A5101569692- Neuroscience and Neuropharmacology Research
- Esophageal and GI Pathology
- Pain Mechanisms and Treatments
- Bacterial Infections and Vaccines
- Gastric Cancer Management and Outcomes
- Memory and Neural Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Esophageal Cancer Research and Treatment
- Neurotransmitter Receptor Influence on Behavior
- Cardiovascular Function and Risk Factors
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- Heart Rate Variability and Autonomic Control
- Neurological Disease Mechanisms and Treatments
- Gastroesophageal reflux and treatments
- Neuropeptides and Animal Physiology
- Cytomegalovirus and herpesvirus research
- Axon Guidance and Neuronal Signaling
- Ion channel regulation and function
- Cardiovascular Effects of Exercise
- Inflammation biomarkers and pathways
- Insect and Pesticide Research
- User Authentication and Security Systems
- Synthesis of Tetrazole Derivatives
- Cancer, Stress, Anesthesia, and Immune Response
Allegheny Health Network
2025
Ningxia Medical University
2023
Fudan University
2014-2021
State Key Laboratory of Medical Neurobiology
2005-2020
Shanghai First People's Hospital
2020
Huazhong University of Science and Technology
2009-2019
Capital Institute of Pediatrics
2019
Creative Commons
2019
Tongji Hospital
2017-2019
Zhongshan Hospital
2018-2019
Abstract Enhancer of zeste homolog 2 (EZH2), a methyltransferase that di- and tri-methylates lysine-27 histone H3, largely functions as transcriptional repressor, plays critical role in various kinds cancers. Here we report novel function EZH2 regulating autophagic cell death (ACD) vascular smooth muscle cells (VSMCs) affect aortic dissection (AD). Inhibition activity by UNC1999 or knockdown resulted VSMC loss, while overexpression facilitated growth, these effects on VSMCs were independent...
Tissue plasminogen activator (tPA) is approved for treatment of acute ischemic stroke, but it increases the risk cerebral hemorrhage. Accumulating evidence suggests that von Willebrand factor (VWF) plays a pivotal role in thrombus formation and microcirculatory disturbances after stroke. By cleaving VWF, ADAMTS13 (a disintegrin metalloproteinase with thrombospondin type 1 motif, member 13) protects mice from Therefore, we hypothesized recombinant (rADAMTS13) could increase safety tPA...
Objective: To assess the impact of socioeconomic and other factors on progression from gastroesophageal reflux disease (GERD) Barrett’s esophagus (BE) to esophageal adenocarcinoma (EAC). Summary Background Data: Socioeconomic status (SES) influences outcomes in EAC, but its role GERD BE EAC is not well-defined. Risk may be influenced by access engagement with endoscopic screening surveillance, healthcare utilization, health literacy competing social determinants that vary SES. Methods:...
Itch is an unpleasant sensation that initiates scratching behavior. The itch–scratch reaction a complex phenomenon implicates supraspinal structures required for regulation of sensory, emotional, cognitive, and motivational aspects. However, the central mechanisms underlying processing itch interplay regions spinal cord in regulating processes are poorly understood. Here, we have shown neural projections from anterior cingulate cortex (ACC) to dorsal medial striatum (DMS) constitute critical...
An important reasons for drug relapse is the retrieval of withdrawal memory induced by conditioned context. Previous studies have suggested that basolateral amygdala (BLA) plays an role in context-induced morphine memory. However, downstream neuronal circuits activation BLA remain unknown. Using retrograde labeling, immunohistochemical, and optogenetic approaches, we found that, although neurons projecting to prelimbic cortex (PrL) played memory, they do not exhibit increased expression...
Since progressive intracranial haemorrhage (PIH) was introduced in neurosurgical literatures, several studies have been performed. PIH has shown to be associated with a high increase the risk of clinical worsening and related morbidity mortality as well. So, early detection prediction is practically important situation.To investigate factors patients acute traumatic brain injury (TBI) analyse their significances.PIH confirmed by comparing first repeated CT scans. Data compared included...
Abstract Adult hippocampal neurogenesis is crucial for preserving normal brain function, but how it regulated by niche cells uncertain. Here we show that β-arrestin 1 (β-arr1) in dentate gyrus (DG) regulates neural precursor proliferation. β-arr1 knockout (KO) mice reduced proliferation subgranular zone (SGZ) which could be rescued selective viral expression of not its nuclear-function-deficient mutants under control hGFAP promotor DG. Compared with wild type astrocytes, KO astrocytes...
In palmprint recognition, researchers can extract ridges, singular points and minutia as features from high resolution images while in low they generally principal lines, wrinkles texture. And now almost all research concentrates on for civil commercial applications. This is also the focus of this paper. paper, a new method based 2D hybrid Log-Gabor filter, D-S evidence theory ANOVA (Analysis Of Variance) proposed feature extraction. images, filter constructed by number weighted filters with...
Abstract Recently, we found that morphine promoted presynaptic glutamate release of dopamine (DA) neurons in the ventral tegmental area (VTA), which constituted main mechanism for morphine-induced increase VTA-DA neuron firing and related behaviors (Chen et al., 2015). However, what source DA VTA is by remains unknown. To address this question, used optogenetic strategy to selectively activate glutamatergic inputs from different projection then observed effect on them. The result shows...
To the Editor: Mycoplasma pneumoniae is a common pathogen that leads to respiratory tract infections in children, often causing immune-related injuries multiple other organs and tissues. The involvement of central nervous system has been reported 5% 7% patients with M. infection.[1] clinical manifestations encephalitis are highly heterogeneous, more than half experience seizures during acute phase, status epilepticus occurring severe cases.[2] Status yet critical illness children. Although...
The PI3K/Akt signal transduction pathway plays an important role in pre-implantation embryonic development. tumor suppressor gene PTEN negatively regulates the pathway. Although PI3K is constitutively activated during development, currently no evidence shows presence and possible involvement of early embryo We investigated expression protein germinal vesicle (GV) stage oocytes as well embryos. form was distributed peripheral GV compact morula. Treatment with inhibitor bpV(pic) did not affect...