A5062908749- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Schizophrenia research and treatment
- Transcranial Magnetic Stimulation Studies
- Electroconvulsive Therapy Studies
- Treatment of Major Depression
- Psychosomatic Disorders and Their Treatments
- Neurological disorders and treatments
- Sleep and Wakefulness Research
- Sleep and related disorders
- Attention Deficit Hyperactivity Disorder
- Substance Abuse Treatment and Outcomes
- Obsessive-Compulsive Spectrum Disorders
- Bipolar Disorder and Treatment
- Autism Spectrum Disorder Research
- Mental Health Research Topics
- Motor Control and Adaptation
- Homelessness and Social Issues
- Maternal Mental Health During Pregnancy and Postpartum
- Alcohol Consumption and Health Effects
- Memory and Neural Mechanisms
- Heart Rate Variability and Autonomic Control
- Genetics and Neurodevelopmental Disorders
- Genomic variations and chromosomal abnormalities
University of Bern
2014-2025
University Hospital of Bern
2011-2021
Cardiff University
2014-2016
University of Freiburg
2010
University Medical Center Freiburg
2009
To determine the differences in motor pathways and selected non-motor of basal ganglia Parkinson's disease (PD) patients compared to healthy controls (HCs). We analysed diffusion weighted imaging data 24 PD 26 HCs. performed deterministic tractography analysis using spherical deconvolution-based damped Richardson-Lucy algorithm subcortical volume analysis. found significantly increased fractional anisotropy (FA) patients: bilateral corticospinal tract (right; corrected p = 0.0003, left;...
BackgroundRecent genome-wide association studies have identified genetic loci that jointly make a considerable contribution to risk of developing Alzheimer's disease (AD). Because neuropathological features AD can be present several decades before onset, we investigated whether effects polygenic are detectable by neuroimaging in young adults. We hypothesized higher scores (PRSs) for would associated with reduced volume the hippocampus and other limbic paralimbic areas. further PRSs affect...
Alterations of brain structure and function have been associated with psychomotor retardation in major depressive disorder (MDD). However, the association motor behaviour white matter integrity pathways MDD is unclear. The aim present study was to first investigate structural connectivity MDD. Second, we explore relation objectively measured activity Therefore, 21 patients healthy controls matched for age, gender, education body mass index underwent diffusion tensor imaging 24 hour...
This study aimed to investigate structural and functional alterations of the reward system neurobiology craving in alcohol use disorder (AUD). We hypothesized reduced volume nucleus accumbens (NAcc), connectivity segment supero-lateral medial forebrain bundle connecting orbitofrontal cortex (OFC) with NAcc (OFC-NAcc), resting-state OFC-NAcc (FC). Furthermore, we that is related an increase FC. Thirty-nine recently abstinent patients AUD 18 healthy controls (HC) underwent (T1w-MP2RAGE,...
Structural and functional alterations of the anterior cingulate cortex (ACC) have been related to emotional, cognitive behavioral domains major depressive disorder. In this study, we investigate cortical thickness rostral caudal ACC. addition, explore white matter microstructure cingulum bundle (CB), a pathway connecting multiple segments We hypothesized reduced CB in MDD, particular melancholic subtype. expect an association between depression severity microstructure. Fifty-four patients...
Abstract Electroconvulsive therapy (ECT) is a highly effective treatment for depression. Previous studies point to ECT-induced volume increase in the hippocampi and amygdalae, cortical thickness. However, it unclear if these neuroplastic changes are associated with response. This observational study aimed address this research question by comparing neuroplasticity between patients depression receiving ECT that respond as usual (TAU-responders). Twenty ECT-patients (16 major depressive...
Objective Psychomotor abnormalities characterize both unipolar ( UP ) depression and bipolar BP depression. We aimed to assess their neurobiological correlates in terms of motor activity AL resting‐state cerebral blood flow (r CBF investigate association , healthy controls HC ). Method enrolled 42 depressed patients (22 20 19 matched for age, gender, education, income. r were objectively assessed with the use wrist actigraphy arterial spin labeling. Group differences computed. Results...
Substantial heterogeneity remains across studies investigating changes in gray matter schizophrenia. Differences methodology, heterogeneous symptom patterns and trajectories may contribute to inconsistent findings. To address this problem, we recently proposed group patients by dimensions, which map on the language, limbic motor systems. The aim of present study was investigate whether with prevalent symptoms emotional dysregulation would show structural neuronal abnormalities system.43...
Sleep disturbances are common in depression, but their neurobiological correlates poorly understood. Recent evidence suggests links between insula dysfunction and sleep dysregulation. This study aimed to explore the association of quality structural functional characteristics major depressive disorder (MDD). We included 47 patients with MDD 15 healthy controls (HC) matched for age sex. was assessed Pittsburgh Quality Index (PSQI). Patients were classified into two subgroups poor (PAT-PS,...
The medial forebrain bundle (MFB) is an important pathway of the reward system. Two branches have been described using diffusion magnetic resonance imaging (MRI)-based tractography: infero-medial MFB (imMFB) and supero-lateral (slMFB). Previous studies point to white-matter microstructural alterations slMFB in major depressive disorder (MDD) during acute episodes. To extend this finding, study investigates whether microstructure also altered MDD patients that are remission. Further, we...
Abstract Neurological soft signs (NSS) are related to grey matter and functional brain abnormalities in schizophrenia. Studies healthy subjects suggest, that NSS also linked white matter. However, the association between schizophrenia remains be elucidated. The present study investigated, if alterations patients with total sample included 42 controls 41 We used Evaluation Scale (NES), we acquired diffusion weighted magnetic resonance imaging assess on a voxel-wise subject statistic. In...
Recent evidence suggests that individual differences in physical activity (PA) may be associated with white matter microstructure and grey volume of the hippocampus. Therefore, this study investigated association between PA pathways connecting to A total 33 young, healthy adults underwent magnetic resonance imaging (MRI). High angular resolution diffusion-weighted multi-component relaxometry MRI scans (multi-component driven equilibrium pulse observation T1 T2) were acquired for each...
The purpose of this study was to evaluate a programme lesion surgery carried out on patients with treatment-resistant depression (TRD).This retrospective looking at clinical and psychometric data from 45 TRD who had undergone bilateral stereotactic anterior capsulotomy over period 15 years, the approval Mental Health Act Commission (37 unipolar eight bipolar disorder). Beck Depression Inventory (BDI) before after used as primary outcome measure. Montgomery-Asberg Rating Scale administered...
Electroconvulsive therapy (ECT) is a highly efficient treatment for depression. Previous studies repeatedly reported an ECT-induced volume increase in the hippocampi. We assume that this also affects extended hippocampal networks. This study aims to investigate structural and functional interplay between hippocampi, pathways core regions of default mode network (DMN). Twenty patients with current depressive episode receiving ECT-treatment twenty age sex matched healthy controls (HC) were...