breast cancer cells macrophages generate hypoxic nutrient gradients, self-organize, have varying phenotypes along leading new insights into tumorigenesis.