A5052626034- Functional Brain Connectivity Studies
- Schizophrenia research and treatment
- Psychosomatic Disorders and Their Treatments
- Obsessive-Compulsive Spectrum Disorders
- Advanced MRI Techniques and Applications
- Transcranial Magnetic Stimulation Studies
- Advanced Neuroimaging Techniques and Applications
- Neurological disorders and treatments
- Bipolar Disorder and Treatment
- Electroconvulsive Therapy Studies
- Botulinum Toxin and Related Neurological Disorders
- Spatial Neglect and Hemispheric Dysfunction
- EEG and Brain-Computer Interfaces
- Neurology and Historical Studies
- Migraine and Headache Studies
- Genetic Neurodegenerative Diseases
- Mental Health and Psychiatry
- Attention Deficit Hyperactivity Disorder
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Hemispheric Asymmetry in Neuroscience
- Mental Health Research Topics
University of Bern
2019-2025
University Hospital of Bern
2023
Importance Psychomotor slowing is a frequent symptom of psychosis, impairing gross and fine motor behavior. It associated with poor outcomes functioning, no treatment available. Objective To investigate whether 15 sessions inhibitory repetitive transcranial magnetic stimulation (rTMS) may reduce psychomotor slowing. Design, Setting, Participants This was 4-arm, double-blind, randomized, sham-controlled trial at university hospital in Switzerland. Enrollment took place from March 2019 to...
Abstract Social interaction is impaired in schizophrenia, including the use of hand gestures, which linked to poor social perception and outcome. Brain imaging suggests reduced neural activity a left-lateralized frontoparietal network during gesture preparation; therefore, gesturing might be improved through facilitation left hemispheric brain areas or via disruption interhemispheric inhibition from right homolog. This study tested whether repetitive transcranial magnetic stimulation (rTMS)...
Abstract Paranoia is a frequent and highly distressing experience in psychosis. Models of paranoia suggest limbic circuit pathology. Here, we tested whether resting-state functional connectivity (rs-fc) the was altered schizophrenia patients with current paranoia. We collected MRI scans 165 subjects including 89 spectrum disorders (schizophrenia, schizoaffective disorder, brief psychotic schizophreniform disorder) 76 healthy controls. assessed using Positive And Negative Syndrome Scale...
Up to 50% of patients with schizophrenia are suffering from motor abnormalities, which may contribute decreased quality life, impaired work capacity, and a reduced life expectancy by 10-20 years. However, the effect abnormalities on social global functioning, as well as, functional capacity is not clear. We hypothesized, that presence associated poorer outcomes in schizophrenia.We collected data 5 different 156 spectrum disorders: parkinsonism, catatonia, dyskinesia, neurological soft signs...
Abstract Background and Hypothesis Formal thought disorder (FTD) is a core symptom of psychosis, but its neural correlates remain poorly understood. This study tested whether four FTD dimensions differ in their association with brain perfusion structure. Study Design cross-sectional investigated 110 patients schizophrenia spectrum disorders using 3T magnetic resonance imaging (MRI). The Thought Language Disorder scale (TALD) was utilized, which comprises subscales: Objective Positive (OP),...
Motor abnormalities are highly prevalent among patients with schizophrenia spectrum disorders. Very likely, motor control processes, such as dexterity and grip force (GF), impaired in schizophrenia. We aimed to explore associations between various processes investigate whether specific predict the performance of fine movements GF. Our analyses included 198 applied well-established standardized rating scales assess five different abnormalities: psychomotor slowing (PS), neurological soft...
Psychomotor slowing is a frequent symptom of schizophrenia. Short-interval intracortical inhibition assessed by transcranial magnetic stimulation demonstrated inhibitory dysfunction in The deficit results from additional noise during information processing the motor system psychosis. Here, we tested whether cortical was linked to psychomotor and network alterations. In this cross-sectional study, included 60 patients with schizophrenia determined Salpêtrière Retardation Rating Scale, 23...
The neurobiology of catatonia is still poorly understood. Particularly structural MRI studies yielded conflicting results. Heterogeneity findings was suggested to stem from specifics different rating scales. This study sought test grey matter differences between patients with catatonia, without and healthy controls using the two main instruments rating. We included 98 schizophrenia spectrum disorders 42 controls. Catatonia measured Bush Francis Rating Scale Northoff Scale. According these...
Catatonia is a neuropsychiatric syndrome, with important psychomotor features, associated schizophrenia and other psychiatric disorders. The syndrome comprises multiple symptoms including abnormal motor control, behaviors, volition, autonomic regulation. assessment relies on clinical rating scales clinicians familiar the catatonia exam. However, objective instrumentation may aid detection of catatonia. We aimed to investigate relationship between movement parameters derived from actigraphy...
Abstract Objectives Psychomotor slowing (PS) occurs in up to half of schizophrenia patients and is linked poorer outcomes. As standard treatment fails improve PS, novel approaches are needed. Here, we applied the RDoC framework using 3 units analysis, ie, behavior, self-report, physiology test, whether with PS different from without controls. Methods Motor behavior was compared between 71 25 42 healthy controls (HC) 5 measures: (1) for an expert rating scale: score Salpêtrière Retardation...
Schizophrenia is a severe mental disorder, in which 50% of the patients present with motor abnormalities such as psychomotor slowing. Slow spontaneous gait has been reported schizophrenia. However, comprehensive objective instrumental assessments multiple conditions are missing. Finally, specific patterns subjects slowing still unknown. Therefore, this study aimed to objectively assess parameters at different walking schizophrenia and without Also, we hypothesised impairments correlate...
Arterial Spin Labeling is a valuable functional imaging tool for both clinical and research purposes. However, little known about the test-retest reliability of cerebral blood flow measurements over longer periods. In this study, we investigated pulsed in assessing 3 (n=28) vs 8 (n=19) weeks interscan interval 47 healthy participants. As measure reliability, calculated voxel-wise, whole-brain, regions interest intraclass correlation coefficients. The whole-brain mean resting-state showed...
Abstract Motor abnormalities, including psychomotor slowing, are prevalent in a large proportion of individuals with schizophrenia. While postural control deficits have been observed this population, the impact motor abnormalities on stability remains unclear. This study aimed to objectively evaluate patients and without slowing healthy controls. Seventy-three schizophrenia (PS; Salpêtrière Retardation Rating Scale (SRRS) ≥ 15), 25 (non-PS; SRRS < 27 controls (HC) performed four...
Measuring brain activity during functional MRI (fMRI) tasks is one of the main tools to identify biomarkers disease or neural substrates associated with specific symptoms. However, identifying correct relies on reliable measures. Recently, poor reliability was reported for task-based fMRI The present study aimed demonstrate a finger-tapping task across two sessions in healthy participants. Thirty-one right-handed participants aged 18-60 years took part 3 weeks apart which we acquired...
Abstract Background and Hypothesis Abnormal psychomotor behavior is a core schizophrenia symptom. However, assessment of motor abnormalities with expert rating scales challenging. The Positive Negative Syndrome Scale (PANSS) includes 3 items broadly related to hypokinetic behavior. Here, we tested whether sum score the PANSS mannerisms posturing (G5), retardation (G7), disturbance volition (G13) corresponds ratings, potentially qualifying as proxy-marker abnormalities. Study Design Combining...
Abstract Background Motor abnormalities frequently occur in schizophrenia along with hallucinations, delusions, and negative symptoms. Psychomotor slowing (PS) is one of these motor characterized by reduced levels spontaneous gross activity as measured actigraphy, slowed gait fine tasks. Several reports indicated that 30–50% patients are suffering from PS. Moreover, PS associated multiple disadvantages such sedentary behavior, cardiometabolic risks predicts poor treatment outcome long-term...
Abstract Background Schizophrenia patients who are suffering from psychomotor slowing (PS) present reduced levels of spontaneous motor activity, as well gait and fine dexterity. These abnormalities predict poor clinical outcomes for the patients. Recently, MRI studies have shown both aberrant functional structural connectivity in schizophrenia with PS especially basal ganglia motor/premotor cortex. Arterial spin labeling imaging (ASL) perfusion allows quantitative measurement cerebral blood...