A5054901878- Schizophrenia research and treatment
- Psychosomatic Disorders and Their Treatments
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Action Observation and Synchronization
- Neurological disorders and treatments
- Mental Health and Psychiatry
- Advanced MRI Techniques and Applications
- Neurobiology of Language and Bilingualism
- Transcranial Magnetic Stimulation Studies
- Mental Health Research Topics
- Obsessive-Compulsive Spectrum Disorders
- Bipolar Disorder and Treatment
- Autism Spectrum Disorder Research
- Hearing Impairment and Communication
- Electroconvulsive Therapy Studies
- Cerebral Palsy and Movement Disorders
- Neural and Behavioral Psychology Studies
- Fetal and Pediatric Neurological Disorders
- Hemispheric Asymmetry in Neuroscience
- Psychiatric care and mental health services
- Parkinson's Disease Mechanisms and Treatments
- MRI in cancer diagnosis
- Neuroscience and Music Perception
- Psychiatry, Mental Health, Neuroscience
University of Bern
2014-2023
University Hospital of Bern
2014-2023
Warneford Hospital
2022
University of Oxford
2022
Heidelberg University
2021
Translational Research Institute
2020
Universitäre Psychiatrische Dienste Bern
2015-2016
University Hospital
2016
Motor abnormalities are frequently observed in schizophrenia and structural alterations of the motor system have been reported. The association aberrant network function, however, has not tested. We hypothesized that abnormal functional connectivity would be related to degree schizophrenia. In 90 subjects (46 patients) we obtained resting stated magnetic resonance imaging (fMRI) for 8 minutes 40 seconds at 3T. Participants further completed a battery on scanning day. Regions interest (ROI)...
Schizophrenia patients are severely impaired in nonverbal communication, including social perception and gesture production. However, the impact of on gestural behavior remains unknown, as is contribution negative symptoms, working memory, abnormal motor behavior. Thus, study tested whether poor was related to performance, knowledge, or abnormalities. Forty-six with schizophrenia (80%), schizophreniform (15%), schizoaffective disorder (5%) 44 healthy controls matched for age, gender,...
Catatonia is a psychomotor syndrome that not only frequently occurs in the context of schizophrenia but also other conditions. The neural correlates catatonia remain unclear due to small-sized studies. We therefore compared resting-state cerebral blood flow (rCBF) and gray matter (GM) density between patients with current without healthy controls. included 42 41 was currently present 15 (scoring >2 items on Bush Francis Rating Scale screening). Patients did differ antipsychotic medication or...
Abstract Social interaction is impaired in schizophrenia, including the use of hand gestures, which linked to poor social perception and outcome. Brain imaging suggests reduced neural activity a left-lateralized frontoparietal network during gesture preparation; therefore, gesturing might be improved through facilitation left hemispheric brain areas or via disruption interhemispheric inhibition from right homolog. This study tested whether repetitive transcranial magnetic stimulation (rTMS)...
The functional outcome of schizophrenia is heterogeneous and markers the course are missing. Functional associated with social cognition negative symptoms. Gesture performance nonverbal perception critically impaired in schizophrenia. Here, we tested whether gesture or could predict ability to adequately perform relevant skills everyday function (functional capacity) after 6 months. In a naturalistic longitudinal study, 28 patients completed tests communication at baseline follow-up....
Abstract Paranoia is a frequent and highly distressing experience in psychosis. Models of paranoia suggest limbic circuit pathology. Here, we tested whether resting-state functional connectivity (rs-fc) the was altered schizophrenia patients with current paranoia. We collected MRI scans 165 subjects including 89 spectrum disorders (schizophrenia, schizoaffective disorder, brief psychotic schizophreniform disorder) 76 healthy controls. assessed using Positive And Negative Syndrome Scale...
Up to 50% of patients with schizophrenia are suffering from motor abnormalities, which may contribute decreased quality life, impaired work capacity, and a reduced life expectancy by 10-20 years. However, the effect abnormalities on social global functioning, as well as, functional capacity is not clear. We hypothesized, that presence associated poorer outcomes in schizophrenia.We collected data 5 different 156 spectrum disorders: parkinsonism, catatonia, dyskinesia, neurological soft signs...
Objective Psychomotor abnormalities characterize both unipolar ( UP ) depression and bipolar BP depression. We aimed to assess their neurobiological correlates in terms of motor activity AL resting‐state cerebral blood flow (r CBF investigate association , healthy controls HC ). Method enrolled 42 depressed patients (22 20 19 matched for age, gender, education, income. r were objectively assessed with the use wrist actigraphy arterial spin labeling. Group differences computed. Results...
Substantial heterogeneity remains across studies investigating changes in gray matter schizophrenia. Differences methodology, heterogeneous symptom patterns and trajectories may contribute to inconsistent findings. To address this problem, we recently proposed group patients by dimensions, which map on the language, limbic motor systems. The aim of present study was investigate whether with prevalent symptoms emotional dysregulation would show structural neuronal abnormalities system.43...
Schizophrenia is frequently associated with abnormal motor behavior, particularly hypokinesia. The course of the illness tends to deteriorate in first years. We aimed assess gross activity patients a episode (n = 33) and multiple episodes 115) schizophrenia spectrum disorders using wrist actigraphy. First were younger, had higher reduced negative symptom severity. Covarying for age, chlorpromazine equivalents, symptoms, still activity. This was also true after excluding schizophreniform...
During threat, interpersonal distance is deliberately increased. Personal space regulation related to amygdala function and altered in schizophrenia, but it remains unknown whether particularly associated with paranoid threat.We compared performance two tests on personal between 64 patients schizophrenia spectrum disorders 24 matched controls. Patients were stratified those neutral affect or experience of power. In the stop-distance paradigm, participants indicated minimum tolerable...
Schizophrenia is characterized by social interaction deficits contributing to poor functional outcome. Hand gesture use particularly impaired, linked frontal lobe dysfunction and grey matter deficits. The neural correlates of impaired gesturing are currently unclear. We therefore investigated aberrant brain activity during in schizophrenia. included 22 patients with schizophrenia 25 healthy control participants matched for age, gender, education level. obtained magnetic resonance imaging...
Dimensional concepts such as the Research Domain Criteria initiative have been proposed to disentangle heterogeneity of schizophrenia. One model introduced three neurobiologically informed behavioral dimensions: language, affectivity and motor behavior. To study brain-behavior associations these dimensions, we investigated whether current alterations were linked resting state perfusion in distinct brain circuits In total, 47 patients with schizophrenia spectrum disorders 44 healthy controls...