A5032280444- Neural and Behavioral Psychology Studies
- Functional Brain Connectivity Studies
- Neurotransmitter Receptor Influence on Behavior
- EEG and Brain-Computer Interfaces
- Substance Abuse Treatment and Outcomes
- Neurobiology of Language and Bilingualism
- Mental Health Research Topics
- Attention Deficit Hyperactivity Disorder
- Memory and Neural Mechanisms
- Reading and Literacy Development
- Psychotherapy Techniques and Applications
- Neuroscience, Education and Cognitive Function
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Behavioral Health and Interventions
- Autism Spectrum Disorder Research
- Dementia and Cognitive Impairment Research
- Neural dynamics and brain function
- Creativity in Education and Neuroscience
- Digital Mental Health Interventions
- Psychosomatic Disorders and Their Treatments
- Psychiatric care and mental health services
- Psychology, Coaching, and Therapy
- Alcoholism and Thiamine Deficiency
- Identity, Memory, and Therapy
- Cognitive Abilities and Testing
University of Bern
2016-2025
University Hospital of Bern
2006-2017
Institute of Pharmacology
2007
University of Zurich
2007
University Psychiatric Hospital
2007
Columbia University
1989
We present a program (Ragu; Randomization Graphical User interface) for statistical analyses of multichannel event-related EEG and MEG experiments. Based on measures scalp field differences including all sensors, using powerful, assumption-free randomization statistics, the yields robust, physiologically meaningful conclusions based entire, untransformed, unbiased set measurements. Ragu accommodates up to two within-subject factors one between-subject factor with multiple levels each....
In this paper, we present a multivariate approach to analyze multi-channel event-related potential (ERP) data using randomization statistics. The MATLAB-based open source toolbox Randomization Graphical User interface (Ragu) provides, among other methods, test for topographic consistency, analysis of variance, t-mapping and microstate analyses. Up two within-subject factors one between-subject factor, each with an number levels, can be defined analyzed in Ragu. Ragu analyses include all...
This study aimed to investigate structural and functional alterations of the reward system neurobiology craving in alcohol use disorder (AUD). We hypothesized reduced volume nucleus accumbens (NAcc), connectivity segment supero-lateral medial forebrain bundle connecting orbitofrontal cortex (OFC) with NAcc (OFC-NAcc), resting-state OFC-NAcc (FC). Furthermore, we that is related an increase FC. Thirty-nine recently abstinent patients AUD 18 healthy controls (HC) underwent (T1w-MP2RAGE,...
Embarrassment is a social emotion that shares many characteristics with anxiety (SA). Most people experience embarrassment in their daily lives, but it quite overlooked research. We characterized through an interdisciplinary approach, introducing behavioral paradigm and applying machine learning approaches, including acoustic analyses. 33 participants wrote about embarrassing then, without knowing prior, had to read out loud the conductor. was then examined using two different approaches:...
Behavioral studies suggest that women and men differ in the strategic elaboration of verbally encoded information especially absence external task demand. However, measuring such covert processing requires other than behavioral data. The present study used event-related potentials to compare sexes lower higher order semantic during passive reading semantically related unrelated word pairs. Women showed same early context effect P1-N1 transition period. This finding indicates initial...
The selective serotonin reuptake blocker fluoxetine was administered to 49 patients with obsessivecompulsive disorder in a 12-week open clinical trial. A minimum adequate trial of at least 8 weeks treatment completed by 39 patients. Response rates were 62% (24/39) adequately treated and 49% (24/49) the whole sample. These uncontrolled findings suggest that is significant benefit for substantial proportion obsessive-compulsive However, controlled trials comparing placebo other active agents...
The Cognitive Model of Suicide proposes a suicide attentional bias in individuals with suicidal thoughts and behavior (STBs). Stroop Task (SST) was developed as behavioral measure to assess this bias. However, prior studies demonstrated poor psychometric properties the SST.
In Alzheimer's disease (AD) patients, episodic memory impairments are apparent, yet semantic difficulties also observed. While the pathology has been thoroughly studied, neurophysiological mechanisms of remain obscure. Semantic dementia (SD) is characterized by isolated deficits. The present study aimed to find an early marker mild AD and SD employing a priming paradigm during electroencephalogram recordings. Event-related potentials (ERP) (P1, N1) late (N400) word processing stages were...
For the first time, to our knowledge, in a clinical sample with alcohol use disorder (AUD), this study compared effects of two versions alcohol-specific inhibition training (Alc-IT) on drinking outcomes and experimental parameters assessing possible working mechanisms: stimulus devaluation inhibitory enhancement.Multi-centre, double-blind, three-arm RCT 3-, 6- 12-month follow-up comparing standard Alc-IT, improved Alc-IT an active control condition.Three specialized AUD treatment centres...
Most contemporary neuroscientific models of alcohol use disorders (AUD) incorporate an imbalance between enhanced cue reactivity, which results in a strong urge to consume, and the impaired inhibitory control that urge. While these phenomena have been frequently investigated separately, studies involving both aspects thus precisely investigating postulated are rare. In this study, inhibition was addiction-specific context individual craving levels were also examined.This study compared...
Alcohol use disorder (AUD) is characterized by both impaired inhibitory control and heightened cue reactivity, including enhanced craving drinking urges in response to alcohol-related stimuli. The interaction between these two mechanisms thought be crucial the maintenance of addiction relapse. present study used a newly developed Go/NoGo-task investigate how exposure cues affects neural processing subjects with AUD. Functional magnetic resonance imaging (fMRI) was recorded during performance...
Content and contextual memory for remote public figures events was assessed with a modified version of the Presidents Test in patients Alzheimer's disease (AD) or Parkinson's (PD). Contributions executive functioning, semantic memory, explicit anterograde to abilities were also examined. The AD group had temporally extensive deficits content not accountable by dementia severity. PD did differ from control despite impairment. These results support position that different component processes...
Abstract Childhood trauma (CT) is frequent in patients with alcohol use disorder (AUD) and may impact on adult drinking behaviour treatment outcome. This study aimed to investigate the structural correlates of CT AUD, focusing amygdala, which plays a crucial role neurobiology trauma. We hypothesized reduced amygdala volume connectivity as quantified by fractional anisotropy (FA) number streamlines those AUD history moderate severe (AUD‐CT). T1‐weighted MP2RAGE diffusion‐weighted imaging...
Alcohol use disorder (AUD) is characterized by enhanced cue-reactivity and the opposing control processes being insufficient. The ability to inhibit reactions alcohol-related cues, alcohol-specific inhibition, thus crucial AUD; trainings strengthening this might increase treatment outcome. present study investigated whether neurophysiological correlates of inhibition (I) vary with craving, (II) predict drinking outcome in AUD (III) are modulated training. A total 45 recently abstinent...