A5088376945- Dermatology and Skin Diseases
- Immune Response and Inflammation
- Pharmacological Effects of Natural Compounds
- Allergic Rhinitis and Sensitization
- Urticaria and Related Conditions
- Food Allergy and Anaphylaxis Research
- Asthma and respiratory diseases
- Drug-Induced Adverse Reactions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Phytochemistry and biological activity of medicinal plants
- Exercise and Physiological Responses
- Plant-based Medicinal Research
- Medicinal Plants and Bioactive Compounds
- Neuroinflammation and Neurodegeneration Mechanisms
- Traditional Chinese Medicine Analysis
- Metabolomics and Mass Spectrometry Studies
- Ginseng Biological Effects and Applications
- Respiratory Support and Mechanisms
- Conducting polymers and applications
- Antibiotics Pharmacokinetics and Efficacy
- Mast cells and histamine
- Immune cells in cancer
- Natural product bioactivities and synthesis
- Botanical Research and Applications
- Lipid Membrane Structure and Behavior
Taizhou University
2017-2025
Taizhou Central Hospital
2017-2025
Tianjin Agricultural University
2024
Wenzhou Medical University
2023
Liaoning University of Traditional Chinese Medicine
2015-2017
Shenyang Agricultural University
2017
Linezolid is an oxazolidinone antibacterial drug, and its therapeutic drug monitoring individualized treatment have been challenged since approval. With the in-depth clinical research of linezolid, we changed our attitude toward view treatment. On basis summarizing existing studies, based on practical experience each expert in their respective professional fields, formed this consensus. Our team specialists a multidisciplinary that includes pharmacotherapists, pharmacology specialists,...
Background: Atopic dermatitis is a common inflammatory skin disease worldwide that characterized by barrier dysfunction, itching, and reduced quality of life. Objective: The research at hand aimed to delve into the anti-atopic mechanism Herba Siegesbeckiae, traditional medicinal herb, using metabolomic approach. Methods: molecular which Siegesbeckiae acts against atopic was investigated establishing mouse model while conducting metabolomics analysis on its metabolites. Results: Interleukin...
Drowning is a preventable public health concern that burdens emergency care systems globally. This study comprehensively evaluated fatal drowning patterns across population, time, and geography from 1990 to 2021 inform effective prevention strategies.
Atopic dermatitis (AD) is a common chronic skin disease driven by T-cell-mediated immune response, with inflammation and pruritus being its main clinical manifestations. Huanglian Jiedu decoction (HLJDT), which an ancient Chinese medicine herbal formula derived from Wai-Tai-Mi-Yao, potentially effective treatment for AD. We aimed to clarify the anti-inflammatory anti-pruritus mechanisms of HLJDT in AD treatment. performed immunohistochemistry, Western blotting, reverse...
Allergic rhinitis (AR) is a global health problem that appears in all age groups and affects approximately 15–30% of people. Baicalin has been used for the treatment various allergic diseases, including AR. However, metabolic mechanisms AR baicalin against have not systematically studied. Here, ovalbumin-sensitized rats were as model, animal behaviour, histological analysis, enzyme-linked immunosorbent assay (ELISA) metabolomics to elucidate mechanism The results indicated protective effect...
Apocynum venetum leaf is commonly utilized for its beneficial effects in reducing blood pressure, inducing sedation, promoting diuresis, anti-aging, and cardioprotection, which also exhibit positive on the gut microbiota. The microbiota plays a role as an endocrine organ by producing bioactive metabolites that can directly or indirectly impact host physiology, specifically cardiovascular diseases. In this study, main chemical components of A. extract (AVLE) were identified LC-MS, orally...
Recent research indicates that injections inducing unwanted anaphylactoid reactions occur frequently in a clinical setting. In this paper, we explored trends animal models following ginsenosides injections.Our model was optimized by comparing between BN rats, SD guinea pigs and ICR mice to first intravenous exposure standard compounds including ovalbumin (OVA), tannic acid (TA), Tween 80 (T80), bovine serum albumin (BSA) Compound 48/80 (C48/80), Shengmai injection (SMI) Xuesaitong (XSTI)...
HuanglianJiedu decoction (HJD) is a classic prescription for heat-clearing away and detoxifying, which used the clinical treatment of sepsis, due to sepsis refers systemic inflammatory response induced by infection in western medicine, belongs category poison-heat syndrome traditional Chinese medicine.Previous study had elucidated effective components from HJD with high affinity lipid A, can generate release pro-inflammatory-cytokines, resulting sepsis. Now anti-sepsis activities these...
Isoimperatorin (QHS) is a phytoconstituent found in the methanolic extracts obtained from roots of Angelica dahurica, which contains anti-inflammatory, anti-bacterial, analgesic, anti-tumor, and vasodilatory activities. QHS possesses potent antagonistic activity against lipopolysaccharide (LPS)-induced inflammation; however, mechanism action remains unclear. In this study, we investigated anti-inflammatory effect explored underlying mechanisms. The was purchased Jiangsu Yongjian...
Sepsis is a systemic inflammatory response syndrome caused by infection, which has no specific drug at present. UMI-77 can significantly improve the survival rate of septic mice; detailed role and its underlying mechanisms in sepsis are not clear. Inflammation array glass chip proteomic analyses were performed to elucidate latent mechanism treatment sepsis. The results showed that 7.0 mg/kg improved 5 day mice compared LPS group (60.964 vs 9.779%) ameliorated pathological conditions....
Because of the rapid action and high bioavailability, traditional Chinese medicine injections (TCMIs) had been widely used in clinical critical field. In recent years, with increasing reports adverse reaction, more attention was paid to them, acute allergic reaction main reaction. Acute included type-I anaphylaxis anaphylactoid latter found a variety TCMIs accounted for 77% But mechanism not completely understood, standard animal model established, technical guidance formulated. Thus three...
Anaphylactoid reactions, accounting for more than 77% of all immune-mediated immediate hypersensitivity have become a serious threat to public health, but their effect mechanism is not clear and diagnostic tests are limited. Comprehensive metabolite analysis may reveal the anaphylactoid systematically provide reference future purposes.Plasma from Brown Norway rats given intravenous injection saline, compound 48/80 (2.5 mL/kg) or ovalbumin (20 in 20 s first time was used study reactions...
Nonallergic hypersensitivity reaction (NHR) accounts for more than 77% of all immune-mediated immediate reactions and has become a serious threat to public health. Here, proteomics was used study the NHR mechanism two typical substances, compound 4880 ovalbumin. Twelve different proteins were suggested as potential biomarkers examining mechanism, our results revealed that mainly encompassed 2 processes, i.e., generation effect processes. The process could be classified direct stimulation,...
Huanglian Jiedu Decoction (HJD) is used for treating sepsis in China. Active components from HJD refer to various active ingredients of HJD, while component formulation (ACF) refers the combination palmatine, berberine, baicalin, and geniposide according quantity HJD. The detailed mechanisms ACF treatment are unclear. Molecular docking, surface plasmon resonance (SPR), ELISA, RT-qPCR, Western blotting were assay possible mechanism vitro. efficacy assessed by pharmacodynamics metabolomics...
Atopic dermatitis (AD) is a common chronic relapsing skin inflammation, which severely affect the quality of life patients. Inhibiting itching and enhancing immunity to mitigate scratching are key elements in fight against AD. Huanglian Jiedu decoction (HLJDD) has multiple pharmacological effects treatment However, effective ingredients underlying molecular mechanisms have not yet been fully explored. Thus, this study integrates chemistry, biochemistry, metabolomics strategies evaluate...
Dachaihu Decoction is a classical Chinese herbal prescription that effective in harmonizing lesser yang and purging internal accumulated heat. At present, it has been widely used clinical practice, the resulting outcomes are satisfactory. However, its quality indicators action mechanism still not clear. Therefore, this paper explored efficacy markers of based on literature mining, molecular biology, network pharmacology, so as to better control ensure efficacy. The were predicted analyzed...
Niloticin is an active compound isolated from Cortex phellodendri with uncharacterized anti-inflammatory activity. We assessed the drug potential of niloticin and examined its ability to target myeloid differentiation protein 2 (MD-2) ascertain mechanism for activity.The Traditional Chinese Medicine Systems Pharmacology Database was used evaluate niloticin. Bio-layer interferometry molecular docking technologies were explore how targets MD-2, which mediates a series toll-like receptor 4...
Background Atopic dermatitis (AD) is a common but complex chronic inflammatory skin condition characterised by intense pruritus, severely impacting patients’ quality of life. At present, there no specific drug for AD. Herba Siegesbeckiae (HS) had therapeutic effect on AD, its mechanism has not been completely elucidated. Purpose We aimed to understand the HS in treatment AD this study. Materials and Methods To investigate including active components, key targets pathway analyses, systemic...