A5087400947- Cancer-related gene regulation
- Ubiquitin and proteasome pathways
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Computational Drug Discovery Methods
- Epigenetics and DNA Methylation
- Innovative Microfluidic and Catalytic Techniques Innovation
- RNA modifications and cancer
- CRISPR and Genetic Engineering
- Hepatocellular Carcinoma Treatment and Prognosis
- TGF-β signaling in diseases
- Esophageal Cancer Research and Treatment
- Cancer Mechanisms and Therapy
- Cancer, Lipids, and Metabolism
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- Kruppel-like factors research
- Cancer Immunotherapy and Biomarkers
- S100 Proteins and Annexins
- Pancreatic and Hepatic Oncology Research
- Genetic factors in colorectal cancer
- Cancer-related molecular mechanisms research
- Glycosylation and Glycoproteins Research
- Fibroblast Growth Factor Research
- Cholesterol and Lipid Metabolism
Chinese University of Hong Kong
2013-2025
University of Hong Kong
2015-2024
Tuen Mun Hospital
2019-2024
State Key Laboratory of Synthetic Chemistry
2023
University of Hong Kong - Shenzhen Hospital
2021-2023
Hong Kong Polytechnic University
2007-2022
Christian Health Association of Nigeria
2020
Alberta Hospital Edmonton
2020
China University of Geosciences
2020
Zhengzhou University
2013
This study examines the prevalence of depression, anxiety and symptoms stress among baccalaureate nursing students in Hong Kong. Recent epidemiological data suggest that mild to severe qualified nurses Kong stands at 35.8%, 37.3% 41.1%, respectively. A total 661 were recruited participate our cross-sectional mental health survey using Depression, Anxiety Stress Scale 21. Multiple logistic regression was used determine significant relationships between variables. Working general medicine,...
A novel theory in the field of tumor biology postulates that cancer growth is driven by a population stem-like cells, called tumor-initiating cells (TICs). We previously identified TIC derived from hepatocellular carcinoma (HCC) characterized membrane expression CD133. Here, we describe mechanism which these mediate and angiogenesis systematic comparison gene profiles between sorted CD133 liver subpopulations through genome-wide microarray analysis. significantly dysregulated interleukin-8...
Wnt/β‐catenin signaling is activated in CD133 liver cancer stem cells (CSCs), a subset of known to be root tumor recurrence and therapy resistance hepatocellular carcinoma (HCC). However, the regulatory mechanism this pathway CSCs remains unclear. Here, we show that human microRNA (miRNA), miR‐1246, promotes stemness, including self‐renewal, drug resistance, tumorigencity, metastasis, by activation through suppressing expression AXIN2 glycogen synthase kinase 3β (GSK3β), two key members...
Abstract Targetable drivers governing 5-fluorouracil and cisplatin (5FU + CDDP) resistance remain elusive due to the paucity of physiologically therapeutically relevant models. Here, we establish 5FU CDDP resistant intestinal subtype GC patient-derived organoid lines. JAK/STAT signaling its downstream, adenosine deaminases acting on RNA 1 (ADAR1), are shown be concomitantly upregulated in ADAR1 confers chemoresistance self-renewal an editing-dependent manner. WES coupled with RNA-seq...
Identification of therapeutic targets against tumor-initiating cells (TICs) is a priority in the development new paradigms cancer. We enriched TIC population capable tumor initiation and self-renewal by serial passages hepatospheres with chemotherapeutic agents. In chemoresistant hepatospheres, CD47 was found to be up-regulated, when compared differentiated progenies. preferentially expressed liver TICs, which contributed initiation, self-renewal, metastasis significantly affected patients'...
Abstract Tumor-initiating cells (TIC), also known as cancer stem cells, are regarded widely a specific subpopulation of needed for initiation and progression. TICs have yet to be identified in esophageal tumors that an increasing incidence developed countries. Here, we report CD90+ cell population found squamous carcinoma (ESCC), which is endowed with cell–like properties high tumorigenic metastatic potential. mRNA profiling these suggested pathways through they drive tumor growth...
Esophageal squamous cell carcinoma (ESCC), the major histologic subtype of esophageal cancer, is a devastating disease characterized by distinctly high incidences and mortality rates. However, there remains limited understanding molecular events leading to development progression disease, which are paramount importance defining biomarkers for diagnosis, prognosis, personalized treatment. By high-throughout transcriptome sequence profiling nontumor ESCC clinical samples, we identified subset...
Abstract The survival benefit derived from sorafenib treatment for patients with hepatocellular carcinoma (HCC) is modest due to acquired resistance. Targeting cancer stem cells (CSC) a possible way reverse drug resistance, however, inhibitors that specifically target liver CSCs are limited. In this study, we established two sorafenib-resistant, patient-derived tumor xenografts (PDX) mimicked development of resistance in HCC. RNA-sequencing analysis sorafenib-resistant PDXs and their...
Background and Aims The survival benefit of sorafenib for patients with hepatocellular carcinoma (HCC) is unsatisfactory due to the development adaptive resistance. Increasing evidence has demonstrated that drug resistance can be acquired by cancer cells activating a number signaling pathways through receptor tyrosine kinases (RTKs); nevertheless, detailed mechanism activation these alternative not fully understood. Approach Results Given physiological role Src homology 2 domain–containing...
Rapidly growing tumors often experience hypoxia and nutrient (e.g., glucose) deficiency because of poor vascularization. Tumor cells respond to the cytotoxic effects such stresses by inducing molecular adaptations that promote clonal selection a more malignant tumor-initiating cell phenotype, especially in innermost tumor regions. Here, we report regulatory mechanism involving fucosylation which glucose restriction promotes cancer stemness drive drug resistance recurrence. Using...
Abstract Accumulating evidence has demonstrated that drug resistance can be acquired in cancer through the repopulation of tumors by stem cell (CSC) expansion. Here, we investigated mechanisms driving and CSC hepatocellular carcinoma (HCC) as a model using two drug-resistant, patient-derived tumor xenografts mimicked development to sorafenib or lenvatinib treatment observed patients with HCC. RNA sequencing analysis revealed cholesterol biosynthesis was most commonly enriched drug-resistant...
Sorafenib, a first-line molecular-target drug for advanced hepatocellular carcinoma (HCC), has been shown to be potent ferroptosis inducer in HCC. However, we found that there was lower level of sorafenib-resistant HCC samples than sorafenib-sensitive samples, suggesting sorafenib resistance may result suppression. Recent reports have long noncoding RNAs (lncRNAs) are involved programmed cell death (PCD), including apoptosis and ferroptosis. This study aimed investigate the roles underlying...
Abstract Hepatocellular carcinoma (HCC) is an aggressive malignancy without effective therapeutic approaches. Here, we evaluate the tumor-intrinsic mechanisms that attenuate efficacy of immune checkpoint inhibitor (ICI) observed in patients with advanced HCC who progress on first-line tyrosine kinase (TKI) therapy. Upregulation AXL sorafenib- and lenvatinib-resistant HCCs correlated poor response towards TKI ICI treatments. upregulation protects sorafenib-resistant cells from oxidative...
Frequent tumor relapse in hepatocellular carcinoma (HCC) has been commonly attributed to the presence of residual cancer stem cells (CSCs) after conventional treatments. We have previously identified and characterized CD133 mark a specific CSC subset HCC. In present study, we found endogenous secretory annexin A3 (ANXA3) play pivotal roles promoting cell-like features CD133+ liver CSCs through dysregulated JNK pathway. Blockade ANXA3 with an anti-ANXA3 monoclonal antibody vitro as well human...
// Stella Chai 1,* , Man Tong Kai Yu Ng Pak Shing Kwan 2 Yuen Piu Chan 3 Tsun Ming Fung 1 Terence K. Lee 3,4,5 Nathalie Wong 6 Dan Xie 7 Yun-Fei Yuan Xin-Yuan Guan 2,4,5 and Stephanie Ma 1,4,5 Department of Anatomy, The University Hong Kong, Kong Clinical Oncology, Departments Pathology, 4 State Key Laboratory for Liver Research, 5 Centre Cancer Li Ka Faculty Medicine, Anatomical Cellular Chinese Oncology in South China, Sun Yat-Sen Centre, Guangzhou, China * These authors contributed...
Oesophageal squamous cell carcinoma (ESCC) is the most common histological subtype of oesophageal cancer. The disease particularly prevalent in southern China. incidence on rise and its overall survival rate remains dismal. Identification characterization better molecular markers for early detection therapeutic targeting are urgently needed. Here, we report levels transmembrane soluble neuropilin-2 (NRP2) to be significantly up-regulated ESCC, correlate positively with advanced tumour stage,...
The tumor microenvironment plays a critical role in maintaining the immature phenotype of tumor-initiating cells (TIC) to promote cancer. Hepatocellular carcinoma (HCC) is unique disease that it develops setting fibrosis and cirrhosis. This pathologic state commonly shows an enrichment stromal myofibroblasts, which constitute bulk contribute progression. Follistatin-like 1 (FSTL1) has been widely reported as proinflammatory mediator different fibrosis-related inflammatory diseases. Here we...
Hepatocellular carcinoma (HCC) has high intratumoral heterogeneity, which contributes to therapeutic resistance and tumour recurrence. We previously identified Prominin-1 (PROM1)/CD133 as an important liver cancer stem cell (CSC) marker in human HCC. The aim of this study was investigate the heterogeneity properties Prom1+ cells HCC intact mouse models.We established two models representing chronic fibrotic rapid steatosis-related performed lineage tracing post-HCC induction using...
Esophageal squamous cell carcinoma (ESCC) has a generally poor prognosis, and molecular markers to improve early detection predict outcomes are greatly needed. Here, we report that the BMP-binding follistatin-like protein FSTL1 is overexpressed in ESCCs, where it correlates with overall survival. Genetic amplification of or chromosome 3q, located, occurred frequently ESCC, copy number correlated positively higher expression. Elevating levels by various means was sufficient drive ESCC...
// Kai-Yu Ng 1 , Stella Chai Man Tong Xin-Yuan Guan 2, 3 Chi-Ho Lin 4 Yick-Pang Ching 1, Dan Xie 5 Alfred Sze-Lok Cheng 6 Stephanie Ma School of Biomedical Sciences, Li Ka Shing Faculty Medicine, The University Hong Kong, Pok Fu Lam, Kong 2 Department Clinical Oncology, State Key Laboratory for Liver Research, Centre Genomic Oncology in Southern China, Sun Yat-Sen Cancer Center, Guangzhou, China Chinese Sha Tin, Correspondence to: Ma, e-mail: stefma@hku.hk Keywords: cancer stem cells, HBx,...
Abstract The physical microenvironment is a critical mediator of tumor behavior. However, detailed biological and mechanistic insight lacking. present study reveals the role chemotherapy‐enriched CD133+ liver cancer stem cells (CSCs) with THBS2 deficiency. This subpopulation contributes to more aggressive functional stemness phenotype in hepatocellular carcinoma (HCC) by remodeling extracellular matrix (ECM) through regulation metalloproteinase (MMP) activity, collagen degradation,...