A5082669738- Luminescence and Fluorescent Materials
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Molecular Sensors and Ion Detection
- Climate variability and models
- Photodynamic Therapy Research Studies
- DNA and Nucleic Acid Chemistry
- Polydiacetylene-based materials and applications
- Meteorological Phenomena and Simulations
- Antimicrobial agents and applications
- Conducting polymers and applications
- Antimicrobial Peptides and Activities
- Supramolecular Self-Assembly in Materials
- Atmospheric and Environmental Gas Dynamics
- RNA Interference and Gene Delivery
- Porphyrin and Phthalocyanine Chemistry
- Oceanographic and Atmospheric Processes
- Electrochemical Analysis and Applications
- Atmospheric aerosols and clouds
- Carbon and Quantum Dots Applications
- Advanced Differential Equations and Dynamical Systems
- Advanced Nanomaterials in Catalysis
- Click Chemistry and Applications
- Luminescence Properties of Advanced Materials
- Bone Tissue Engineering Materials
Shaanxi Normal University
2016-2025
Capital University of Physical Education and Sports
2024
Beijing Friendship Hospital
2024
Capital Medical University
2024
Shenzhen Maternity and Child Healthcare Hospital
2022-2023
Chinese Academy of Meteorological Sciences
2019-2022
Philippine Christian University
2022
Linyi University
2022
University of Science and Technology of China
2021
Hefei National Center for Physical Sciences at Nanoscale
2021
Single-stranded DNA with G-rich sequences can fold into secondary structures, G-quadruplexes, via intramolecular hydrogen-bonding interactions. This conformational change be detected by a homogeneous assay method based on fluorescence resonance energy transfer (FRET) from water-soluble cationic conjugated polymer (CCP) to fluorescein chromophore labeled at the terminus of G-quadruplex DNA. The space charge density around controls efficiency FRET CCP fluorescein. higher for CCP/G-quadruplex...
A conjugated-polymer-based “mix-and-detect” optical sensor for mercury ions is fabricated by using a water-soluble poly[3-(3′-N,N,N-triethylamino-1′-propyloxy)-4-methyl-2,5-thiophene hydrochloride] (PMNT) and label-free, mercury-specific oligonucleotide (MSO) probe. PMNT binds to the Hg2+-free MSO Hg2+–MSO complex in different ways, exhibits distinguishable specific responses target-induced conformation change. Supporting information this article available on WWW under...
Abstract This paper introduces the Flexible Global Ocean‐Atmosphere‐Land System Model: Grid‐Point Version 3 (FGOALS‐g3) and evaluates its basic performance based on some of participation in sixth phase Coupled Model Intercomparison Project (CMIP6) experiments. Our results show that many significant improvements have been achieved by FGOALS‐g3 terms climatological mean states, variabilities, long‐term trends. For example, has a small (−0.015°C/100 yr) climate drift 700‐yr preindustrial...
Deep-tissue optical imaging and photodynamic therapy (PDT) remain a big challenge for the diagnosis treatment of cancer. Chemiluminescence (CL) has emerged as promising tool biological in vivo therapy. The development covalent-binding chemiluminescence agents with high stability resonance energy transfer (CRET) efficiency is urgent. Herein, we design synthesize an unprecedented chemiluminescent conjugated polymer PFV-Luminol, which consists polyfluorene vinylene (PFV) main chains...
By making use of the aggregation-induced emission feature silole, compound 1 with an ammonium group is designed and synthesized a view to developing new optical probe for fluorescence turn-on detection DNA label-free nuclease assay. The increases largely upon mixing DNA, in particular long indicating that can be used DNA. More interestingly, employed follow cleavage process by nuclease. Therefore, assay method successfully established 1. Furthermore, this also inhibitor screening nucleases....
Abstract Summary: A reversible and highly selective assay method has been developed to detect mercury( II ) (Hg 2+ ions using a conjugated polymer (CP). The transduction mechanism is based on Hg ‐mediated interpolymer π ‐stacking aggregation, which results in the fluorescence self‐quenching of CP. CPs that contain thymine moieties, poly[3‐( N ‐thymin‐1‐ylacetyl)ethylamine‐thiophene] (PTT), have synthesized characterized. In absence ions, PTT chains remain separated from each other CP...
A new method has been developed for the label-free, convenient, and real-time monitoring of cleavage single-stranded DNA by single-strand-specific S1 nuclease hydroxyl radical based on cationic water-soluble poly[3-(3'-N,N,N-triethylamino-1'-propyloxy)-4-methyl-2,5-thiophene hydrochloride] (PMNT). The PMNT can form an interpolyelectrolyte complex with ssDNA (duplex) through electrostatic interactions, in which takes a highly conjugated planar conformation, thus exhibits relatively...
Quick but sensitive: A super-quenched fluorogenic complex of a cationic acetylcholine (ACh) derivative with an energy-acceptor tag and anionic water-soluble conjugated polymer forms the basis highly effective fluorescence turn-on assay for studying enzyme kinetics inhibition acetylcholinesterase (AChE; see schematic representation assay). FRET=fluorescence resonant energy transfer. Supporting information this article is available on WWW under...
A new fluorescent nanoparticle based on lipid-modified cationic poly(fluorenylene phenylene) (PFPL) was prepared and characterized. The PFPL is amphiphilic has two unique structural features. First, the lipid designed as a side chain in consideration of fact that biocompatible can enter cytoplasm easily also provides protective layers to conjugated polymer backbones. Second, ammonium pendant groups interface with genes offer vector for gene delivery. forms uniform nanoparticles water size...
Abstract COVID‐19 pandemic outbreak poses a great threat to human health. Face masks have been considered as important personal protective equipment prevent the transmission. However, pathogens can survive up several days on fabrics of commercial masks, which increases risk direct/indirect microbial Herein, new cationic conjugated microporous polymers (CCMPs)‐based coating is developed, possesses extended π‐conjugated skeletons and massive quaternary ammonium salt (QAS) groups, exhibiting...
A novel all-in-one phototheranostics OTAB was synthesized by modifying the donor and regulating band gap for NIR-II imaging-guided synergistic type-I PDT/PTT therapy.
G-quartet DNA converts to duplex form in the presence of its complementary strand. This conformational change can be detected real time by a homogeneous assay method based on signal amplification conjugated polyelectrolytes and specific interaction intercalating dyes with double-stranded (dsDNA). The probe solution contains cationic, polymer (CCP), G-quadruplex labeled fluorescein at 5'-terminus (G-quadruplex-Fl), ethidium bromide (EB). addition target results transition from (dsDNA-Fl) EB...
A new method is developed for sensitive, homogeneous, and convenient assays of nucleases methyltransferases using complexes cationic conjugated polymers with DNA containing a fluorescein tag at the 5′-terminus (DNA-Fl). The cleavage by can be monitored fluorescence spectra observing conjugated-polymer or emission changes in aqueous solutions.
A new method has been developed for continuous and real-time assays enzymes using complexes of conjugated polymers/enzymatic substrates by electrostatic interactions, where the products are substrate fragments free chains polymers. The charged as a proof concept anionic adenosine triphosphate (ATP) alkaline phosphatase (ALP), well cationic polyarginine peptide (Arg6) trypsin. water-soluble polyfluorenes containing 2,1,3-benzothiadiazole (BT) units demonstrate intramolecular energy transfer...
The bactericidal mechanisms of poly(phenylene ethynylene) (PPE)-based cationic conjugated polyelectrolytes (CPE) and oligo-phenylene ethynylenes (OPE) were investigated using electron/optical microscopy small-angle X-ray scattering (SAXS). ultrastructural analysis shows that polymeric PPE-Th can significantly remodel the bacterial outer membrane and/or peptidoglycan layer, followed by possible collapse cytoplasm membrane. In contrast, oligomeric end-only OPE (EO-OPE) possesses potent...
We designed and synthesized a novel oligo(thiophene ethynylene) (OTE) to investigate the antibacterial activities against Gram-positive (Staphylococcus aureus Staphylococcus epidermidis) Gram-negative (Ralstonia solanacearum Escherichia coli) bacteria in vitro by photodynamic therapy (PDT). Notably, OTE presents broad-spectrum greatly high after white light irradiation at nanogram per milliliter concentrations. The half inhibitory concentrations (IC50) values obtained for S. aureus,...
The Earth-Climate System Model (ECSM) is an important platform for multi-disciplinary and multi-sphere integration research, its development at the frontier of international geosciences, especially in field global change. research (R&D) ECSM China began 1980s have achieved great progress. In China, ECSMs are now mainly developed Chinese Academy Sciences, ministries, universities. Following a brief review history ECSMs, this paper summarized technical characteristics nine participating...
Abstract Diabetic chronic wounds are characterized by local hypoxia, impaired angiogenesis, and bacterial infection. In situ, self‐supply of dissolved oxygen combined with the elimination bacteria is urgent challenging for nonhealing wound treatment. Herein, an oxygen‐generating system named HA‐L‐NB/PFE@cp involving biological photosynthetic chloroplasts (cp)/conjugated polymer composite nanoparticles (PFE‐1‐NPs@cp) light‐triggered hyaluronic acid‐based (HA‐L‐NB) hydrogel promoting diabetic...
It is essential to develop alternative strategies treat infections, especially those infections caused by Staphylococcus aureus, which responsible for most skin infections. Among strategies, light-induced inactivation of pathogens appears be a promising candidate. We present four novel "end only" oligo(phenylene ethynylene)s (EO-OPE-1s) that have the ends functionalized with cationic groups and are powerful light-activated biocides against Escherichia coli, epidermidis, S. aureus. correlated...
Poly(phenylene ethyneylene) (PPE)-based cationic conjugated polyelectrolytes (CPEs) and phenylene ethynylene oligomers (OPEs) exhibit broad-spectrum antimicrobial activity, their main target is believed to be the cell membrane. To understand better how these molecules interact with membranes, a series of PPE-based CPEs OPEs different side chains were studied. Large unilamellar vesicles lipid compositions mimicking those mammalian or bacterial membranes used as model membranes. Among tested,...
The antiviral activities of poly(phenylene ethynylene) (PPE)-based cationic conjugated polyelectrolytes (CPE) and oligo-phenylene ethynylenes (OPE) were investigated using two model viruses, the T4 MS2 bacteriophages. Under UV/visible light irradiation, significant activity was observed for all CPEs OPEs; without most these compounds exhibited high inactivation against phage moderate ability phage. Transmission electron microscopy (TEM) SDS polyacrylamide gel electrophoresis (SDS-PAGE)...
The light-induced antibacterial activity of symmetric and asymmetric oligophenylene ethynylenes (OPEs) was investigated against Gram-positive (Staphylococcus aureus Staphylococcus epidermidis) Gram-negative (Escherichia coli) bacteria. To understand the biocidal effect better, transient absorption triplet lifetime OPEs were studied in methanol water. A higher observed for OPE samples water than methanol. magnitudes changes optical density (ΔOD) S-OPE-n(H) series oligomers are much that OPE-n...
Three series of cationic oligo p-phenyleneethynylenes (OPEs) have been synthesized to study their structure−property relationships and gain insights into the transition from molecular macromolecular properties. The absorbance maxima molar extinction coefficients in all three sets increase with increasing number repeat units; however, λmax between oligomers having 2 3 units is very small, oligomer shows virtually same spectra as a p-phenyleneethynylene polymer 49 units. A computational using...
Prefoldin (PFDN) is a co-chaperone protein that primarily known for its classic cytoplasmic functions in the folding of actin and tubulin monomers during cytoskeletal assembly. Here, we report marked increase prefoldin subunit 1 (PFDN1) levels transforming growth factor (TGF)-β1-mediated epithelial-mesenchymal transition (EMT) human lung tumor tissues. Interestingly, nuclear localization PFDN1 was also detected. These observations suggest may be essential important novel functions....