A5102918253- Reproductive Health and Contraception
- Treatment of Major Depression
- Cardiovascular Issues in Pregnancy
- Schizophrenia research and treatment
- Electroconvulsive Therapy Studies
- Alcohol Consumption and Health Effects
- Maternal and fetal healthcare
- Liver Disease Diagnosis and Treatment
- Blood Coagulation and Thrombosis Mechanisms
- Acute Myocardial Infarction Research
- Mental Health Treatment and Access
- Obesity, Physical Activity, Diet
- Cardiac Health and Mental Health
- Anesthesia and Sedative Agents
- Renal and Vascular Pathologies
- Systemic Sclerosis and Related Diseases
- Ectopic Pregnancy Diagnosis and Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Irish and British Studies
- Traffic Prediction and Management Techniques
- Microscopic Colitis
- Endoplasmic Reticulum Stress and Disease
- Alzheimer's disease research and treatments
- Health Systems, Economic Evaluations, Quality of Life
- Intensive Care Unit Cognitive Disorders
University of Kansas Medical Center
2024-2025
University Medical Center
2025
University Hospital and Clinics
2025
Addenbrooke's Hospital
2010
University of Southampton
2001-2009
Drug Safety Research Unit
1997-2000
Ninewells Hospital
1999
London School of Hygiene & Tropical Medicine
1999
To explore the reasons behind recent increase in antidepressant prescribing United Kingdom. Design Detailed retrospective analysis of data on general practitioner consultations and prescribing. Data source were obtained from practice research database, which contains linked anonymised records over 3 million patients registered UK. extracted for all new incident cases depression between 1993 2005. Review methods was restricted to 170 practices that contributing full duration study.In total,...
Inflammation plays a part in the etiology of dementia. Whether this is primary pathogenesis, or secondary reaction unclear. We postulate that since systemic infection can provoke enhanced synthesis inflammatory mediators brain, such diseases may promote onset carried out nested case-control study using General Practice Research Database. Cases were patients with incident dementia, and controls without diagnosis. Infectious episodes four years preceding diagnosis counted diagnostic codes,...
Background and Aims: Alcohol-associated hepatitis (AH) poses significant short-term mortality. Existing prognostic models lack precision for 90-day Utilizing artificial intelligence in a global cohort, we sought to derive validate an enhanced model. Approach Results: The Global AlcHep initiative, retrospective study across 23 centers 12 countries, enrolled patients with AH per National Institute Alcohol Abuse Alcoholism criteria. Centers were partitioned into derivation (11 centers, 860...
The recent FDA-approval of resmetirom for treating metabolic dysfunction-associated steatohepatitis (MASH) in patients necessitates patient selection significant fibrosis or higher (≥F2). No existing vibration-controlled transient elastography (VCTE) algorithm targets ≥F2. ALADDIN study addressed this gap by introducing a machine-learning-based web calculator that estimates the likelihood using routine laboratory parameters with and without VCTE. Our included Training set 827 patients,...
Aims To estimate the rates of common adverse events in patients treated with proton pump inhibitors omeprazole, lansoprazole and pantoprazole general practice England. Methods In prescription‐event monitoring cohort studies, data on dispensed prescriptions prescribed by practitioners England soon after each drug was launched were linked to subsequent clinical recorded prescriber. 16 205 omeprazole between June 1989 1990, 17 329 May November 1994, 11 541 December 1996 1997 studied. Results...
Objective —To compare the safety and side-effect profiles of four selective serotonin reuptake inhibitor antidepressants (SSRIs), fluvoxamine, fluoxetine, sertraline paroxetine. Methods —The results from observational cohort studies SSRIs were compared. Each these was conducted by Prescription-Event Monitoring (PEM). The exposure data derived general practitioner (GP) prescriptions confidentially supplied Prescription Pricing Authority (PPA) in England. Outcome obtained questionnaires (green...
<h3>OBJECTIVES</h3> To determine the extent of risk myocardial infarction from cigarette smoking in young women, and to examine relation with other putative factors. <h3>DESIGN</h3> Community based case control study. <h3>SETTING</h3> England, Scotland, Wales. <h3>PATIENTS</h3> Women (n = 448) between 16 44 years old a diagnosis incident 1 October 1993 1995. Controls 1728) were age general practice matched women without infarction. <h3>OUTCOMES MEASURES</h3> Odds ratios for associated...
Aims Some reports have suggested that calcium channel blockers may be associated with an increased incidence of depression or suicide. There is a paucity evidence from large scale studies. The aim this study was to assess rates antagonists using data prescription event monitoring Methods Observational studies on cohorts patients lisinopril, enalapril (ACE inhibitors), nicardipine (type 2 blocker) and diltiazem 3 were conducted, prescription‐event monitoring. Rates in the different drugs rate...
Recent studies have shown that modern (third generation), oral contraceptives (OC) are associated with an increased incidence of venous thromboembolic disease compared to older (second OC. It is not known, however, whether this association also true for arterial thrombosis, in particular myocardial infarction. In fact, it has been suggested third generation OC may even be protective against infarction (MI), second The protocol a multicentre case-control study, involving the whole England and...
Recently published papers have shown a slightly increased risk for venous thromboembolism (VTE) among users of third generation oral contraceptive pills (OC) as compared with second OC. The extra is small (about twofold) and could be explained possibly by biases introduced into the original case–control studies. This paper examines possible role prescribing bias (i.e. that doctors would prescribe OC preferentially to women whom they knew at VTE) referral refer on hospital investigations...
Perceiving and navigating through work zones is challenging under-explored, even with major strides in self-driving research. An important reason the lack of open datasets for developing new algorithms to address this long-tailed scenario. We propose ROADWork dataset learn how recognize, observe analyze drive zones. find that state-of-the-art foundation models perform poorly on With our dataset, we improve upon detecting zone objects (+26.2 AP), while discovering higher precision (+32.5%) at...
Objective —To compare the safety and side-effect profiles of four selective serotonin reuptake inhibitor antidepressants (SSRIs), fluvoxamine, fluoxetine, sertraline paroxetine. Methods —The results from observational cohort studies SSRIs were compared. Each these was conducted by Prescription-Event Monitoring (PEM). The exposure data derived general practitioner (GP) prescriptions confidentially supplied Prescription Pricing Authority (PPA) in England. Outcome obtained questionnaires (green...