A5074124766- Liver Disease Diagnosis and Treatment
- Skin and Cellular Biology Research
- Liver Disease and Transplantation
- Diet, Metabolism, and Disease
- Hepatitis C virus research
- Alcohol Consumption and Health Effects
- Inflammatory Bowel Disease
- Pancreatitis Pathology and Treatment
- Hepatitis B Virus Studies
- Hair Growth and Disorders
- Helicobacter pylori-related gastroenterology studies
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Epigenetics and DNA Methylation
- Gastric Cancer Management and Outcomes
- Eosinophilic Esophagitis
- Airway Management and Intubation Techniques
- Esophageal and GI Pathology
- Foreign Body Medical Cases
- Silk-based biomaterials and applications
- Wnt/β-catenin signaling in development and cancer
- Porphyrin Metabolism and Disorders
- Gastrointestinal Tumor Research and Treatment
- Diet and metabolism studies
- Cardiovascular Disease and Adiposity
The First Affiliated Hospital, Sun Yat-sen University
2013-2025
Sun Yat-sen University
2013-2025
University Gastroenterology
2022
Stanford University
2003-2009
University of Michigan
2009
VA Palo Alto Health Care System
2003-2004
The liver effect of orlistat as a weight control treatment in patients with nonalcoholic fatty disease (NAFLD) obesity remains undetermined. This study quantified fat improvement by Chinese cohort NAFLD accompanied obesity, diagnosed lower body mass index threshold than that for White patients.We conducted parallel-group, open-label, 24-week, randomized clinical trial registered at the Clinical Trial Registry (ChiCTR-IPR-17012258). Obese participants were 1:1.5 to intervention group or...
The recent FDA-approval of resmetirom for treating metabolic dysfunction-associated steatohepatitis (MASH) in patients necessitates patient selection significant fibrosis or higher (≥F2). No existing vibration-controlled transient elastography (VCTE) algorithm targets ≥F2. ALADDIN study addressed this gap by introducing a machine-learning-based web calculator that estimates the likelihood using routine laboratory parameters with and without VCTE. Our included Training set 827 patients,...
Cancer progression is characterized by extensive tumor invasion into the surrounding extracellular matrix (ECM) and migration to metastatic sites. The increased proteolytic degradation of ECM during directly dependent on activity metalloproteinases (MMPs), counter-balanced tissue inhibitors (TIMPs). In this study, we found that unbalanced expression MMP/TIMP axis genes in tumors was correlated with aberrant epigenotypes various gene promoters. malignant could be therapeutically corrected a...
Keratins (K) 8 and 18 variants predispose carriers to the development of end-stage liver disease patients with chronic hepatitis C progression. Hepatocytes express K8/K18, whereas biliary epithelia K8/K18/K19. K8-null mice, which are predisposed injury, spontaneously develop anti-mitochondrial antibodies (AMA) have altered hepatocyte mitochondrial size function. There is no known association K19 human K8/K18/K19 autoimmune disease. We tested hypothesis that associate primary cirrhosis (PBC),...
Ingestion of foreign bodies (FBs) in the upper esophagus is common South China. It difficult to manage because limited working space and inadequate visual field this area. This randomized, controlled study aimed evaluate usefulness a transparent cap endoscopic management FBs esophagus.Adult patients suspected based on history ingestion, symptoms, barium contrast examination were screened for between March 1, 2009 December 31, 2010. Seventy with endoscopic-confirmed recruited randomly...
The CD4(+) T-cell subgroups play central pathophysiological roles in Crohn's disease (CD); however, their clinical relevance requires additional clarification and remains controversial. We investigated balance Chinese CD patients explored significance.Peripheral blood mononuclear cells serum were collected from 46 23 healthy donors. Circulating Treg, Th1, Th2, Th17 flow cytometrically analyzed. Subgroup-restricted transcription factor expression was determined by real-time polymerase chain...
Background: The clinical burden and natural history of non-alcoholic fatty liver disease (NAFLD) vary globally. We aimed to investigate NAFLD-related mortality profiles in hospitalized patients southern China. Methods: A multicenter retrospective investigation with a 10-year study period (2009–2018) analyzed 10,071 deaths during hospitalization (NAFLD: 2,015; other diseases: 1,140; without 6,916) was performed using multiple cause death analysis. Medical histories biochemistry imaging...
Keratin polypeptides 8 and 18 (K8/K18) are the major intermediate filament proteins of pancreatic acinar cells hepatocytes. Pancreatic keratin function is unknown, whereas hepatocyte keratins protect from mechanical non-mechanical forms stress. We characterized steady-state expression in Balb/c mice after caerulein choline-deficient ethionine-supplemented diet (CDD), or on exposure to generalized stresses heat water immersion. Keratins were studied at protein, RNA organizational levels....
AIM:To investigate the relationship between Apolipoprotein C3 (APOC3 ) (-455T>C) polymorphism and nonalcoholic fatty liver disease (NAFLD) in Southern Chinese han population. METHODS:In this prospective case-control study, we recruited 300 NAFLD patients healthy controls to a cohort representing population at The First Affiliated Hospital, Sun Yat-sen University, from January December 2012.Polymerase chain reaction-restriction fragment length DNA sequencing were used genotype APOC3 variants....
ABSTRACT Based on 16S rRNA gene PCR, no significant difference was observed in rates of detection Helicobacter species intestinal biopsy specimens from 160 Chinese inflammatory bowel disease (IBD) patients (10%) and 80 controls (6.3%). By using a [ 13 C]urea breath test, the H. pylori infection rate 208 IBD (19.7%) found to be significantly lower than that 416 (48.8%).
Insulin resistance (IR) related metabolic disorders are associated with a worse prognosis of chronic hepatitis B virus (CHB) infection or nonalcoholic fatty liver disease (NAFLD). However, the relationships among CHB, steatosis, IR and factors remain controversial. The study aims to evaluate impact insulin severity on profiles in patients NAFLD coincidence two.We conducted cross-sectional between January 2011 December 2018 that included 2768 consecutive Chinese subjects (healthy controls:...
Keratin transgenic mouse models and the association of human keratin mutations with liver disease highlight importance keratins in protecting from environmental insults, but little is known regarding their function gallbladder. We characterized expression pattern filament organization normal polypeptide-8 (K8)-null, K18-null K19-null gallbladders, examined susceptibility to gallbladder injury induced by a high-fat lithogenic diet (LD) K8-null mice. The major are K8>K19>K18 which become...
Objective To investigate: 1) the demographics and clinical characteristics, 2) findings, 3) safety effectiveness in a cohort of Chinese pediatric patients undergoing colonoscopy. Methods The study participants were consecutive aged ≤14 years old that underwent their first colonoscopy endoscopy center at First Affiliated Hospital, Sun Yat-sen University between Jan. 1, 2001 Dec. 31, 2012. Demographic, clinical, endoscopic, pathological findings collected. Results consisted 322 patients,...
To test the hypothesis that K8/K18 variants predispose humans to non-alcoholic fatty liver disease (NAFLD) progression and its metabolic phenotypes.We selected a total of 373 unrelated adult subjects from our Physical Examination Department, including 200 NAFLD patients 173 controls both genders different ages. Diagnoses were established according ultrasonic signs liver. All tested for population characteristics, lipid profile, tests, as well glucose tests. Genomic DNA was obtained...