A5076789533- Immune Response and Inflammation
- Sepsis Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Inflammation biomarkers and pathways
- Respiratory Support and Mechanisms
- Renal and related cancers
- Cardiac Ischemia and Reperfusion
- Telomeres, Telomerase, and Senescence
- Diet and metabolism studies
- Pancreatitis Pathology and Treatment
- Acute Kidney Injury Research
- interferon and immune responses
- Neonatal Respiratory Health Research
- Immune Cell Function and Interaction
- Muscle and Compartmental Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetic and Kidney Cyst Diseases
- Diabetes Treatment and Management
- Andrographolide Research and Applications
- Medicinal Plant Pharmacodynamics Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Inflammasome and immune disorders
- MicroRNA in disease regulation
- Adrenal Hormones and Disorders
- Pharmacology and Obesity Treatment
Shandong Provincial QianFoShan Hospital
2025
Shandong First Medical University
2025
Tianjin Medical University General Hospital
2015-2023
University of Iowa
2019-2020
ABSTRACT Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome, remain the leading causes of morbidity mortality in intensive care units. Ulinastatin (UTI), a serine protease inhibitor, possesses anti-inflammatory properties has been suggested to modulate lipopolysaccharide (LPS)-induced sepsis; thus, it is now widely used treatment pancreatitis, sepsis, septic shock. Toll-like receptor 4 (TLR4), an essential LPS signaling receptor, plays critical role activation...
Acute kidney injury (AKI) is a common clinical condition of growing incidence. Patients who suffer severe AKI have higher risk developing interstitial fibrosis, chronic disease, and end-stage renal disease later in life. Cellular senescence persistent cell cycle arrest altered gene expression pattern evoked by multiple stressors. The number senescent cells increases with age even small numbers these can induce inflammation fibrosis; indeed, organs including kidneys, the accumulation such...
Abstract Background Acute renal failure due to crush syndrome is one of the leading causes death in disasters. Ischemic Postconditioning (IPC) a potentially effective strategy protect against ischemic reperfusion injury, but few studies noted its protective effect induced acute kidney injury (AKI). Hence, this study investigated optimal IPC prevent AKI and reveal related cellular mechanisms. Methods The right lower extremities rabbits were constantly compressed for 8 h then performed five...
Histones are considered potential risk factors that contribute to the development of septic acute kidney injury (SAKI) by inducing apoptosis and inflammation. This study aimed explore protective effects heparin on through neutralization extracellular histones (EH) uncover underlying mechanism. C57BL mice (16 each) were randomly divided into sham group, sepsis group (established cecal ligation puncture operation, CLP), intervention group. Mice in received a subcutaneous injection...
Purpose: Intra-abdominal infection is a complex pathophysiological process involving multiple systems and organs of the body. Abdominal infections complicated by severe sepsis or septic shock have high mortality rate 30– 50%. Therefore, novel strategies to treat are urgently needed. Methods: Andrographolide (AD), main active ingredient Andrographis paniculata , reportedly exerts beneficial effects on mice with sepsis. However, its exact mechanism action in attenuating inflammation due...
Patients with acute respiratory distress syndrome supported veno-venous extracorporeal membrane oxygenation benefit from higher positive end-expiratory pressure combined conventional ventilation during the early period. The role of incremental titration in patients severe remains unclear. This study aimed to determine preferred method for setting on support.We retrospectively reviewed all subjects 2009 2019 intensive care units Tianjin Third Central Hospital. Subjects were divided into two...
Objective To investigate the effect of ulinastatin on apoptosis regulatory T cells (Tregs) and cytokine secretion in septic mice. Methods A total 60 male mice were randomized into sham group, model group 20 each group. The sepsis was reproduced by cecal ligation perforation, received celiotomy without puncture, given 100 000 U/kg tail intravenous injection at 30 min after operation. rates detected flow cytometry, level interleukin-2 (IL-2), IL-4 interferon γ determined enzyme-linked...