A5063479269- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Cardiac Valve Diseases and Treatments
- RNA modifications and cancer
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Congenital Heart Disease Studies
- Autophagy in Disease and Therapy
- Climate Change and Health Impacts
- Birth, Development, and Health
- Vasculitis and related conditions
- Vascular Procedures and Complications
- Psoriasis: Treatment and Pathogenesis
- Histone Deacetylase Inhibitors Research
- Pregnancy and preeclampsia studies
- Ferroptosis and cancer prognosis
- Systemic Lupus Erythematosus Research
- interferon and immune responses
- Immune cells in cancer
- Congenital heart defects research
- Adrenal and Paraganglionic Tumors
- Cerebrovascular and Carotid Artery Diseases
- Pharmacy and Medical Practices
- Macrophage Migration Inhibitory Factor
- Pituitary Gland Disorders and Treatments
First Affiliated Hospital of Anhui Medical University
2024
Anhui Medical University
2024
Second Military Medical University
2008-2024
Huazhong University of Science and Technology
2015-2023
Tongji Hospital
2015-2023
Shenzhen Children's Hospital
2023
Changhai Hospital
2008-2016
Peking University
2011
Jiangxi Provincial People's Hospital
2010
Chinese People's Liberation Army
2008
Smooth muscle cell (SMC) loss is the characteristic feature in pathogenesis of aortic dissection (AD), and ferroptosis a novel iron-dependent regulated death driven by excessive lipid peroxidation accumulation. However, whether targeting an effective approach for SMC AD treatment remains unclear. Here, we found that iron level, ferroptosis-related molecules TFR, HOMX1, ferritin product 4-hydroxynonenal were increased aorta AD. Then, screened several inhibitors histone methyltransferases...
Abstract Background E1A-associated 300-kDa protein (P300), an endogenous histone acetyltransferase, contributes to modifications of the chromatin landscape genes involved in multiple cardiovascular diseases. Ferroptosis vascular smooth muscle cells (VSMCs) is a novel pathological mechanism aortic dissection. However, whether P300 regulates VSMC ferroptosis remains unknown. Methods Cystine deprivation (CD) and imidazole ketone erastin (IKE) were used induce ferroptosis. Two different...
Abstract Enhancer of zeste homolog 2 (EZH2), a methyltransferase that di- and tri-methylates lysine-27 histone H3, largely functions as transcriptional repressor, plays critical role in various kinds cancers. Here we report novel function EZH2 regulating autophagic cell death (ACD) vascular smooth muscle cells (VSMCs) affect aortic dissection (AD). Inhibition activity by UNC1999 or knockdown resulted VSMC loss, while overexpression facilitated growth, these effects on VSMCs were independent...
Prevention of neointima formation is the key to improving long-term outcomes after stenting or coronary artery bypass grafting. RNA N6 -methyladenosine (m6 A) methylation has been reported be involved in development various cardiovascular diseases, but whether it a regulatory effect on unknown. Herein, we revealed that methyltransferase-like 3 (METTL3), major methyltransferase m6 A methylation, was downregulated during vascular smooth muscle cell (VSMC) proliferation and formation. Knockdown...
Abstract Background Gallstones, a global hepatobiliary disorder, are linked to systemic inflammation, lipid disturbances, and metabolic-associated fatty liver disease (MAFLD). This population-based study aims investigate the association of novel inflammation-lipid composite biomarker high-sensitivity C-reactive protein-to-HDL cholesterol ratio (CHR) with gallstones evaluate whether MAFLD mediates this relationship. Methods cross-sectional analysis utilized data from National Health Nutrition...
The purpose of the study was to examine association between white blood cell count (WBCc) on admission and early outcome in patients with acute Stanford type A aortic dissection (TAAD).From January 2012 December 2018, we retrospectively evaluated a series 331 consecutive underwent surgery for TAAD Tongji Hospital. were divided into 2 groups based WBCc, i.e. normal WBCc group (WBCc≤11 × 109/L) leukocytosis (WBCc> 11 109/L). perioperative data compared groups. in-hospital mortality compositive...
Abstract Background Vascular smooth muscle cell (VSMC) phenotype switching is critical for neointima formation, which the major cause of restenosis after stenting or coronary artery bypass grafting. However, epigenetic mechanisms regulating VSMCs, especially histone methylation, are not well understood. As a main component lysine demethylases, Jumonji demethylases might be involved in VSMC and formation. Methods results A mouse carotid injury model proliferation were constructed to...
Our goal was to compare the performance of frozen elephant trunk (FET) and hybrid aortic arch debranching procedures for acute Type I dissection.From January 2013 December 2015, 168 patients with disease underwent ascending aorta total replacement FET implantation (the group, n = 132) or 1-stage exclusion using an endovascular stent in a retrograde manner 36). A propensity score-matched subgroup 26 pairs identified. Perioperative data mid-term follow-up results were assessed.In groups,...
Background The association between ambient temperature and cardiovascular diseases has been well established, but evidence of temporal changes in the risk acute aortic dissection (AAD) onset is lacking. Methods Results We conducted an 8-year time-series study based on data from 2120 patients diagnosed with AAD at Tongji Hospital (Wuhan, China). Daily meteorological parameters were measured area. Spearman's rank correlation analysis was applied to measure associations daily air pollution...
Filamins (FLNs) are actin cross-linking proteins, and as scaffolding FLNs closely associated with the stabilization of cytoskeleton. Nevertheless, biological importance in aortic dissection (AD) has not been well-elucidated. In this study, we first reanalyzed datasets downloaded from Gene Expression Omnibus (GEO) database, found that addition to extracellular matrix, cytoskeleton is a key structure AD. Given involved remodeling affect cellular functions, measured their expression levels...
Background Acute aortic dissection (AAD) is a life-threatening emergency with poor clinical outcomes. Understanding the chronological patterns of AAD onset would be helpful for identifying triggers and preventing this catastrophic event. Methods We collected data from 2048 patients diagnosed at Tongji Hospital (Wuhan, China) 2011 to 2018. The χ 2 test was used determine whether specific period had significantly different seasonal/weekly distributions other periods. Fourier models were...
Thoracic aortic aneurysm (TAA) is a life-threatening cardiovascular disease whose formation reported to be associated with massive vascular inflammatory responses. To elucidate the roles of immune cell infiltration in pathogenesis underlying TAA, we utilized multiple TAA datasets (microarray data and scRNA-seq data) various immune-related algorithms (ssGSEA, CIBERSORT, Seurat) reveal landscapes microenvironment TAA. The results exhibited significant increase macrophages T cells, which were...
Background: Lysyl oxidases (LOXs), including LOX, LOXL1, LOXL2, LOXL3, and LOXL4, catalyze the formation of a cross-link between elastin (ELN) collagen. Multiple LOX mutations have been shown to be associated with occurrence aortic dissection (AD) in humans, LOX-knockout mice died during perinatal period due aneurysm rupture. However, expression levels roles other members AD remain unknown. Methods: A total 33 aorta samples 15 normal were collected for LOXs mRNA protein detection. We also...
Coronary restenosis is an important cause of poor long-term prognosis in patients with coronary heart disease. Here, we show that lysine methyltransferase SMYD2 expression the nucleus significantly elevated serum- and PDGF-BB-induced vascular smooth muscle cells (VSMCs), tissues carotid artery injury-induced neointimal hyperplasia. Smyd2 overexpression VSMCs (Smyd2-vTg) facilitates, but treatment its specific inhibitor LLY-507 or knockdown inhibits VSMC phenotypic switching neointima...
The purpose of this study is to report the efficacy transbrachial and femoral artery approach endovascular therapy with catheter-directed thrombolysis (CDT) adjunctive for flush infrarenal aortic occlusion (FIAO).From March 2012 December 2013, 11 consecutive patients (9 males; mean age 68 years; range 54-80 years) were submitted FIAO. All treated CDT initially then treatments performed correct underlying lesions.Complete reconstruction occluded aortoiliac arteries was successfully achieved...
The optimal hypothermic level during circulatory arrest is controversial. aim of our study was to comprehensively assess the impact moderate with antegrade cerebral perfusion (ACP) on total aortic arch replacement.From 2010 2013, data were collected from 99 consecutive patients acute type A dissection. All underwent replacement plus frozen elephant trunk procedure. There 51 in deep hypothermia (DHCA) group and 47 (MHCA) group. Either unilateral or bilateral ACP applied for protection....
Objective: To detect the potential risk factors associated with early mortality in patients who received extensive surgical management, form of total arch replacement plus frozen elephant trunk and debranching (hybrid repair technique), for acute type A aortic dissection.Methods: The clinical data 452 surgically treated dissection at our center, between March 2010 December 2016, have been retrieved.Uni multivariate logistic regression analyses were carried out to effect various preoperative...
Background. The misdiagnosis of aortic dissection (AD) can lead to a catastrophic prognosis. There is currently lack stable serological indicators with excellent efficacy for the differential diagnosis AD and coronary artery disease (CAD). A recent study has shown an association between iron metabolism. Thus, we investigated whether metabolism could discriminate from CAD. Methods. This retrospective multicenter cross-sectional biomarkers AD. We collected metabolism, liver function, kidney...
Abdominal aortic aneurysm (AAA) is characterized by abdominal aorta dilatation and progressive structural impairment usually an asymptomatic potentially lethal disease with a risk of rupture. To investigate the underlying mechanisms AAA initiation progression, seven datasets related to human mice were downloaded from GEO database reanalysed in present study. After comprehensive bioinformatics analysis, we identified enriched pathways associated inflammation responses, vascular smooth muscle...
The optimal treatment of intramural hematoma (IMH) involving the ascending aorta remains controversial. This study aimed to analyze results management patients with acute IMH and extending into descending thoracic aorta, compare outcomes endovascular aortic repair (TEVAR) that medical therapy (MT), assess risk factors associated adverse events.We retrospectively analyzed all diagnosed from January 2012 December 2019. primary end points during follow-up were disease-related death...