A5069867382- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Cervical and Thoracic Myelopathy
- Anesthesia and Pain Management
- Cardiovascular Effects of Exercise
- Medical Imaging and Analysis
- Cardiovascular Function and Risk Factors
- Pituitary Gland Disorders and Treatments
- Cancer, Hypoxia, and Metabolism
- Abdominal Trauma and Injuries
- Emergency and Acute Care Studies
- Trauma and Emergency Care Studies
- Inflammatory Bowel Disease
- Cerebrospinal fluid and hydrocephalus
- Microbial Metabolism and Applications
- Extracellular vesicles in disease
- Opioid Use Disorder Treatment
- Lipoproteins and Cardiovascular Health
- Aldose Reductase and Taurine
- Anatomy and Medical Technology
- Heat shock proteins research
- Glutathione Transferases and Polymorphisms
- Appendicitis Diagnosis and Management
- NF-κB Signaling Pathways
- Glioma Diagnosis and Treatment
Emory University
2013-2021
Shanxi Medical University
2020
Neurological Surgery
2014-2019
University of California, Davis
2013-2019
Shanghai Jiao Tong University
2018
Shanghai Ninth People's Hospital
2018
Ningbo University
2018
Xuzhou Medical College
2017
The First People’s Hospital of Lianyungang
2017
Spine Institute of Louisiana
2014-2016
Background/Aims: MicroRNAs (miRNAs) can be used as biomarkers for cardiovascular diseases, especially heart failure. However, there are few reports on serum exosomal miRNA in patients with acute failure (AHF) due to Dilated cardiomyopathy (DCM). Methods: We analyzed 3 different miRNAs (exo-miR-92b-5p, exo-miR-192-5p, and exo-miR-320a) 43 DCM-AHF 34 healthy volunteers a control group (CG) by using exosome separation followed quantitative reverse-transcript PCR assay. Exosomes were identified...
Cervical total disc replacement (CTDR) was developed to treat cervical spondylosis, while preserving motion. While anterior discectomy and fusion (ACDF) has been the standard of care for 2-level disease, a randomized clinical trial (RCT) suggested similar outcomes. Cost-effectiveness this intervention never elucidated.To determine cost-effectiveness CTDR compared with ACDF.Data were derived from an RCT that followed up 330 patients over 24 months. The original consisted multi-institutional...
Summary Interferon‐based standard of care treatments ( SOC ) for chronic hepatitis C are unable to provide high cure rates in certain subgroups the infected population and can cause debilitating side effects. Clinical trials evaluating all‐oral, interferon‐free have demonstrated sustained virologic response with no resistance or major adverse events most populations. As these drug regimens move towards FDA approval, it will be important assess their cost‐effectiveness addition clinical...
Background: Circulating microRNA (miRNA) biomarkers have been extensively reported in cardiovascular diseases (CVDs). However, serum exosomal miRNA (exo-miRNA) as biomarker patients with heart failure (HF) reduced ejection fraction (HFrEF) remain largely unexplored. We sought to investigate the potential of three types exo-miRNAs for diagnosis HFrEF who were admitted hospital because acute (AHF). Methods: A total 28 hospitalized AHF, including de novo AHF and decompensated HF, 30 volunteers...
BACKGROUND: The cervical total disc replacement (cTDR) was developed to treat degenerative disease while preserving motion. OBJECTIVE: Cost-effectiveness of this intervention established by looking at 2-year follow-up, and update reevaluates our analysis over 5 years. METHODS: Data were derived from a randomized trial 330 patients. the 12-Item Short Form Health Survey transformed into utilities using SF-6D algorithm. Costs calculated extracting diagnosis-related group codes then applying...
Objectives: We assessed the impact of antihypertensive medication (AHM) adherence on incidence and associated Medicaid costs acute cardiovascular disease (CVD) events among beneficiaries. Methods: The study cohort (n=59,037) consists nonelderly adults continuously enrolled (36 mo above) in a fee-for-service program. AHM was calculated using possession ratio (MPR) stratified to low (MPR<60%), moderate (60%≤MPR<80%), high (MPR≥80%) levels. used proportional hazard model estimate risk for...
A potential long-term complication of lumbar fusion is the development adjacent segment disease (ASD), which may require surgical intervention and adversely affect outcomes. high incidence recurrent ASD was reported in patients who underwent second (repeat) PLIF for symptomatic ASD. Herein, a feasible method, oblique interbody combined with transforaminal endoscopic discectomy (OLIF-TELD) dealing disc herniation upward or downward migration after spinal fusion, proposed.A total 19 revision...
Recently a clinical decision rule (CDR) to identify children at very low risk for intraabdominal injury needing acute intervention (IAI) following blunt torso trauma was developed. Potential benefits of CDR include more appropriate abdominal computed tomography (CT) use and decreased hospital costs. The objective this study compare the cost-effectiveness implementing compared usual care evaluation with trauma. hypothesis that care, implementation would result in lower CT costs.A analytic...
Cost-utility analysis of an annular closure device (ACD) based on data from a prospective, multicenter randomized controlled trial (RCT) OBJECTIVE.: The aim this study was to determine the cost-effectiveness novel ACD in patient population at high risk for recurrent herniation following discectomy.Lumbar disc patients with defect widths ≥6 mm are limited discectomy. Recurrent is associated worse clinical outcomes and greater healthcare costs. A may reduce incidence burdens.A decision...
In Brief Study Design. Decision analysis from prior randomized controlled trial (RCT) data. Objective. To describe the importance of developing baseline utility indices while identifying effective treatment options for cervical spine disease. Summary Background Data. Cervical total disc replacement (CTDR) was developed to treat spondylosis preserving motion. Although anterior discectomy and fusion (ACDF) has been standard care, a recent RCT suggested similar outcomes 2-level The...
Background: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is associated with increased atherosclerotic cardiovascular disease (ASCVD) risk, which relatively unique in its high specificity for vascular inflammation.So we study if Lp-PLA2 independent of or complementary to cardiac troponin I (cTn I) as a risk predictor acute myocardial infarction (AMI).Methods: Across-sectional analysis on 125 patients admitted the department chest pain, including age, gender, family history, smoking...
INTRODUCTION: Cervical total disc replacement (TDR) was developed to treat neck pain and neurological sequelae associated with cervical spondylosis, while preserving motion. While ACDF has been the standard of care, a recent randomized controlled trial (RCT) 1 suggested similar outcomes for 2-level disease. However, quality life benefit in this population, afforded by both TDR ACDF, never fully elucidated. The purpose our investigation better define changes utility perceived value patients...