A5102788578- Tuberculosis Research and Epidemiology
- Neuroblastoma Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Mycobacterium research and diagnosis
- Pneumonia and Respiratory Infections
- Sinusitis and nasal conditions
- Diagnosis and treatment of tuberculosis
- Infectious Diseases and Tuberculosis
- Adrenal and Paraganglionic Tumors
- HIV, Drug Use, Sexual Risk
- Restraint-Related Deaths
- Infectious Diseases and Mycology
- Hearing, Cochlea, Tinnitus, Genetics
- Protein Degradation and Inhibitors
- Thyroid Cancer Diagnosis and Treatment
- Ear Surgery and Otitis Media
- RNA modifications and cancer
- Antibiotic Resistance in Bacteria
- Immune Response and Inflammation
- Lung Cancer Research Studies
- Microbial infections and disease research
- Signaling Pathways in Disease
- Actinomycetales infections and treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Head and Neck Anomalies
Beijing Children’s Hospital
2014-2023
Capital Medical University
2014-2023
Beihang University
2021-2022
Capital Institute of Pediatrics
2016
Peking University
2013-2014
National Institutes for Food and Drug Control
2014
Beijing Center for Disease Prevention and Control
2013
Guangxi Medical University
2013
Harvard Global Health Institute
2013
Chinese Center For Disease Control and Prevention
2013
To understand better the risk of tuberculosis transmission with increasing delay in treatment, we undertook a retrospective cohort study Shenzhen, China.All pulmonary cases Shenzhen surveillance database from 1993-2010 were included. Sputum smear positivity and presence cavity used as proxies for transmission.Among 48,441pulmonary cases, 70% presented symptoms TB, 62% sputum positive, 21% had on chest x-ray. 95.3% patients self-presented evaluation illness after median 58 days began. The...
Neuroblastoma (NB) is the most common malignant tumor originating from extracranial sympathetic nervous system in children. The molecular mechanisms underlying this disease are complex, and not completely understood. Quantitative real-time PCR (qRT-PCR) was applied to quantify expression of miR-20a-5p its target gene ATG7 clinical NB tissues. biological function SH-SY5Y cells investigated through vitro studies (Real-Time cell kinetic analyzer, colony formation assay, caspase-Glo 3/7 assay...
Pediatric tuberculosis (TB) is a serious infectious disease that affects many children worldwide and more likely to be extrapulmonary than adult TB. However, the clinical epidemiological profile, cost burden of pediatric TB (EPTB) in China remain unknown. Here, we conducted descriptive, multicenter study patients from 22 hospitals across all six regions October 2015 December 2018. Of 4,654 patients, 54.23% (2,524) had pulmonary (PTB), 17.76% (827) EPTB, 28.00% (1,303) concurrent (combined...
Abstract Aim To characterize trends in drug abuse C hina before and after the 2005 initiation of ‘ P eople's W ar on D rugs’. Design Retrospective self‐controlled study. Setting Annual, nation‐wide surveillance from 2003 to 2010 all registered users hina's N ational S urveillance ystem rug A buse ( NSSDA ). Participants total 1 184 124 were involved this study classified into three groups based dates—pre‐war group n = 230 278) 2003–04, phase I 518 651) 2005–07 II 435 195) 2008–10....
We ought to explore the acquired somatic alterations, shedding light on genetic basis of alterations in NB patients with chemotherapy. Marrow blood samples from were collected before treatment, after 2nd and 4th chemotherapy for baseline research continuous monitoring by whole exome sequencing. Plasma cell free DNA (cfDNA) was prepared research. Finger nail cells extracted as self control. The clinical data analyzed. From December 2014 February 2016, 27 cases children stage IV diagnosed....
Tuberculosis (TB) is the leading cause of death due to an infectious disease worldwide, particularly in developing countries. A series candidate genes have been suggested be associated with development TB disease. Among them, human Cytokine-inducible Src homology 2(SH2) domain protein (CISH) gene has very recently reported involved T cell activation and differentiation response Mycobacterium tuberculosis infection. Here, we studied association between CISH promoter polymorphisms pediatric...
Neuroblastoma (NB) is the most common extra-cranial solid tumor in children and frequently diagnosed cancer first year of life. Previous genome-wide association studies (GWAS) Caucasian African populations have shown that single nucleotide polymorphisms (SNPs) several genes are associated with risk developing NB, while few been performed on Chinese children. Herein, we examined between genetic candidate NB In total, 127 SNPs nine target genes, revealed by GWAS other ethnic groups four...
Papillary thyroid carcinoma (PTC) is one of the most frequent malignancies endocrine system, whose mechanisms pathogenesis, progression and prognosis are still far from being clearly elucidated. Despite an increasing body evidences highlights ribosome biogenesis regulator homolog (RRS1) as a protein in yeast plants, little known about human RRS1 function.Proliferation, cell cycle apoptosis PTC cells were assessed following knockdown expression though MTT, colony formation assay, flow...
Background In this study, we aimed to optimize the condition of propidium monoazide (PMA) treatment for direct detection Mycobacterium tuberculosis (MTB) from clinical specimens. Methods The light exposure time, dark incubation bacterial load, and PMA concentration were varied determine optimal treatment. Results Overall, maximum ΔCq value was observed in group receiving a time 20 minutes, which significantly higher than others ( P < 0.05). prolongation seemed more likely result greater...
The pathogenesis and etiology of antrochoanal polyps (ACPs) remains obscure. This study aimed to characterize the inflammatory profiles investigate effect atopy on pediatric ACPs.Thirty-three ACP patients ten control subjects were enrolled from January December 2017. severity individual nasal symptoms was scored a visual analogue scale (VAS). serum total immunoglobulin E (IgE) cytokines level measured by multiplexed luminex assay.There no significant difference in VAS scores counts cells...
Pneumomediastinum (PM) secondary to foreign body aspiration (FBA) is rare in children. Although it mainly benign, some cases may be fatal. Due the nature of this clinical entity, proper assessment and management have been poorly studied so far. Here, we characterized presentation entity provided an evaluation system for management.We retrospectively reviewed children with PM FBA, who were treated Beijing Children's Hospital from January 2010 December 2015. All patients stratified according...
Background Epidemiological characteristics of paediatric burn can help to protect children from injuries. Most the previous studies have been conducted on small scale and single centre in China. This study analysed epidemiological using a large-scale multicentre database 23 children’s hospitals China increase child protection against injuries, improve quality care reduce hospitalisation costs. Methods Excerpted information medical records 6741 cases was extracted Futang Research Center...
Papillary thyroid carcinoma (PTC) is the most common type of carcinoma, and its incidence has been on increase in recent years. However, molecular mechanism PTC unclear misdiagnosis remains a major issue. Therefore, present study aimed to investigate this mechanism, identify key prognostic biomarkers. Integrated analysis was used explore differentially expressed genes (DEGs) between healthy tissue. To functions pathways associated with DEGs, Gene Ontology, pathway protein-protein interaction...
With a primary mortality, neuroblastoma (NB) is the most common extracranial solid tumor in childhood. Amplification of MYCN (v-myc avian myelocytomatosis viral oncogene derived homolog) observed 20-30 % NB cases, feature which also characterizes highly aggressive subtype disease. However, systematic study association between single nucleotide polymorphisms (SNPs) MYCN-regulated genes and risk has not been investigated. In current study, we scanned set 16 SNPs located within known or...
Objective To determine the incidence of congenital hearing loss (HL) in newborns by rate deafness-related genetic mutations. Design Clinical study consecutive Beijing using allele-specific polymerase chain reaction-based universal array. Study sample This tested 37 573 within 3 days after birth, including nine sites four genes: GJB2 (35 del G, 176 16, 235 C, 299 AT), SLC26A4 (IVS7-2 A > 2168 G), MTRNR1 (1555 1494 C T), and GJB3 (538 T). The birth condition infants was also recorded. Results...
Abstract High‐risk neuroblastoma (HR‐NB) is an aggressive childhood cancer that responds poorly to currently available therapies and associated with only about a 50% 5‐year survival rate. MYCN amplification critical driver of these tumors, but so far there have not been any approved treatments effectively treat HR‐NB by targeting or its downstream effectors. Thus, the identification novel molecular targets therapeutic strategies children diagnosed represents urgent unmet medical need. Here,...
Abstract Background Neuroblastoma (NB) is the most common extracranial malignant solid tumor in children, which highly prone to bone marrow (BM) metastasis. BM can monitor early signs of mild disease and Existing biomarkers are insufficient for diagnosis treatment NB. Bromodomain PHD finger transcription factor (BPTF) an important subunit chromatin-remodeling complex that closely associated with tumors. Here, we evaluated whether BPTF plays role predicting NB progression, explore molecular...
Neuroblastoma (NB) is a sympathetic nervous system cancer for children, occupying approximately 15% of pediatric oncology deaths. BARD1, tumor suppressor, essential genome stability by interaction with BRCA1. Here, we performed systematic investigation the association between SNPs in
Drug resistance surveillance is crucial for control of drug-resistant tuberculosis (TB). However, limited data exists on the burden TB in children. The goal this work was to generate prevalence regarding rifampicin- (RIF-) resistant childhood northern China and test feasibility Xpert surveying pediatric drug prevalence. We enrolled 362 clinically diagnosed patients collected sputum, gastric lavage aspirate (GLA), bronchoalveolar fluid (BALF), cerebral spinal (CSF) samples. solid culture were...
Delamanid (DLM) and pretomanid (PTM) are recent additions to the anti-tuberculosis (TB) drug armamentarium, they offer more effective options for drug-resistant TB treatment. In particular, DLM is included in Group C, which recommended use longer multidrug-resistant (MDR)-TB regimens.