A5088676756- Schizophrenia research and treatment
- Psychosomatic Disorders and Their Treatments
- Obsessive-Compulsive Spectrum Disorders
- Transcranial Magnetic Stimulation Studies
- Functional Brain Connectivity Studies
- Migraine and Headache Studies
- Bipolar Disorder and Treatment
- Advanced MRI Techniques and Applications
- Genetic Neurodegenerative Diseases
- Neurology and Historical Studies
- Electroconvulsive Therapy Studies
- Neurological disorders and treatments
- Advanced Neuroimaging Techniques and Applications
- Botulinum Toxin and Related Neurological Disorders
University of Bern
2022-2025
Importance Psychomotor slowing is a frequent symptom of psychosis, impairing gross and fine motor behavior. It associated with poor outcomes functioning, no treatment available. Objective To investigate whether 15 sessions inhibitory repetitive transcranial magnetic stimulation (rTMS) may reduce psychomotor slowing. Design, Setting, Participants This was 4-arm, double-blind, randomized, sham-controlled trial at university hospital in Switzerland. Enrollment took place from March 2019 to...
Motor abnormalities are highly prevalent among patients with schizophrenia spectrum disorders. Very likely, motor control processes, such as dexterity and grip force (GF), impaired in schizophrenia. We aimed to explore associations between various processes investigate whether specific predict the performance of fine movements GF. Our analyses included 198 applied well-established standardized rating scales assess five different abnormalities: psychomotor slowing (PS), neurological soft...
Psychomotor slowing is a frequent symptom of schizophrenia. Short-interval intracortical inhibition assessed by transcranial magnetic stimulation demonstrated inhibitory dysfunction in The deficit results from additional noise during information processing the motor system psychosis. Here, we tested whether cortical was linked to psychomotor and network alterations. In this cross-sectional study, included 60 patients with schizophrenia determined Salpêtrière Retardation Rating Scale, 23...
The neurobiology of catatonia is still poorly understood. Particularly structural MRI studies yielded conflicting results. Heterogeneity findings was suggested to stem from specifics different rating scales. This study sought test grey matter differences between patients with catatonia, without and healthy controls using the two main instruments rating. We included 98 schizophrenia spectrum disorders 42 controls. Catatonia measured Bush Francis Rating Scale Northoff Scale. According these...
Schizophrenia is a severe mental disorder, in which 50% of the patients present with motor abnormalities such as psychomotor slowing. Slow spontaneous gait has been reported schizophrenia. However, comprehensive objective instrumental assessments multiple conditions are missing. Finally, specific patterns subjects slowing still unknown. Therefore, this study aimed to objectively assess parameters at different walking schizophrenia and without Also, we hypothesised impairments correlate...
Arterial Spin Labeling is a valuable functional imaging tool for both clinical and research purposes. However, little known about the test-retest reliability of cerebral blood flow measurements over longer periods. In this study, we investigated pulsed in assessing 3 (n=28) vs 8 (n=19) weeks interscan interval 47 healthy participants. As measure reliability, calculated voxel-wise, whole-brain, regions interest intraclass correlation coefficients. The whole-brain mean resting-state showed...
Abstract Motor abnormalities, including psychomotor slowing, are prevalent in a large proportion of individuals with schizophrenia. While postural control deficits have been observed this population, the impact motor abnormalities on stability remains unclear. This study aimed to objectively evaluate patients and without slowing healthy controls. Seventy-three schizophrenia (PS; Salpêtrière Retardation Rating Scale (SRRS) ≥ 15), 25 (non-PS; SRRS < 27 controls (HC) performed four...
Abstract Background and Hypothesis Abnormal psychomotor behavior is a core schizophrenia symptom. However, assessment of motor abnormalities with expert rating scales challenging. The Positive Negative Syndrome Scale (PANSS) includes 3 items broadly related to hypokinetic behavior. Here, we tested whether sum score the PANSS mannerisms posturing (G5), retardation (G7), disturbance volition (G13) corresponds ratings, potentially qualifying as proxy-marker abnormalities. Study Design Combining...