A5059687360- Sepsis Diagnosis and Treatment
- Immune Response and Inflammation
- Intensive Care Unit Cognitive Disorders
- Inflammation biomarkers and pathways
- Respiratory Support and Mechanisms
- High-Voltage Power Transmission Systems
- HVDC Systems and Fault Protection
- Nosocomial Infections in ICU
- Galectins and Cancer Biology
- Axon Guidance and Neuronal Signaling
- Immune cells in cancer
- S100 Proteins and Annexins
- Heart Failure Treatment and Management
- Smart Grid and Power Systems
- Clinical Reasoning and Diagnostic Skills
- Cancer, Stress, Anesthesia, and Immune Response
- Immune Cell Function and Interaction
- Neuroinflammation and Neurodegeneration Mechanisms
- Mechanical Circulatory Support Devices
- interferon and immune responses
- Pneumonia and Respiratory Infections
- Cardiovascular Function and Risk Factors
- Cardiac Ischemia and Reperfusion
- Medication Adherence and Compliance
- Angiogenesis and VEGF in Cancer
Tianjin Medical University General Hospital
2016-2025
Zhengzhou Central Hospital
2019-2023
Beijing Tsinghua Chang Gung Hospital
2023
Tsinghua University
2023
China Southern Power Grid (China)
2010
Electric Power Research Institute
2008
Abstract Background There is no available viable treatment for Sepsis-Induced Cardiomyopathy (SIC), a common sepsis complication with higher fatality risk. The septic patients showed an abnormal activation of the renin angiotensin (Ang) aldosterone system (RAAS). However, it not known how Ang II and Ang-(1–7) affect SIC. Methods Peripheral plasma was collected from Healthy Control (HC) protein concentrations were measured. in vitro vivo models SIC developed using Lipopolysaccharide (LPS) to...
T cell immunoglobulin mucin-3 (Tim-3) has previously been implicated in the immune response and tumor biology. Colorectal carcinoma (CRC) is a malignancy, which closely associated with inflammation. However, role of Tim‑3 progression CRC remains to be fully elucidated. The present study aimed investigate progressive activities human CRC. A total 30 clinical tissues their adjacent were collected. Slides from another 112 cases that underwent surgical resection also obtained. protein mRNA...
Cellular immunosuppression appears to be involved in sepsis and sepsis-induced multiple organ dysfunction syndrome (MODS). Recent evidence showed that parenteral vitamin C (Vit C) had the ability attenuate MODS. Herein, we investigated impact of Vit on cellular therapeutic value sepsis. Using cecal ligation puncture (CLP), was induced WT Gulo −/− mice followed with 200 mg/Kg administration. The immunologic functions CD4 + CD25 regulatory T cells (Tregs) − cells, as well functions, were...
Sepsis-induced cardiomyopathy (SIC) is a life-threatening cardiac complication of sepsis with limited therapeutic options. Dapagliflozin, sodium-glucose cotransporter 2 (SGLT2) inhibitor, has demonstrated cardioprotective effects in heart failure, but its role mitigating sepsis-related dysfunction remains unclear. A retrospective cohort analysis was conducted to assess the impact pre-hospital dapagliflozin use on major adverse cardiovascular events (MACEs) and survival patients SIC....
Rutin is a flavanol-type polyphenol that consists of flavanol quercetin and the disaccharide rutinose, which has been reported to exert various biological effects such as antioxidant anti-inflammatory activities. It not clear whether rutin protective effect on sepsis-induced cardiomyopathy (SIC). In this study, we used male C57BL/6 mice cecal ligation puncture (CLP) surgery establish model SIC. was precautionarily treated (50, 100, 200 mg/kg per day, 7 days) before CLP. The results showed...
Xuebijing (XBJ) injection, a concoction of several Chinese herbs, has been widely used as an immunomodulator for the treatment severe sepsis in China. However, precise mechanisms responsible its efficacy have not fully elucidated. In our study, we determined flow cytometry markers (F4/80, CD11c, and CD206), levels secreted cytokines (TNF-α, IL-6, IL-10), expression specific proteins M2 (Ym1, Fizz1, Arg1) to assess macrophage polarization. Treatment with XBJ lowered M1 associated cytokine...
Regulatory T cells (Tregs) appear to be involved in sepsis-induced immune dysfunction; neuropilin-1 (Nrp-1) was identified as a surface marker for <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi mathvariant="normal">C</mml:mi><mml:mi mathvariant="normal">D</mml:mi><mml:msup><mml:mrow><mml:mn mathvariant="normal">4</mml:mn></mml:mrow><mml:mrow><mml:mo>+</mml:mo></mml:mrow></mml:msup><mml:mi...
Our previous research showed that neuropilin (Nrp) -1highCD4+CD25+Regulatory T cells (Tregs) exhibited primary negative immunoregulation in sepsis induced immune dysfunction. Tuftsin is the typical ligand of Nrp-1. Herein, we investigated potential therapeutic value and mechanisms tuftsin sepsis. Sepsis per se markedly decreased serum concentration tuftsin, administration improved survival rate septic mice with cecal ligation puncture (CLP). In vitro study, prevented Nrp-1highCD4+CD25+Tregs,...
BACKGROUND:This work aimed to screen key biomarkers related sepsis progression by bioinformatics analyses. MATERIAL AND METHODS:The microarray datasets of blood and neutrophils from patients with or septic shock were downloaded Gene Expression Omnibus database. Then, differentially expressed genes (DEGs) 4 groups (sepsis versus normal samples; controls controls) respectively identified followed functional Subsequently, protein–protein network was constructed, sub-modules extracted. Finally,...
Sepsis is a severe systemic infectious disease that often leads to multi-organ dysfunction. One of the common and serious complications sepsis renal injury. In this study, we aimed investigate potential mechanistic role novel compound called H-151 in septic kidney We also examined its impact on function mouse survival rates. Initially, confirmed abnormal activation STING-TBK1 signaling pathway kidneys mice. Subsequently, treated mice with observed significant improvement sepsis-induced This...
Abstract Aims To determine the contributions of different kinds symptoms to quality life and mediating effect psychological physical between heart failure life. Design A multi‐centre cross‐sectional study. Methods 2006 chronic patients from four cities were recruited in China January 2021 December 2022. Patients' self‐reported, data analysed using correlation analysis, dominance analysis effects analysis. Results The revealed that overall mean failure, .083, .085 .111; 29.5%, 30.2% 39.5%...
Histones are considered potential risk factors that contribute to the development of septic acute kidney injury (SAKI) by inducing apoptosis and inflammation. This study aimed explore protective effects heparin on through neutralization extracellular histones (EH) uncover underlying mechanism. C57BL mice (16 each) were randomly divided into sham group, sepsis group (established cecal ligation puncture operation, CLP), intervention group. Mice in received a subcutaneous injection...