A5101499082- Lymphoma Diagnosis and Treatment
- Blood Pressure and Hypertension Studies
- Viral-associated cancers and disorders
- Cardiovascular Function and Risk Factors
- Acute Myocardial Infarction Research
- Cardiovascular Health and Disease Prevention
- Cancer-related molecular mechanisms research
- Lipid metabolism and disorders
- Cerebrovascular and Carotid Artery Diseases
- Pulmonary Hypertension Research and Treatments
- Cardiac Imaging and Diagnostics
- Heart Failure Treatment and Management
- Circular RNAs in diseases
- Cardiovascular Effects of Exercise
- Cardiac pacing and defibrillation studies
- Venous Thromboembolism Diagnosis and Management
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Coronary Interventions and Diagnostics
- Cardiac electrophysiology and arrhythmias
- CNS Lymphoma Diagnosis and Treatment
- RNA modifications and cancer
- Antiplatelet Therapy and Cardiovascular Diseases
- Cutaneous lymphoproliferative disorders research
- Heart Rate Variability and Autonomic Control
Guiyang Medical University
2018-2024
Guizhou Cancer Hospital
2015-2024
Affiliated Hospital of Guizhou Medical University
2018-2024
Ningbo University
2017-2024
Fudan University
2022-2024
Microsoft (United States)
2024
Sun Yat-sen University
2021-2023
Xi'an Chest Hospital
2023
The First People's Hospital of Changde
2023
Central South University
2023
Background/Aims: MicroRNAs (miRNAs) can be used as biomarkers for cardiovascular diseases, especially heart failure. However, there are few reports on serum exosomal miRNA in patients with acute failure (AHF) due to Dilated cardiomyopathy (DCM). Methods: We analyzed 3 different miRNAs (exo-miR-92b-5p, exo-miR-192-5p, and exo-miR-320a) 43 DCM-AHF 34 healthy volunteers a control group (CG) by using exosome separation followed quantitative reverse-transcript PCR assay. Exosomes were identified...
The long-term survival benefit for radiotherapy (RT) in early-stage extranodal natural killer/T-cell lymphoma (NKTCL) is not known, and it unclear whether improved locoregional control (LRC) translates into a benefit.To investigate the dose-dependent effect potential benefits of RT on basis LRC improvements.Review clinical data patients with NKTCL at 10 institutions China between 2000 2014. Radiotherapy dose as continuous variable was entered Cox regression model by using penalized spline to...
An eight weeks feeding trial was conducted to investigate the effects of dietary lipid levels on growth performance, metabolism and immune response Japanese seabass (Lateolabrax japonicus). Five diets were formulated with gradient (79.6, 104.4, 129.1, 154.9 178.6 g kg−1). Results revealed that feed utilization fish significantly lower in group L178.6 than other groups (p < 0.05). Lipid accumulation whole body, muscle intraperitoneal increased increasing levels. The mRNA adipose triglyceride...
Background: Circulating microRNA (miRNA) biomarkers have been extensively reported in cardiovascular diseases (CVDs). However, serum exosomal miRNA (exo-miRNA) as biomarker patients with heart failure (HF) reduced ejection fraction (HFrEF) remain largely unexplored. We sought to investigate the potential of three types exo-miRNAs for diagnosis HFrEF who were admitted hospital because acute (AHF). Methods: A total 28 hospitalized AHF, including de novo AHF and decompensated HF, 30 volunteers...
Sacubitril-valsartan has been shown to have superior effects over angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in patients with heart failure (HF) hypertension. The efficacy safety of sacubitril-valsartan HF are controversial. We performed a meta-analysis randomized controlled trials assess compare the effect adverse events sacubitril-valsartan, valsartan, enalapril HF.We conducted systematic search using PubMed, Embase, Cochrane Library, ClinicalTrials.gov....
Radiofrequency ablation is used as a first-line therapy for accessory pathways (APs). However, data regarding the effects of pulsed field (PFA) on APs are limited. We sought to evaluate acute procedural and 6-month success safety PFA in cohort patients with APs.
Abstract Antiphospholipid syndrome (APS) is an acquired thrombophilia with uncertain role in the development of chronic thromboembolic pulmonary hypertension (CTEPH). We aimed to assess association APS clinical phenotype CTEPH. retrospectively reviewed data CTEPH patients referred our center. Clinical, angiographic, and hemodynamic were available for all patients. was diagnosed presence one or more positive antiphospholipid (aPL) tests confirmed than 12 weeks apart. Data compared between...
Abstract This study aimed to predict the 5‐year overall survival (OS) benefit of pola‐R‐CHP versus R‐CHOP in POLARIX trial based on 2‐year event‐free (EFS) and progression‐free (PFS) rates diffuse large B‐cell lymphoma (DLBCL). We identified randomized controlled trials (RCT) published before 31 May 2023. The correlation between logarithmic (log) hazard ratio (HR) for EFS (HR ) or PFS HR OS was estimated at trial‐level. Correlation analysis performed treatment arm‐level. Linear regression...
<h3>Background</h3> Increased oxidative stress and vascular inflammation have been demonstrated in patients with cardiac syndrome X (CSX). Bilirubin, once considered simply the metabolic end product of haem degradation, has emerged as a potential endogenous inhibitor atherosclerosis. This study was conducted to evaluate prognostic role serum bilirubin disease progression clinical outcome CSX. <h3>Methods</h3> A total 108 consecutive CSX were enrolled. Serum levels examined from blood samples...
Nonalcoholic fatty liver disease (NAFLD) is a metabolic mainly on account of hypercholesterolemia and may progress to cirrhosis hepatocellular carcinoma. The discovery effective therapy for NAFLD an essential unmet need. Angiopoietin-like protein 3 (ANGPTL3), critical lipid metabolism regulator, resulted in increased blood lipids was elevated NAFLD. Here, we developed nanobody-heavy chain antibody (VHH-Fc) inhibit ANGPTL3 treatment.In this study, retrieved anti-ANGPTL3 VHH Fc fusion protein,...
Objectives Endothelial dysfunction plays a key role in the pathogenesis of cardiovascular disease. However, gender-related differences risk factors for endothelial are controversial. We investigated gender factor profiles Chinese hypertensive patients. Methods Vascular functions 213 patients were measured by digital reactive hyperemia peripheral arterial tonometry (RH-PAT). Peripheral blood samples collected, and self-reported smoking alcohol consumption status, age, body mass index, heart...
The prevalence and distribution of congenital thrombophilia is still unclear in patients with pulmonary embolism (PE). We aimed to determine the clinical characteristics PE their subsequent outcomes. A prospective observational study was conducted from May 2013 June 2018. total 436 consecutive were enrolled. All tested for protein C, S, antithrombin III (ATIII), factor V Leiden, prothrombin G20210A mutations. median follow-up duration ∼800 days (range, 11-1872 days). Congenital diagnosed 31...
The role of congenital thrombophilia in chronic thromboembolic pulmonary hypertension (CTEPH) remains unresolved.The purpose this study was to investigate the prevalence, genetic background, and clinical phenotype CTEPH.In total, 367 patients with CTEPH from May 2013 December 2020 were consecutively enrolled cross-sectional FuWai Hospital Peking Union Medical College China. primary outcome occurrence diagnosed through tests for anticoagulants activity (including protein C, S, antithrombin...
The aim of this study was to determine the impact analyzing age as a continuous variable on survival outcomes and treatment selection for extranodal nasal-type NK/T-cell lymphoma.The risk mortality increased with increasing age, without an apparent cutoff point. Patients' variable, independently associated overall after adjustment covariates. Older early-stage patients were more likely receive radiotherapy only whereas young-adult advanced-stage tended non-anthracycline-based chemotherapy. A...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Atherosclerosis (AS) ultimately cause major adverse cardiovascular events (MACEs). While traditional strategies by lipid-reducing have reduced MACEs, many patients continue to face significant risks. It might attribute the upregulation of CD47 expression in AS lesions, that mediated anti-efferocytosis macrophages. Therefore, we propose simultaneously blocking ANGPTL3, a vital regulator lipid metabolism, and be potential approach for therapy. Firstly, investigate role novel anti-ANGPTL3...
Abstract BACKGROUND The association between impaired renal function and increase left ventricular mass was shown to be related in arterial stiffness, which indicates that vascular homeostasis remodeling may impact the hypertrophy (LVH) patients with dysfunction. METHODS We measured peripheral reactive hyperemia index (RHI) estimated glomerular filtration rate (eGFR) 317 hypertensive comprising 115 normal RHI (RHI &gt; 1.67) eGFR (eGFR ≥ 90ml/min per 1.73 m 2 ), 136 low ≤ 1.67), 27 (60...