A5063162624- Sarcoma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Neuroblastoma Research and Treatments
- CAR-T cell therapy research
- Transgenic Plants and Applications
- Glycosylation and Glycoproteins Research
- Molecular Biology Techniques and Applications
- T-cell and B-cell Immunology
- Viral Infectious Diseases and Gene Expression in Insects
- Renal cell carcinoma treatment
- MicroRNA in disease regulation
- Protein Degradation and Inhibitors
- Cancer, Hypoxia, and Metabolism
- Barrier Structure and Function Studies
- Peptidase Inhibition and Analysis
- Wnt/β-catenin signaling in development and cancer
- Sulfur Compounds in Biology
- Cardiac tumors and thrombi
- Renal and related cancers
- Neurofibromatosis and Schwannoma Cases
- Pulmonary Hypertension Research and Treatments
- Meningioma and schwannoma management
- Glioma Diagnosis and Treatment
- Histiocytic Disorders and Treatments
- Eicosanoids and Hypertension Pharmacology
Beijing Children’s Hospital
2021-2025
Capital Medical University
2021-2025
Center for Children
2024
Tsinghua University
2021
China Agricultural University
2016-2018
A number of genetic aberrations are associated with the BCL6-correpresor gene (BCOR), including internal tandem duplications (ITDs) and fusions (BCOR::CCNB3 BCOR::MAML3), as well YWHAE::NUTM2, which found in clear cell sarcoma kidney (CCSK), BCOR alterations, primitive myxoid mesenchymal tumor infancy, high-grade neuroepithelial tumors children. Detecting these is crucial for diagnosis. ITDs can be identified by Sanger sequencing or agarose gel electrophoresis. However, usually detected...
Aerobic glycolysis is involved in the pathogenesis of pulmonary hypertension (PH). The mechanisms by which increased and how it contributes to vascular remodelling are not yet fully understood. In this study, we demonstrated that elevated lipocalin-2 (LCN2) PH significantly enhances aerobic human artery smooth muscle cells (PASMCs) up-regulating LDHA expression. Knockout Lcn2 or having heterozygous deficiency mice inhibits progression hypoxic PH. Our study reveals LCN2 stimulates expression...
Abstract High‐risk neuroblastoma (HR‐NB) is an aggressive childhood cancer that responds poorly to currently available therapies and associated with only about a 50% 5‐year survival rate. MYCN amplification critical driver of these tumors, but so far there have not been any approved treatments effectively treat HR‐NB by targeting or its downstream effectors. Thus, the identification novel molecular targets therapeutic strategies children diagnosed represents urgent unmet medical need. Here,...
Clear cell sarcoma of the kidney (CCSK) is second most common pediatric renal malignancy, characterized by BCOR internal tandem duplication (ITD), YWHAE rearrangement, BCOR-CCNB3 fusion, and lack other consistent structural alteration. We accidentally identified TP53 deletion in CCSK, which was often associated with adverse clinical outcomes. In this study, we assessed incidence as well relevance these molecules CCSK patients. ITD, fusion status were examined polymerase chain reaction,...
ABSTRACT Introduction Cardiac neoplasms are particularly rare in children, and the majority of these tumors benign. Approximately 10% cardiac malignant, including soft tissue sarcomas lymphomas. could also be metastases. Primitive EWSR1‐ negative round or spindle cell undifferentiated sarcoma harboring CIC gene translocation is a highly aggressive malignancy mainly occurring tissues. However, it has not yet been described heart. Case presentation We report that arose from right ventricle...
<title>Abstract</title> Background A number of genetic aberrations are associated with the <italic>BCL6</italic>-correpresor gene (<italic>BCOR</italic>), including internal tandem duplications (ITDs) and fusions (<italic>BCOR-CCNB3</italic> <italic>BCOR-MAML3</italic>), as well <italic>YWHAE-NUTM2</italic>, which found in clear cell sarcoma kidney (CCSK), <italic>BCOR</italic> alterations, primitive myxoid mesenchymal tumor infancy, high-grade neuroepithelial tumors children. Detecting...
Introduction: Cellular neurothekeoma is a benign tumor that mainly occurs in young children and adolescents. The aberrant expression of transcription factor E3 (TFE3) has not been reported cellular previously. Case report: We report four with immunohistochemical TFE3 protein. fluorescence situ hybridization (FISH) showed no gene rearrangement or amplification. Discussion/Conclusion: TEF3 protein may be related to translocation neurothekeoma. potential pitfall diagnosis, for several malignant...
Recently, telomerase reverse transcriptase (TERT) gene rearrangements have been identified in neuroblastoma (NB), the typical pathological type of neuroblastic tumours (NTs); however, prevalence TERT other types NT remains unknown. This study aimed to develop a practical method for detecting defects and evaluate clinical relevance as biomarker prognosis. A break-apart probe fluorescence situ hybridisation (FISH) was designed, optimised, applied assess genomic status Chinese children with NTs...
Mammals, including humans and mice, employ V(D)J recombination somatic hypermutation (SHM) to diversify their immunoglobulin (Ig) variable region repertoires, while domestic poultry, such as chickens ducks, rely heavily on gene conversion (GCV) achieve this diversification. Given the differences in arrangement of Ig loci between chickens/ducks humans/mice, we posited that structural locus might play a pivotal role driving pronounced frequency GCV poultry. To test hypothesis, engineered novel...
Mammals, including humans and mice, employ V(D)J recombination somatic hypermutation (SHM) to diversify their immunoglobulin (Ig) variable region repertoires, while domestic poultry, such as chickens ducks, rely heavily on gene conversion (GCV) achieve this diversification. Given the differences in arrangement of Ig loci between chickens/ducks humans/mice, we posited that structural locus might play a pivotal role driving pronounced frequency GCV poultry. To test hypothesis, engineered novel...