A5028142218- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Chemokine receptors and signaling
- Amino Acid Enzymes and Metabolism
- Cancer Research and Treatments
- Nanoplatforms for cancer theranostics
- Cancer, Hypoxia, and Metabolism
- Immune Cell Function and Interaction
- Photodynamic Therapy Research Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Glioma Diagnosis and Treatment
- Hepatitis B Virus Studies
- Adenosine and Purinergic Signaling
- Cancer, Stress, Anesthesia, and Immune Response
- 3D Printing in Biomedical Research
- Histone Deacetylase Inhibitors Research
- Liver physiology and pathology
- Epigenetics and DNA Methylation
- Phagocytosis and Immune Regulation
- Pancreatic and Hepatic Oncology Research
- Angiogenesis and VEGF in Cancer
- Cancer Cells and Metastasis
- Porphyrin and Phthalocyanine Chemistry
- Cancer Mechanisms and Therapy
- Virus-based gene therapy research
Chinese University of Hong Kong
2017-2025
Prince of Wales Hospital
2024-2025
Objective Therapy-induced tumour microenvironment (TME) remodelling poses a major hurdle for cancer cure. As the majority of patients with hepatocellular carcinoma (HCC) exhibits primary or acquired resistance to antiprogrammed cell death (ligand)-1 (anti-PD-[L]1) therapies, we aimed investigate mechanisms underlying adaptation immune-checkpoint targeting. Design Two immunotherapy-resistant HCC models were generated by serial orthotopic implantation cells through anti-PD-L1-treated...
Genomic screening uncovered interferon-gamma (IFNγ) pathway defects in tumours refractory to immune checkpoint blockade (ICB). However, its non-mutational regulation and reversibility for therapeutic development remain less understood.
Durable response to immune checkpoint blockade (ICB) in hepatocellular carcinoma (HCC) are limited a minority of patients, yet reliable biomarkers still lacking. Inflammatory cytokines such as interleukin-8 (IL-8) associated with HCC progression, and IL-8 is known the chemoattractant for immunosuppressive myeloid cells. Therefore, we aim elucidate ICB resistance mechanisms mediated by activation IL-8/CXCR2 pathway. Single-cell RNA sequencing (scRNA-seq) were performed advanced patients...
Recent studies demonstrated the importance of fibrosis in promoting an immunosuppressive liver microenvironment and thereby aggressive hepatocellular carcinoma (HCC) growth resistance to immune checkpoint blockade (ICB), particularly via monocyte-to-monocytic myeloid-derived suppressor cell (M-MDSC) differentiation triggered by hepatic stellate cells (HSCs). We thus aimed identify druggable targets these myeloid for HCC therapy.
Immune checkpoint blockade (ICB) has been approved for treatment of hepatocellular carcinoma (HCC). However, many patients with advanced HCC are non-responders to ICB monotherapy. Cytotoxic chemotherapy proposed modulate the tumor microenvironment (TME) and sensitize tumors ICB. Thus, we aimed study combination cytotoxic in an orthotopic model.
A phthalaldehyde-substituted phthalocyanine has been synthesized that can conjugate with a range of biomolecules, including peptides, monosaccharides, lipids, and DNAs, be immobilized on the surface bovine serum album nanoparticles glass slides using versatile efficient phthalaldehyde-amine capture reactions. The light-induced cytotoxic effects latter two materials have also examined against cancer cells bacteria, respectively, showing they are highly photosensitizing systems for...
Abstract Arginine deprivation using arginase emerges as a potential cancer treatment approach, some cancers have been found to be arginine-auxotrophic, relying on exogenous arginine for their growth. In this study, we evaluated the combination of pegylated recombinant human (PEG-BCT-100), which is currently undergoing clinical trials with toxic analog, canavanine in pancreatic cancer. Remarkable synergistic anti-tumor effect was observed both vitro and vivo. Specifically, induced apoptotic...
<h3>Background</h3> The heterogeneity and diverse pathogenic conditions of HCC construct an immunosuppressive tumor microenvironment (TME) which may lead to low immune checkpoint blockade (ICB) therapeutic responsiveness. Therefore, alleviating immunosuppression potentiate ICB anti-cancer immunity is in urgent need. Myeloid-derived suppressor cells (MDSCs) with potent T cell suppressive property are correlated poor prognosis unsatisfactory response HCC. In this study, we aimed study the...
Abstract Background: Arginine deprivation is a novel approach for cancer treatment as some cancers were found to be arginine auxotrophic. PEG-BCT-100, pegylated form of recombinant human arginase, was used investigate the effect on pancreatic cell lines. On other hand, Canavanine (CAV), natural toxic analog isolated from leguminous plant, has also demonstrated its ability in inhibiting proliferation. It alters protein structure and causes critical metabolic defects cells by replacing into...
Abstract Introduction: Intrinsic immunologic composition in liver tumor microenvironment (TME) may play a role the heterogenous response towards immune-checkpoint blockade hepatocellular carcinoma (HCC). In some cancers, it has been shown that cytotoxic chemotherapy is synergistic with checkpoint inhibitors. this study, we evaluated efficacy and immunomodulation of 5-FU anti-PD-L1 orthotopic cancer mouse model. Method: The model was established murine HCC cell line RIL-175 through...