A5101571823- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Diagnosis and treatment of tuberculosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Pneumonia and Respiratory Infections
- Infectious Diseases and Tuberculosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Vitamin D Research Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Advanced biosensing and bioanalysis techniques
- HIV, Drug Use, Sexual Risk
- Spinal Hematomas and Complications
- Neurosurgical Procedures and Complications
- Pediatric health and respiratory diseases
- Advanced Nanomaterials in Catalysis
- Air Quality and Health Impacts
- COVID-19 epidemiological studies
- Biochemical and Molecular Research
- vaccines and immunoinformatics approaches
- Advanced Drug Delivery Systems
- Autophagy in Disease and Therapy
- Syphilis Diagnosis and Treatment
- HIV/AIDS Research and Interventions
- Ideological and Political Education
- Nerve injury and regeneration
Shenzhen Nanshan Center for Chronic Disease Control
2018-2025
Traditional Chinese Medicine Hospital of Kunshan
2014-2022
Nanjing University of Chinese Medicine
2018-2022
Shanghai University of Traditional Chinese Medicine
2014-2022
Shenzhen Chronic Disease Prevention Center
2013-2021
Capital University
2021
Capital Medical University
2021
Wuhan University
2021
ShenZhen People’s Hospital
2021
Hospital Sultanah Bahiyah
2020
Abstract Whole genome sequencing (WGS) can provide insight into drug-resistance, transmission chains and the identification of outbreaks, but data analysis remains an obstacle to its routine clinical use. Although several drug-resistance prediction tools have appeared, until now no website integrates with strain genetic relationships species nontuberculous mycobacteria (NTM). We established a free, function-rich, user-friendly online platform for MTB WGS (SAM-TB, http://samtb.szmbzx.com)...
Population movement could extend multidrug-resistant tuberculosis (MDR-TB) transmission and complicate its global prevalence. We sought to identify the high-risk populations geographic sites of MDR-TB in Shenzhen, most common destination for internal migrants China.
To understand better the risk of tuberculosis transmission with increasing delay in treatment, we undertook a retrospective cohort study Shenzhen, China.All pulmonary cases Shenzhen surveillance database from 1993-2010 were included. Sputum smear positivity and presence cavity used as proxies for transmission.Among 48,441pulmonary cases, 70% presented symptoms TB, 62% sputum positive, 21% had on chest x-ray. 95.3% patients self-presented evaluation illness after median 58 days began. The...
This study aims to elucidate the transmission dynamics of tuberculosis in a Chinese city with high population mobility and identify associated risk factors. We included data from ten city-level surveillance sites Shenzhen between 2018 2023. Genomic clusters were defined as having genomic distance 12 single nucleotide polymorphisms based on whole-genome sequencing. Cross-district characterized containing patients at least two districts, indicating cross-district transmission. Risk factors for...
Background WHO recommended multidrug-resistant tuberculosis (MDR-TB) should be treated mainly under ambulatory model, but outcome of treatment MDR-TB in China was little known. Methods The clinical data 261 patients as outpatients Shenzhen, during 2010–2015 were collected and analyzed retrospectively. Results Of receiving treatment, 71.1% (186/261) achieved success (cured or completed treatment), 0.4% (1/261) died 11.5% (30/261) had failure relapse, 8.0% (21/261) lost to follow-up, 8.8%...
Pulmonary tuberculosis (PTB) is a chronic communicable disease of major public health and social concern. Although spatial-temporal analysis has been widely used to describe distribution characteristics transmission patterns, few studies have revealed the changes in small-scale clustering PTB at street level.
We analyzed the trends and predictors of multidrug-resistant (MDR) or rifampicin-resistant (RR) tuberculosis (TB) in culture-positive cases Shenzhen during 2012-2020, after implementation improved strategies (scale-up molecular drug susceptibility testing [mDST], expansion DST eligibility, generous reimbursement MDR-TB outpatient care costs).We retrospectively extracted data from TB Information System on drug-resistant pulmonary diagnosed 2012-2020 period. RR- rates new 2012-2018 2018-2020...
Tuberculosis (TB) in emerging cities is often a disease of recent immigrants, and understanding this epidemiology crucial for designing effective control prevention strategies.We conducted retrospective population-based genomic epidemiological study culture-positive pulmonary TB patients diagnosed between June 2014 November 2017 the Bao'an District Shenzhen, Chinese city with dramatic growth. After whole genome sequencing, transmission clusters were defined as strains differing by no more...
Whole-genome sequencing (WGS) has excellent potential in drug-resistance prediction. The MICs are essential indications of adding a particular antituberculosis drug dosage or changing the entire treatment regimen.
Tuberculosis (TB) heteroresistance, in which only a fraction of the bacteria TB patient contains drug-resistant mutations, has been rising concern. However, its origins and prevalence remain elusive. Here, whole-genome sequencing was performed on 83 serial isolates from 31 MDR-TB patients heteroresistance detected 21 (67.74%) patients. Heteroresistance persisted host for long periods, spanning months to years, associated with having multiple tubercular lesions. Our findings indicate that is...
Internal migrants are a challenge for TB control in large Chinese cities and understanding this epidemiology is crucial designing effective prevention strategies. We conducted prospective genomic epidemiological study of culture-positive patients diagnosed between June 1, 2018 May 31, 2021 the Longhua District Shenzhen. Treatment status was obtained from local national registries all isolates were sequenced. Genomic clusters defined as strains differing by ≤12 SNPs. Risk factors clustering...
<sec> <title>SETTING</title> The proportion of bacteriologically confirmed tuberculosis (TB) in China has decreased far below the worldwide average. </sec> <title>OBJECTIVE</title> To investigate whether stepwise measures to ensure sputum quality can improve rate TB. <title>DESIGN</title> We enrolled 980 adults with suspected TB from three counties during 2017 for this multicentre randomised controlled trial. Half participants (n = 490) were randomly assigned intervention groups that...
Objective To describe the trend of tuberculosis (TB) diagnosis in migrant city Shenzhen, China, and analyze risk factors delays. Methods Demographic clinical information TB patients from 2011 to 2020 Shenzhen were extracted. A bundle measures enhance had been implemented since late 2017. We calculated proportions who underwent a patient delay (&gt;30 days syndrome onset first care-seeking) or hospital (&gt;4 care-seeking diagnosis). Multivariable logistic regression was used Results...
To explore the difference of 18F-FDG PET/CT images between symptomatic and asymptomatic pulmonary tuberculosis, as well correlation standard uptake value (SUV) symptomatic/asymptomatic tuberculosis.A study dataset 57 tuberculosis cases was retrospectively assembled analyzed. Among these cases, 30 were diagnosed having 27 tuberculosis. performed in all cases. The clinical data, CT radioactive data analyzed using statistical analysis software.All showed radioactively high uptake, with maximum...
Bacillus Calmette Guérin (BCG) has a potential anti-tumor effect on gastric cancer. However, the mechanism is still unclear. In this study, we investigated of BCG cancer cell line MGC-803 and studied cooperation lymphocyte in determining final fate cells. After treatment with BCG, viability was significantly inhibited dosage-dependent manner. Flow cytometry assay showed apoptosis rates were increased by BCG. Using western blot assay, results that cleaved-caspase-3, LC-3BII Atg-3. cocultured...
Antibody-Dependent Cellular Cytotoxicity (ADCC) is a major mechanism of protection against viral infections in vivo. Identification HIV-1-specific monoclonal antibodies (mAbs) with potent ADCC activity may help develop an effective HIV-1 vaccine.In present study, we isolated such human mAb, designated E10, from HIV-1-infected patient sample by single B cell sorting and PCR. E10 bound to gp140 trimer linear peptides derived gp41 membrane proximal external region (MPER).E10 epitope...