Jorge Arnold
A5022673296- Liver Disease Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Liver Disease and Transplantation
- Hepatitis C virus research
- Diet, Metabolism, and Disease
- Drug-Induced Hepatotoxicity and Protection
- Liver Diseases and Immunity
- Helicobacter pylori-related gastroenterology studies
- Substance Abuse Treatment and Outcomes
- Alcoholism and Thiamine Deficiency
- Hepatitis B Virus Studies
- Lipid metabolism and disorders
- Organ Transplantation Techniques and Outcomes
- Hepatitis Viruses Studies and Epidemiology
- Genetic and Kidney Cyst Diseases
- Folate and B Vitamins Research
- Pharmaceutical studies and practices
- Gastrointestinal motility and disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastrointestinal Tumor Research and Treatment
- Poisoning and overdose treatments
- Homelessness and Social Issues
- Microscopic Colitis
- Diabetes and associated disorders
- Healthcare Systems and Public Health
Pontificia Universidad Católica de Chile
2021-2025
Imperial College London
2008
Agaplesion Diakonieklinikum Rotenburg
2003
Heidelberg University
1994
The long-term impact of alcohol-related public health policies (PHPs) on disease burden is unclear. We aimed to assess the association between PHPs and consequences.
ABSTRACT Several dynamic models predict mortality and corticosteroid response in alcohol‐associated hepatitis (AH), yet no consensus exists on the most effective model. This study aimed to assess predictive for short‐term severe AH within a global cohort. We conducted multi‐national of patients with treated corticosteroids at least 7 days, enrolled between 2009 2019. Dynamic models—Lille‐4, Lille‐7, trajectory serum bilirubin (TSB), neutrophil‐to‐lymphocyte ratio (NLR)—were used estimate 30‐...
We previously identified subsets of patients with NAFLD different metabolic phenotypes. Here we align metabolomic signatures cardiovascular disease (CVD) and genetic risk factors.
•AH hepatitis is associated with multi-organ failure and high short-term mortality.•MELD 3.0 predicted 30- 90-day mortality better compared the MELD-Na score mDF.•MELD was not superior to MELD ABIC scores in predicting mortality, but its classification accuracy similar between countries.•MELD best predictor of renal replacement therapy requirements other models. Background & AimsModel for End-Stage Liver Disease (MELD) predicts alcohol-associated (AH) could underestimate severity women...
Background and Aims: Alcohol-associated hepatitis (AH) poses significant short-term mortality. Existing prognostic models lack precision for 90-day Utilizing artificial intelligence in a global cohort, we sought to derive validate an enhanced model. Approach Results: The Global AlcHep initiative, retrospective study across 23 centers 12 countries, enrolled patients with AH per National Institute Alcohol Abuse Alcoholism criteria. Centers were partitioned into derivation (11 centers, 860...
Severe alcohol-associated hepatitis (sAH) is a well-characterized disease with high short-term mortality. However, there limited research on those "less severe condition" (moderate AH). This study aims to characterize in-depth patients moderate AH (mAH), including the performance of mortality scoring systems, key prognostic factors, and survival over time. A multicenter retrospective cohort (2009-2019) included mAH (MELD score ≤20 at admission). Cox regression receiver operating...
Acute-on-chronic liver failure (ACLF) is associated with reduced short-term survival, and transplantation frequently the only therapeutic option. Nonetheless, post-transplantation prognosis seems to be worse in ACLF patients.The databases of two university centers were retrospectively evaluated, adult patients cirrhosis who underwent between 2013 2020 included. One-year survival was compared that without ACLF. Variables mortality identified.A total 428 303 met inclusion criteria; 57.1% male,...
To evaluate whether push enteroscopy of the small bowel (PES), undertaken after extensive previous investigations in suspected intestinal bleeding from an uncertain site, chronic diarrhoea or lymphoma intestine, contributes to diagnosis, and ascertain results PES its clinical significance.56 consecutive patients (29 men, 27 women; mean age 63 years) were investigated prospectively. The main indications for search source 79% (group A), tropical sprue 16% B) tumour 5% C). was always performed...
This study aimed to develop a noninvasive test for identifying patients with nonalcoholic fatty liver disease (NAFLD) based on clinical and routine laboratory data.The developed model 'NAFLD test' was compared the most commonly used NAFLD scores then validated in three groups of from five centers Egypt, China, Chile. Patients were divided into discovery cohort (n = 212) validation 859). The ROC curve stepwise multivariate discriminant analysis validate evaluate its diagnostic performance,...
Hepatitis C virus (HCV) infection is characterized by a high chronicity rate. Several HCV genotypes have been described. As their distribution pattern in Germany had unknown it was the aim of this study to determine sizeable group patients and find out whether differ severity disease caused them.115 consecutive were studied prospectively, 62 (40 men, 22 women) with chronic (group 1) 53 (36 17 liver cirrhosis 2). The determined line probe assay.The mean age 1 significantly lower than that 2...
Historically, Hepatitis E infection has been thought to follow a benign clinical course. We report case of Acute in non-pregnant female, resulting the development Liver Failure necessitating liver transplant.
Abstract Background Concomitant substance use is frequent among patients with alcohol disorder (AUD), but its impact on alcohol-associated hepatitis (AH) unknown. Aims To assess the prevalence and of in hospitalized for AH a multinational cohort Latin America. Methods Multicenter prospective study including between 2015-2022. We recorded sociodemographic clinical information, data drug use. assessed consumption using competing-risk models. Results included 405 from 24 centers 8 countries...
Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related deaths worldwide. We aimed to explore HCC-related population-wide public health policies (PHP) conducted a 43-item survey about HCC: and civil society (18 questions), clinical guidelines (5 epidemiology (7 care management (13 questions). The was completed electronically (2022–2023). Data were collected in spreadsheet, revised by two independent reviewers, verified with governmental institutions, regulatory...