A5101517275- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- S100 Proteins and Annexins
- RNA Research and Splicing
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- RNA regulation and disease
- Signaling Pathways in Disease
- Cardiac Fibrosis and Remodeling
- Intracerebral and Subarachnoid Hemorrhage Research
- Cell Adhesion Molecules Research
- Protist diversity and phylogeny
- Ginger and Zingiberaceae research
- Plant Disease Resistance and Genetics
- Advanced Glycation End Products research
- Mesenchymal stem cell research
- Electron Spin Resonance Studies
- Pregnancy-related medical research
- Angiogenesis and VEGF in Cancer
- Microtubule and mitosis dynamics
- Extracellular vesicles in disease
- Autophagy in Disease and Therapy
- Peroxisome Proliferator-Activated Receptors
- Cellular Mechanics and Interactions
Liaoning Cancer Hospital & Institute
2025
China Medical University
2025
Changhai Hospital
2024
Tongji Hospital
2018-2024
Henan Polytechnic University
2022-2024
Huazhong University of Science and Technology
2018-2024
Second Military Medical University
2024
People's Liberation Army 401 Hospital
2024
Third Affiliated Hospital of Southern Medical University
2023
Karolinska Institutet
2023
Baicalein, one of the major flavonoids found in Scutellaria baicalensis Georgi, displays neuroprotective effects on experimental models Parkinson's disease (PD) vitro and vivo. Although antioxidative and/or anti-inflammatory activity baicalein likely contributes to these effects, other modes action remain largely uncharacterized. In present study, pretreatment significantly prevented cells from 6-hydroxydopamine (6-OHDA)-induced damage by attenuating cellular apoptosis. However,...
ANLN has been identified as an actin-binding protein and previous studies have suggested that is associated with actin cytoskeletal dynamics. Lung adenocarcinoma a poor prognosis tumor. Metastasis very common complication regarded the main cause for unsatisfactory treatment outcome. Whether involved in metastasis of lung unknown.We performed immunohistochemical staining analyzed correlation between expression level pathological parameters. We tested migration invasion A549 PC9 cell after...
Herein we report the discovery of a novel lead compound, oxyphylla A [(R)-4-(2-hydroxy-5-methylphenyl)-5-methylhexanoic acid] (from fruit Alpinia oxyphylla), which functions as neuroprotective agent against Parkinson's disease. To identify shortlist candidates from extract A. oxyphylla, employed an integrated strategy combining liquid chromatography/mass spectrometry, bioactivity-guided fractionation, and chemometric analysis. The effects shortlisted were validated prior to scaling up...
SU5416 was originally designed as a potent and selective inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2) for cancer therapy. In this study, we have found the first time that unexpectedly prevented 1-methyl-4-phenylpyridinium ion (MPP+)-induced neuronal apoptosis in cerebellar granule neurons, decreased 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced loss dopaminergic neurons impairment swimming behavior zebrafish concentration-dependent manner. However,...
The zebrafish (Danio rerio) has recently become a common model in the fields of genetics, environmental science, toxicology, and especially drug screening. Zebrafish emerged as biomedically relevant for vivo high content screening simultaneous determination multiple efficacy parameters, including behaviour, selectivity, toxicity whole organism. A behavioural assay been demonstrated novel, rapid, high-throughput approach to discovery neuroactive, psychoactive, memory-modulating compounds....
Heart failure (HF) is a major public health problem worldwide. The development of HF was related to coronary microvessel dysfunction. Whether miRNAs participate in by regulating function remain unclear.The potential targets miR-665 were predicted rnahybrid software, then verified through anti-Ago2 co-immunoprecipitation, Western blotting and luciferase reporter assays. rAAV9 system used manipulate the expression vivo.Significant increase observed endothelial cells human heart with failure....
Long non-coding RNAs (lncRNAs) participate in the pathogenesis of cardiovascular diseases. However, whether circulating lncRNAs serve as dilated cardiomyopathy (DCM) biomarkers remains unclear.Totally, 266 controls and 818 patients were enrolled. First, microarray-based lncRNA profiling was performed 10 normal with DCM. Second, top 20 differentially expressed validated by real-time qPCR 64 DCM patients. Moreover, sequencing three human heart-derived cell types, correlation between levels...
Ischemic stroke is the major form of and accentuated by multiple comorbidities. It has been previously shown that different microRNAs (miRNAs) regulate separate aspects ischemic stroke. Differential miRNA expression analysis in cerebrospinal fluid patients had revealed upregulation miR-124-3p, miR-9-3p, miR-9-5p, miR-128-3p. However, whether overexpression correlative or causative was not known. Here, using an vitro oxygen-glucose deprivation/reoxygenation (OGD/R) neuronal cell model, we saw...
Abstract MicroRNAs (miRNAs) are aberrantly expressed in the pathophysiologic process of heart failure (HF). However, functions a certain miRNA different cardiac cell types during HF scarcely reported, which might be covered by globe effects it on heart. In current study, Langendorff system was applied to isolate cardiomyocytes (CMs) and fibroblasts (CFs) from transverse aortic constriction (TAC)-induced mice. Slight increase miR-320 expression observed whole tissue TAC Interestingly,...
In recent years, systematic analyses of the subcellular distribution microRNAs (miRNAs) suggest that majority miRNAs are present in both nuclear and cytoplasmic compartments. However, full extent miRNA function cardiomyocytes is currently unknown. Here, fractionation, followed by microarray, revealed most were detectable fractions cardiomyocytes. We employed miR-320 as an example to explore nucleus-localized miRNAs, finding CRISPR-Cas9-mediated Ago2 knockdown abolished miR-320-induced...
Aflatoxin B1 (AFB1) is a type of mycotoxin produced by the fungi Aspergillus flavus and parasiticus commonly found in cereals, oils foodstuffs. In order to understand toxic effects AFB1 exposure on Porcine alveolar macrophages (3D4/2 cell), 3D4/2 cells were exposed 40 μg/mL for 24 h vitro, several methods used analysis. Edu TUNEL analysis showed that proliferation was significantly inhibited apoptosis induced after compared with control group. Whole-transcriptome performed reveal non-coding...
Abstract Background The purpose of this study was to explore the reason for guanine nucleotide binding‐protein gamma subunit‐4 (GNG4) overexpression and relationship between GNG4 poor prognosis lung adenocarcinoma (LUAD) patients. Methods genes phenotypes related expression in patients with were analyzed by bioinformatics. phenotype indicated bioinformatic analysis confirmed experiments. Results is elevated adenocarcinoma, overexpressed adenocarcinoma. hypoxic microenvironment can promote...
Transforming growth factor β-activated kinase 1 (TAK1) plays a significant role in controlling several signaling pathways involved with regulating inflammation and apoptosis. As such, it represents an important potential target for developing treatments traumatic brain injury (TBI). Takinib, small molecule selective TAK1 inhibitor, has potent anti-inflammatory activity shown promising preclinical studies using rat models to evaluate the neuroprotective impact on TBI. The current study used...
Enhanced fatty acid synthesis is a hallmark of tumors, including glioblastoma. SREBF1/2 regulate the expression enzymes involved in and cholesterol synthesis. Yet, little known about precise mechanism regulating SREBP gene Here, we show that novel interaction between co-activator/co-repressor CTBP tumor suppressor ZBTB18 regulates genes. In line with our findings, metabolic assays glucose tracing analysis confirm reduction several phospholipid species upon expression. Our study identifies...
Proteolytic cleavage is an important post-translational mechanism to increase protein variability and functionality. In cancer, this process can be deregulated shut off tumor-suppressive functions. Here, we report that in glioblastoma (GBM), the tumor suppressor ZBTB18 targeted for by intracellular protease calpain. The N-terminal (Nte) cleaved fragment localizes cytoplasm thus, unable exert gene expression repressive function of uncleaved protein. Mass spectrometry (MS) analysis indicates...
Abstract Worldwide, Lung cancer is the leading cause of cancer-related death and poses a direct health threat, non-small cell lung (NSCLC) most common type. In this study, we demonstrated that centrosomal protein 20 (CEP20) upregulated in NSCLC tissues associated with invasion metastasis. Notably, CEP20 depletion inhibited proliferation, migration, microtubule polymerization. Mechanistically, discovered critical development by regulating dynamics adhesion-related signaling pathways....
Background: Cardiovascular disease (CVD) may have some association with osteoporosis (OP). This Mendelian randomization (MR) investigation aimed to explore the potential causal linkage between CVD and OP. Methods: Utilizing genome wide study data from individuals of European descent, we pinpointed Single Nucleotide Polymorphisms (SNPs) relevant CVD, including those for coronary heart (CHD) 64,762 cases 22,233 controls, failure (HF) comprising 47,309 against 930,014 stroke a case-control...