A5014138827- Animal Virus Infections Studies
- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- Gut microbiota and health
- Viral Infections and Immunology Research
- Pediatric health and respiratory diseases
- Probiotics and Fermented Foods
- Antimicrobial Peptides and Activities
- Clostridium difficile and Clostridium perfringens research
- Microscopic Colitis
- Material Properties and Applications
- SARS-CoV-2 and COVID-19 Research
- Plant Virus Research Studies
- Mast cells and histamine
- Microbial Community Ecology and Physiology
- Barrier Structure and Function Studies
- Diet and metabolism studies
- Immune cells in cancer
- MicroRNA in disease regulation
- Animal Disease Management and Epidemiology
- Organ Transplantation Techniques and Outcomes
- Protein Hydrolysis and Bioactive Peptides
- Wnt/β-catenin signaling in development and cancer
- Pediatric Urology and Nephrology Studies
- IL-33, ST2, and ILC Pathways
China Academy of Chinese Medical Sciences
2024
Tsinghua University
2018-2023
Center for Life Sciences
2018-2023
Guangzhou Medical University
2014-2019
Third Affiliated Hospital of Guangzhou Medical University
2019
China Agricultural University
2012-2018
Hong Kong Biotechnology Organization
2014
Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most important viral pathogens in swine industry. Emerging evidence indicates that host microRNAs (miRNAs) are involved host-pathogen interactions. However, whether miRNAs can target PRRSV be used to inhibit infection has not been reported. Recently, microRNA 181 (miR-181) identified as a positive regulator immune response, here we report miR-181 directly impair infection. Our results showed delivered mimics strongly...
ABSTRACT Porcine reproductive and respiratory syndrome virus (PRRSV) is a highly infectious pathogen that causes severe diseases in pigs great economic losses to the swine industry worldwide. Type I interferons (IFNs) play crucial role antiviral immunity. In present study, we demonstrated infection with pathogenic PRRSV strain JXwn06 antagonized type IFN expression induced by poly(I·C) both porcine alveolar macrophages (PAMs) blood monocyte-derived (BMo). Subsequently, showed inhibition of...
We previously showed that microRNA 181 (miR-181) can inhibit PRRSV replication by directly targeting its genomic RNA. Here, we report miR-181 downregulate the receptor CD163 in blood monocytes and porcine alveolar macrophages (PAMs) through 3' untranslated region (UTR) of mRNA. Downregulation leads to inhibition entry into PAMs subsequently suppresses infection. Our findings indicate delivery be used as antiviral therapy against
Abstract Objective Accumulating evidence from microbial studies have highlighted the modulatory roles of intestinal microbes in numerous human diseases, however, shared signatures across different diseases remain relatively unclear. Methods To consolidate existing knowledge multiple studies, we performed meta-analyses 17 disease types, covering 34 case–control datasets 16S rRNA sequencing data, to identify alterations among diseases. Furthermore, impact a species, Lactobacillus salivarius,...
As highly organized consortia of bacteria, biofilms have long been implicated in aggravating inflammation. However, our understanding regarding vivo host-biofilm interactions the complex tissue environments remains limited. Here, we show a unique pattern crypt occupation by mucus-associated during early stage colitis, which is genetically dependent on bacterial biofilm-forming capacity and restricted host epithelial α1,2-fucosylation. α1,2-Fucosylation deficiency leads to markedly augmented...
Atypical porcine reproductive and respiratory syndrome (PRRS) caused by highly pathogenic virus (HP-PRRSV) is characterized high fever mortality. However, the mechanism underlying induction still unknown. Prostaglandin E2 (PGE2), synthesized cyclooxygenase type 1/2 (COX-1/2) enzymes, essential for inducing fever. In this study, we found that PGE2, together with COX-1, was significantly elevated HP-PRRSV. We subsequently demonstrated extracellular signal-regulated kinase (ERK1/2)...
Gut microbiome dysbiosis has been known to be associated with all stages of non-alcoholic fatty liver disease (NAFLD), but questions remain about microbial profiles in progression and homogeneity across NAFLD stages. We performed a meta-analysis three publicly shotgun datasets built predictive models determine diagnostic capacity. Here, we found consistently shifts stages, which co-occurrence patterns core sets new biomarkers significantly correlated were identified. Machine learning that...
In addition to their established functions in host defense, accumulating evidence has suggested an emerging role for anti-microbial proteins (AMPs) shaping commensal microbiome. However, the of α-defensins, most abundant AMPs intestine, regulating microbial ecology remains inconclusive. Here, experiments utilizing mice deficient matrix metalloproteinase 7 (MMP7), α-defensin-activating enzyme, with rigorous littermate controls showed that α-defensin deficiency did not significantly influence...
Abstract To test the reliability of CEUS on diagnosis acute (AR) or chronic rejection (CR) after renal transplantation, patients who received transplantation in our center from January 2011 and December 2015 were retrospectively included current study. All underwent contrast-enhanced ultrasonography tests. Two regions interests chosen to carry out time-intensity curves (TICs). The main indexes include time indexes, intensity difference indexes. Separation TIC1 TIC2 was evaluated by authors....