A5103090837- Ubiquitin and proteasome pathways
- Sinusitis and nasal conditions
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Genetics and Neurodevelopmental Disorders
- Cardiovascular Health and Risk Factors
- Natural product bioactivities and synthesis
- Microbial infections and disease research
- Air Quality and Health Impacts
- Cancer-related molecular mechanisms research
- Ion Channels and Receptors
- Glioma Diagnosis and Treatment
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Microtubule and mitosis dynamics
- Down syndrome and intellectual disability research
- Pain Mechanisms and Treatments
- Workplace Health and Well-being
- Smoking Behavior and Cessation
- Sesquiterpenes and Asteraceae Studies
- FOXO transcription factor regulation
- Dietary Effects on Health
- Insect symbiosis and bacterial influences
- Herbal Medicine Research Studies
- Connective tissue disorders research
- RNA modifications and cancer
Hebei Medical University
2009-2024
Second Hospital of Hebei Medical University
2009-2024
Gansu Agricultural University
2024
First Affiliated Hospital of Anhui Medical University
2024
Anhui Medical University
2024
ZheJiang Academy of Agricultural Sciences
2024
University of British Columbia
2018-2023
Henan University
2018-2021
Capital Medical University
2016-2020
Beijing Children’s Hospital
2019-2020
Down syndrome (DS), or trisomy 21, is one of the critical risk factors for early-onset Alzheimer's disease (AD), implicating key roles chromosome 21-encoded genes in pathogenesis AD. We previously identified a role deubiquitinase USP25, encoded on regulating microglial homeostasis AD brain; however, whether USP25 affects amyloid pathology remains unknown. Here, by crossing 5×FAD and Dp16 DS mice, we observed that 21 exacerbated brain. Moreover, bacterial artificial (BAC) transgene-mediated...
Abstract The prevalence of dual usage and the relatively low cessation rate among e-cigarette (EC) users suggest that ECs have not demonstrated significant effectiveness as a smoking tool. Furthermore, there has been substantial increase in EC recent years. Therefore, objective this study is to investigate association between use incidence respiratory symptoms chronic obstructive pulmonary disease (COPD). A total 10,326 participants aged 20 55 years, without any diseases or COPD, were...
Epidemiological evidence of the effect high-level air pollution and its interaction with meteorological factors on risk acute exacerbation chronic obstructive pulmonary disease (AECOPD) is limited. Daily data AECOPD cases, pollutants were collected from 2015 to 2018 in Shijiazhuang. A distributed lag non-linear model (DLNM) was used explore cumulative PM2.5 AECOPD. The between estimated by a generalized additive (GAM) stratification model. total 4766 patients enrolled. After controlling for...
Abstract Both Down syndrome (DS) individuals and animal models exhibit hypo‐cellularity in hippocampus neocortex indicated by enhanced neuronal death compromised neurogenesis. Ubiquitin‐specific peptidase 25 ( USP25 ), a human chromosome 21 (HSA21) gene, encodes for deubiquitinating enzyme overexpressed DS patients. Dysregulation of has been associated with Alzheimer's phenotypes DS, but its role defective neurogenesis not defined. In this study, we found that upregulation impaired cell...
microRNAs (miRNAs or miRs) play important roles in modulating the occurrence and progression of atherosclerosis acute coronary syndrome (ACS). Herein, this study aimed to investigate possible role miR-9 development atherosclerosis. Initially, differentially expressed genes associated with ACS were screened miRNAs that regulate syndecan-2 (SDC2) predicted using microarray analysis. Furthermore, biological functions SDC2 on aortic plaque area, proliferation collagen fibers, Mac-3-labeled...
The pathogenesis and etiology of antrochoanal polyps (ACPs) remains obscure. This study aimed to characterize the inflammatory profiles investigate effect atopy on pediatric ACPs.Thirty-three ACP patients ten control subjects were enrolled from January December 2017. severity individual nasal symptoms was scored a visual analogue scale (VAS). serum total immunoglobulin E (IgE) cytokines level measured by multiplexed luminex assay.There no significant difference in VAS scores counts cells...
Triple-negative breast cancer shows worse outcome compared with other subtypes of cancer. The discovery dysregulated microRNAs and their roles in the progression triple-negative provide novel strategies for treatment patients In this study, we identified significant reduction miR-133 tissues cell lines. Ectopic overexpression suppressed proliferation, colony formation, upregulated apoptosis cells. Mechanism study revealed that YES Proto-Oncogene 1 was a target miR-133. bound 3′-untranslated...
Abstract Chronic obstructive pulmonary disease (COPD) is a chronic and devastating condition characterized by poor airflow breath. Smoking other environmental factors–caused inflammations triggered excessive autophagy of normal lung epithelial cells, eventually leading to impaired functions. Previous studies showed that ghrelin exhibited beneficial effects on patients with COPD. However, the mechanisms underlying this impact remained largely unknown. In study, in vitro vivo models...
Trisomy 21, an extra copy of human chromosome 21 (HSA21), causes most Down's syndrome (DS) cases. Individuals with DS inevitably develop Alzheimer's disease (AD) neuropathological phenotypes after middle age including amyloid plaques and tau neurofibrillary tangles. Ubiquitin Specific Peptidase 25 (USP25), encoding by USP25 gene located on HSA21, is a deubiquitinating enzyme, which plays important role in both AD pathogenesis. However, the regulation remains unclear.We aimed to determine...
Abstract Background Cryoballoon ablation (CBA) and radiofrequency (RFA) are the most common procedures used to treat refractory atrial fibrillation (AF) performed through pulmonary vein isolation (PVI). Studies have shown that CBA can approximately match therapeutic effects of RFA against AF. However, few studies investigated difference between on left remodeling for paroxysmal Objective Atrial is considered pivotal occurrence development AF, therefore we sought assess influence in patients...
The pathologic features and potential predictive biomarkers for recurrence of antrochoanal polyps (ACPs) in children are not fully understood.To identify the differences between recurrent nonrecurrent group to explore clinical markers which predict ACPs children.A total 11 21 were enrolled into this retrospect study. Clinical basic information was collected before first surgery. counts vessels evaluated by hematoxylin-eosin (HE) staining, CD34 detected immunohistochemistry. Meanwhile,...
The Accepted Manuscript version of this article (published on 19 August 2020) was withdrawn 3 December 2020 due to concerns over data validity.
Abstract Background Traditional methods for detecting insect-borne bacterial pathogens are time-consuming and require specialized laboratory facilities, limiting their applicability in areas without access to such resources. Consequently, rapid efficient detection diseases have become a pressing need disease prevention control. Methods We aligned the ribosomal 16S rRNA sequences of seven species ( Staphylococcus aureus, Shigella flexneri, Aeromonas caviae, Vibrio vulnificus, Salmonella...
<title>Abstract</title> <bold>Background</bold>: Minichromosome maintenance protein 5 (MCM5) has been found to be a new oncogene in many cancers. However, its role glioma remains unclear. Therefore, we mainly plan investigate the potential mechanism of MCM5 glioma. <bold>Methods</bold>: Bioinformatics tools were employed evaluate expression and relationship with clinicopathological characteristics. GEPIA database was applied assess prognostic value glioma, functional enrichment analysis also...
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Transmembrane protein TMEM16A, which encodes calcium-activated chloride channel has been implicated in tumorigenesis. Overexpression of TMEM16A is associated with poor prognosis and low overall survival multiple cancers including lung adenocarcinoma, making it a promising biomarker therapeutic target. In this study, three structure-related sesquiterpene lactones (mecheliolide, costunolide dehydrocostus lactone) were extracted from the traditional Chinese medicine Aucklandiae Radix identified...
Objective To explore the stressor status of nurses work in cardiology department at night work.Methods 98 were investigated by questionnaires.Results The pressure sources shift descending order were:the responsibility nurse is more significant (100.00％); big workload (91.83％); professional technical and experience not enough ( 89.79％ ) ; relation with patient families tension (81.63％ mind body exhausted difficult to recovery 79.59％ ).Conclusions management should adopt targeted decompression...
Objective To survey on the home blood pressure measurement and control rate among patients with hypertension in Beijing Yuetan community. Methods A questionnaire was conducted 504 hypertensive patients, who were visiting Community Health Service Center selected by convenience-sampling method during June 2018 to January 2019. The status of measurement, awareness hypertension, factors related not regularly measuring surveyed. Results Of 93.7% (472/504) took regular medication, but...
In order to develop new oleanolic acid (OA) derivatives endowed with improved antitumor activities, for the first time, a number of hybrid compounds were reported by combining OA or 3-oxooleanolic appropriate H2S-donor moiety, coupled via suitable linker. The anti-tumor evaluation indicated that they exhibited excellent anti-cancer activities against tested cancer cell lines. Moreover, 18d 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione moiety as H2S donor and β-alanine linker, showed more...
Rhinovirus picornavirus, can not only cause the common cold, but also disease of respiratory system, other acute and chronic bronchitis infection, explore mechanisms rhinovirus, development anti-rhinovirus drugs is always research focus in field. With detecting technology recent years, especially application PCR method ,much more further study rhinovirus was done. This paper respectively on pathology, detection methods its possible mechanism were summarized. Key words: Rhinovirus; inflammation