A5108054312- High voltage insulation and dielectric phenomena
- Barrier Structure and Function Studies
- Drug Transport and Resistance Mechanisms
- Fungal Biology and Applications
- Aerosol Filtration and Electrostatic Precipitation
- Liver Disease Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Acute Myeloid Leukemia Research
- Viral gastroenteritis research and epidemiology
- Organic Electronics and Photovoltaics
- Optical properties and cooling technologies in crystalline materials
- Fatty Acid Research and Health
- Plasma Applications and Diagnostics
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Orbital Angular Momentum in Optics
- Conducting polymers and applications
- Luminescence Properties of Advanced Materials
- Hematopoietic Stem Cell Transplantation
- Animal Virus Infections Studies
- Nutritional Studies and Diet
- Perovskite Materials and Applications
- Epigenetics and DNA Methylation
- Immune Cell Function and Interaction
- Viral Infections and Immunology Research
First Affiliated Hospital of Hebei Medical University
2025
Hebei Medical University
2025
Capital Medical University
2021-2025
Xinjiang Medical University
2025
Beijing Tongren Hospital
2021-2025
Southern Medical University
2018-2024
Nanfang Hospital
2023-2024
Nanjing Agricultural University
2024
Tianjin University
2023-2024
Binzhou People's Hospital
2024
Acetaminophen (APAP) overdose is a leading cause of drug-induced liver injury (DILI). The impact the gut microbiota and associated metabolites on APAP function remains unclear. We show that disturbance with distinct microbial community, notable decreases in Lactobacillus vaginalis. Mice receiving L. vaginalis showed resistance to hepatotoxicity due liberation isoflavone daidzein from diet by bacterial β-galactosidase. hepatoprotective effects APAP-exposed germ-free mice were abolished...
Abstract Previously, we have identified ZFAS1 as a potential new long non-coding RNA (lncRNA) biomarker of acute myocardial infarction (MI) and sarcoplasmic reticulum Ca 2+ -ATPase 2a (SERCA2a) inhibitor, causing intracellular overload contractile dysfunction in mouse model MI. In the current study, aimed to evaluate effects on apoptosis cardiomyocytes MI model. Knockdown endogenous by virus-mediated silencing shRNA or si partially abrogated ischemia-induced cardiomyocytes. Overexpression...
Claudin-6 (CLDN6), a member of CLDN family and key component tight junction, has been reported to function as tumor suppressor in breast cancer. However, whether CLDN6 plays any role cancer chemoresistance remains unclear. In this study, we investigated the acquisition cells. We manipulated expression MCF-7 MCF-7/MDR cells with lv-CLDN6 CLDN6-shRNA manipulation lead different susceptibilities several chemotherapeutic agents these The cytotoxicity adriamycin (ADM), 5-fluorouracil (5-FU),...
Human noroviruses (NoVs), a major cause of viral gastroenteritis, are difficult to study due the lack cell-culture and small-animal model. Pigs share with humans types A H histo-blood group antigens on intestinal epithelium have been suggested as potential model for studies NoV pathogenesis, immunity vaccines. In this study, effects age cholesterol-lowering drug, simvastatin, susceptibility pigs infection were evaluated. The median infectious dose (ID50) genogroup II, genotype 4 (GII.4)...
A method to generate orbital angular momentum (OAM) radio waves based on dielectric resonator antenna is demonstrated. An equivalent model built investigate this OAM in detail. Simulation and measurement are also carried out for antenna. Both simulated results show typical efficient radiation of OAM-carrying waves. It can with different mode numbers at frequencies. Because its compact structure, low cost, small size, will be a cost-effective solution wave generation.
Abstract Optical thermometry has emerged as a promising technology to overcome the limitations of traditional techniques. Herein, we report an Eu 3+ -activated tungstate Ba 2 CaWO 6 phosphors for luminescent with maximum relative sensitivity 4.84% based on single-band ratiometric technique. By monitoring 5 D 0 → 7 F 1 (595 nm) emission , excitation spectrum as-prepared sample was measured, showing dominant broad band ranging from 240 345 nm corresponding O 2− -W 6+ charge transfer (CTB). The...
Abstract In strong wind environments, changes in airflow patterns can affect the degree of deflection insulator skirts. Deflection or tearing composite skirts reduce their insulation performance. This article takes double I-string 330 kV transmission line as research object. The angles are set 0°, 16°, 30°, 60°, and 90°. speeds 5m/s, 10m/s, 20m/s, 30m/s, 40m/s. simulation results show that under 0° windward angle condition, upstream completely blocks airflow. flow state near with variation...
Effective health management for high-risk stroke populations is essential. The hospital-community-home (HCH) collaborative (CHM) model leverages resources from hospitals, communities, and families. By integrating patient information across these three domains, it facilitates the delivery of tailored guidance, risk assessments, three-in-one education. To explore effects HCH-CHM on reduction in populations. In total, 110 patients screened community January 2019 to 2023 were enrolled, with 52...
Nitroreductase (NTR) is overexpressed in hypoxic tumors. Moreover, hypoxia usually considered as the most important feature of various diseases. Thus, it to build a sensitive and selective method for NTR detection diagnosis. Herein, new cationic conjugated polymer (PBFBT-NP) with p-nitrophenyl group side chain was designed synthesized fluorescent probe NTR. In absence NTR, fluorescence PBFBT-NP quenched due photoinduced electron transfer (PET). On contrary, presence can specifically react...
Multidrug resistance (MDR) is a major problem in the treatment of breast cancer. In present study, next-generation sequencing technology was employed to identify differentially expressed genes MCF‑7/MDR cells and MCF‑7 cells, aimed investigate underlying molecular mechanisms MDR Differentially between were selected using software; total 2085 screened as cells. Furthermore, gene ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment analyses performed DAVID database....
Near-infrared electron acceptors for organic solar cells (OSCs) mostly contain electron-withdrawing 2-(3-oxo-2,3-dihydro-1H-inden-1-ylidene)malononitrile (IC) end groups, which can be modified by but limited to phenyl, thienyl, and naphthyl units with halogenated, methyl, methyloxy substitution. In this work, we employed an imide-containing unit construct a new IC group, based on series of were synthesized. The strong electron-deficient nature imide enables the show efficient intramolecular...
Abstract Objective POU5F1 (OCT4) is implicated in cancer stem cell self‐renewal. Currently, some studies have shown that OCT4 has a dual function suppressing or promoting progression. However, the precise molecular mechanism of breast progression remains unclear. Materials and Methods RT‐PCR Western blot were utilized to investigate expression tissues cells. Cell proliferation assays mouse models applied determine effects on proliferation. DNMT1 inhibitors, ChIP, CoIP, IHC ERα inhibitors...
Purpose Immune dysregulation plays a key role in acute myeloid leukemia (AML). We aimed to explore the correlation between T helper cell 17 (Th17) and regulatory cells (Tregs) peripheral blood of patients with newly diagnosed (ND) AML bone marrow blast cells, as well minimal residual disease (MRD) before after treatment.
Abstract Acetaminophen (APAP)-induced liver injury (AILI) is a pressing public health concern. Although evidence suggests that Bifidobacterium adolescentis ( B. ) can be used to treat disease, it unclear if prevent AILI. In this report, we prove significantly attenuated AILI in mice, as demonstrated through biochemical analysis, histopathology, and enzyme-linked immunosorbent assays. Based on untargeted metabolomics vitro cultures, found generates microbial metabolite hypaphorine....
The optimal treatment for elderly patients with acute myeloid leukemia (AML) remains a great challenge. Establishing more feasible, acceptable, accessible and safe strategy is urgently needed. We conducted prospective study of 23 (median age, 68 years; range, 60 to 87 years) newly diagnosed AML evaluate the efficacy toxicity decitabine plus granulocyte colony-stimulating factor priming, low-dose aclarubicin, cytarabine (DCAG) chemotherapy combined HLA-mismatched stem cell...
Unique insights into the monitoring of a typical fermentation process natto based on low field nuclear magnetic resonance (LF-NMR) associated with imaging (MRI).
Capsaicinoids, mostly from chili peppers, are widely used in daily life. Capsaicinoids considered to be markers for the identification of illegal cooking oil (ICO), which is a serious threat public health. The capsaicinoids can help reveal food-related fraud, thereby safeguarding consumers’ Here, novel and ultrasensitive method was established with signal amplification strategy detection capsaicinoids. AuNPs@Fe3O4 nanocomposites were functionalized 4-aminothiophenol (4-atp). After...