A5061087164- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Schizophrenia research and treatment
- Tryptophan and brain disorders
- Mental Health Research Topics
- Transcranial Magnetic Stimulation Studies
- Sleep and related disorders
- Neuroscience and Music Perception
- Sleep and Wakefulness Research
- Neuroscience and Neuropharmacology Research
- HIV/AIDS Research and Interventions
- Hallucinations in medical conditions
- Advanced MRI Techniques and Applications
- Neural dynamics and brain function
- Mental Health and Psychiatry
- Psychosomatic Disorders and Their Treatments
- Neurological disorders and treatments
- HIV Research and Treatment
- Neurological and metabolic disorders
- Genomic variations and chromosomal abnormalities
- Stress Responses and Cortisol
- Child Abuse and Trauma
- Diet and metabolism studies
- Genetic Associations and Epidemiology
- Restless Legs Syndrome Research
Beth Israel Deaconess Medical Center
2019-2024
Icahn School of Medicine at Mount Sinai
2017-2023
Hadassah Medical Center
2019-2021
Massachusetts Mental Health Center
2020-2021
Harvard University
2019
Social discrimination, a type of psychological stressor, is associated with poorer physical and mental health outcomes, yet we have little understanding how discrimination affects neural functions in marginalized populations. By contrast, the effects stress on are well documented, evidence significant amygdala—a region that central to psychosocial functions. Accordingly, conducted an examination relation between self-reported exposure amygdala activity diverse sample adults. Seventy-four...
Electroretinographic dysfunction is observed in psychosis, with a-wave and b-wave amplitudes potentially serving as biomarkers. Insulin resistance (IR) childhood trauma (CT) have also been associated psychosis-spectrum disorders, particularly schizophrenia. early-course psychosis (EP) lacks exploration. This case-control exploratory study aimed to understand electroretinographic EP its relationship IR CT. The involved healthy controls (n=13) individuals (n=14) included photopic scotopic...
Abstract Schizophrenia, Schizoaffective, and Bipolar disorders share behavioral phenomenological traits, intermediate phenotypes, some associated genetic loci with pleiotropic effects. Volumetric abnormalities in brain structures are among the phenotypes consistently reported these disorders. In order to examine underpinnings of structural modifications, we performed genome-wide association analyses (GWAS) on 60 quantitative MRI a sample 777 subjects (483 cases 294 controls pooled together)....
Abstract Objective: Adverse childhood experiences (ACEs) contribute to elevations in neuropsychiatric and neurocognitive symptoms HIV+ adults. Emerging data suggest that exposures threat-related deprivation-related ACEs may have differential impacts on function, with threat exposure contributing symptoms, deprivation executive dysfunction. Yet, it remains unclear how specific types of impact Hence, the current study examined whether these two dimensions adversity differentially dysfunction...
There is burgeoning evidence that, among HIV+ adults, exposure to high levels of early life stress (ELS) associated with increased cognitive impairment as well brain volume abnormalities and elevated neuropsychiatric symptoms. Currently, we have a limited understanding the degree which difficulties observed in High-ELS samples reflect underlying neural rather than increases Here, utilized behavioral marker function, reaction time intra-individual variability (RT-IIV), sensitive both...
Abstract Importance Transcranial electrical stimulation (tES) may improve psychosis symptoms, but few investigations have targeted brain regions causally linked to symptoms. We implemented a novel montage targeting the extrastriate visual cortex (eVC) previously identified by lesion network mapping in manifestation of hallucinations. Objective To determine if guided HD-tES eVC is safe and efficacious reducing symptoms related psychosis. Design, Setting, Participants Single-center,...
Addressing comorbidities contributing to cognitive impairment in people living with HIV (PLWH) remains imperative. Prior studies utilizing reaction time intra-individual variability (RT-IIV), a robust behavioral marker of dysfunction, demonstrate increased adults who have high early life stress (ELS) exposure relative those low-ELS exposure. Yet, it is unknown whether RT-IIV elevations are due high-ELS alone or both HIV-status and high-ELS. In the current study, we explore potential additive...