A5047126023- Neurological Disease Mechanisms and Treatments
- Mitochondrial Function and Pathology
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Cholinesterase and Neurodegenerative Diseases
- Alzheimer's disease research and treatments
- Cancer-related molecular mechanisms research
- Metabolism, Diabetes, and Cancer
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- RNA modifications and cancer
- Nitric Oxide and Endothelin Effects
- Adenosine and Purinergic Signaling
- Anesthesia and Neurotoxicity Research
- Pharmacological Effects and Toxicity Studies
- Optical Imaging and Spectroscopy Techniques
- Phosphodiesterase function and regulation
- Inflammation biomarkers and pathways
- Laser Applications in Dentistry and Medicine
- Ginseng Biological Effects and Applications
- Diet and metabolism studies
- Mathematics Education and Teaching Techniques
- Electron Spin Resonance Studies
Xiamen University
2023-2024
Guizhou Normal University
2022-2024
First Affiliated Hospital of Xiamen University
2024
Second Affiliated Hospital of Nanjing Medical University
2023-2024
Hainan Normal University
2018
Ningbo University
2015-2017
Ningbo Kangning Hospital
2017
Wenzhou Medical University
2016
Tianjin University
2013
Hebei Medical University
2008-2011
Recent evidence has suggested that peripheral inflammatory responses induced by lipopolysaccharides (LPS) play an important role in neuropsychiatric dysfunction rodents. Interleukin-1β (IL-1β), a pro-inflammatory cytokine, been proposed to be key mediator variety of behavioral LPS mice. Thus, inhibition IL-1β may have therapeutic benefit the treatment disorders. However, precise underlying mechanism knock-down repairing changes remains unclear.The mice were treated with either shRNA...
Background:VGF (nonacryonimic) and phosphatidylinositol 3-kinase (PI3K)/AKT (also known as protein kinase B, PKB)/mammalian target of rapamycin (mTOR) signaling play pivotal roles in depression. However, whether 3-kinase/AKT/mTOR signaling-mediated VGF participates rapid-acting antidepressant-like actions GLYX-13 is unclear.
MicroRNA-21 (miR-21) is up-regulated in many cancers, including colorectal cancer (CRC). Nevertheless, the function of miR-21 CRC and mechanism underlying that still unclear. After analyzing expression Sec23A cell lines, we transfected highest expressing line, SW-480, with a plasmid containing an inhibitor lowest DLD-1, mimic measured effects on proliferation, migration, invasion. We also evaluated effect knocking down its Finally, assessed xenograft tumor model mice. Tumor tissues from...
Metformin has been reported to inhibit the growth of various types cancers, including prostate cancer. Yet mode anti-cancer action metformin and underlying mechanisms remain not fully elucidated. We hypothesized that antitumorigenic effects are mediated through upregulation pigment epithelium-derived factor (PEDF) expression in cancer cells. In this report, treatment significantly inhibited proliferation colony formation cells, a dose- time-dependent manner. Meanwhile, markedly suppressed...
Bile acids (BAs) metabolism has a significant impact on the pathogenesis of Alzheimer’s disease (AD). We found that deoxycholic acid (DCA) increased in brains AD mice at an early stage. The enhanced production DCA induces up-regulation bile receptor Takeda G protein-coupled (TGR5), which is also specifically neurons mouse accumulation exogenous impairs cognitive function wild-type mice, but not TGR5 knockout mice. This suggests primary mediating these effects DCA. Furthermore, excitatory...
Peripheral inflammatory responses affect central nervous system (CNS) function, manifesting in symptoms of memory deficits, depression, and anxiety. Previous studies have revealed that neuropeptide VGF (nonacronymic) C-terminal peptide TLQP-62 rapidly reinforces brain-derived neurotrophic factor (BDNF)/tropomyosin receptor kinase B (TrkB) signaling, regulating consolidation antidepressant-like action. However, whether it is beneficial for lipopolysaccharide (LPS)-induced neuropsychiatric...
RNAs may act as competing endogenous (ceRNAs), a critical mechanism in determining gene expression regulations many cancers. However, the roles of ceRNAs thyroid carcinoma remains elusive. In this study, we have developed novel pipeline called Molecular Network-based Identification ceRNA (MNIceRNA) to identify carcinoma. MNIceRNA first constructs micro RNA (miRNA)-messenger (mRNA)long non-coding (lncRNA) networks from miRcode database and weighted correlation network analysis (WGCNA), based...
Groupitizing is a well-established strategy in numerosity perception that enhances speed and sensory precision. Building on the ATOM theory, Anobile proposed sensorimotor system, which posits strong link between number action. Previous studies using motor adaptation technology have shown high-frequency leads to underestimation of perception, while low-frequency overestimation. However, impact groupitizing, whether visual motion produces similar effects, remain unclear. In this study, we...
Aims: The lipid reference intervals (RIs) that are currently used for children in China not based on studies of the local population and normally do consider age or gender differences. This study aimed to establish age- sex-specific RIs fasting serum levels pediatric aged 0 – 15 years Nanjing, China.
Depressive symptoms usually precede the cognitive decline in Alzheimer disease (AD) and worsen clinical outcome. However, neural circuitry mediating early emotional dysfunction, especially depressive AD, remains elusive. Anterior cingulate cortex (ACC) is closely related to depression vulnerable AD. By quantitative whole-brain mapping electrophysiological recording, we found that decreased axonal calcium activity neurons of ACC glutamatergic projection from ventral hippocampal CA1 (vCA1)...
Methylglyoxal (MG) is a highly reactive dicarbonyl compound exhibiting anti-tumor activity. The effects of MG have been demonstrated in some types cancer, but its role colon cancer and the mechanisms underlying this activity remain largely unknown. We investigated human mechanism using cells animal model. Viability, proliferation, apoptosis were quantified DLD-1 SW480 by Cell Counting Kit-8, plate colony formation assay, flow cytometry, respectively. migration invasion assessed wound healing...
Background Physical literacy (PL) is an important tool to promote physical activity of individuals, and the level individuals affects their behaviors. Currently, fitness college students in China a prominent issue, assessing among may provide tools directions further precisely intervene behaviors future. This study aimed develop student questionnaire (CSPLQ) address lack currently available assessment for Chinese students. We hoped collect validity evidence this measure self-assessment...
To identify the differentially expressed genes of acute myeloid leukaemia (AML) and construct verify a survival prognosis model combined with patient information.
to investigate the effect of intrapleural PNS on rabbit pleural inflammation reaction, and determine levels of transforming growth factor β1 (TGF-β1) Vascular Endothelial Growth Factor (VEGF). Forty New Zealand white rabbits were divided into four groups. The reaction model was established by injection of tetracycline hydrochloride solution cavity. Then PNS, urokinase (UK) PBS injected the pleural cavity as experiment While replaced phosphate buffer solution (PBS) control group. effusion...
Noninvasive detection of body composition plays a significant role in the improvement life quality and reduction complications patients, near-infrared (NIR) spectroscopy, with advantages painlessness convenience, is considered as most promising tool for online noninvasive monitoring composition. However, quite different from other fields using NIR such food safety environment monitoring, demands higher precision instruments well more rigorousness measurement conditions. Therefore, new...
Surveillance ship plays an important role in spaceflight TT&C network with characteristics of integrated measurement and flexible deployment. With fields like space tracking control innovating fast, there will be much more new difficult tasks for ships. To make a better use surveillance ships, it is worthy to study how scheduling planning missions future The paper try analyze current demand practical constraints. A objective function multiple principles designed. CSP model mission established.
Abstract Depressive symptoms are prevalent and precedes cognitive decline in Alzheimer’s disease (AD), which worsen the clinical outcome severely challenge life quality of patients. However, neural circuitry mediating mood disturbance AD remains elusive. Here we report that glutamatergic projection from anterior cingulate cortex (ACC) to ventral hippocampal CA1 (vCA1) acts as substrate depressive AD. We systemically mapped axonal early stage 5xFAD mice (3 months), accompanies depressive-...
The aim of the study was to test whether cytokine profile could be used as a marker differentiate between Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) and Kawasaki disease (KD). A total 70 hospitalized children with HLH KD admitted hospital for first time from March 2017 December 2021 were enrolled in this study. Fifty-five healthy normal controls. All patients controls tested six cytokines including interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-6...
Depressive symptoms are prevalent and precedes cognitive decline in Alzheimer’s disease (AD), which worsen the clinical outcome severely challenge life quality of patients. However, neural circuitry mediating early emotional dysfunction AD remains elusive. Here we report that glutamatergic projection from anterior cingulate cortex (ACC) to ventral hippocampal CA1 (vCA1) acts as substrate depressive AD. Quantitative whole-brain mapping electrophysiological study reveal attenuated ACC-vCA1...
Objective To study the effects of rehabilitation training on synaptic ultrastructure brain cortex after cerebral ischemia.Methods Sixty rats were randomly divided into a sham operation group,a ischemia group and group.A model focal was created in groups.The given balancing,grasping,rotation walking every day.The kept normal cages,taking food moving freely.Electron microscopy used to observe density cortical synapses at days 1,7,14 21 operation.Results In there numerous terminals neuropil.The...