Gustavo Ayares
A5082492833- Liver Disease Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Liver Disease and Transplantation
- Hepatitis C virus research
- Substance Abuse Treatment and Outcomes
- Diet, Metabolism, and Disease
- Organ Transplantation Techniques and Outcomes
- Diet and metabolism studies
- Eosinophilic Esophagitis
- Alcoholism and Thiamine Deficiency
- Gastroesophageal reflux and treatments
- Liver physiology and pathology
- Hepatocellular Carcinoma Treatment and Prognosis
- Helicobacter pylori-related gastroenterology studies
- Renal Transplantation Outcomes and Treatments
- Drug-Induced Hepatotoxicity and Protection
- Healthcare Systems and Public Health
- Nutritional Studies and Diet
- SARS-CoV-2 and COVID-19 Research
- Food Security and Health in Diverse Populations
- Obesity, Physical Activity, Diet
- Pathogenesis and Treatment of Hiccups
- Gastrointestinal motility and disorders
- Oral microbiology and periodontitis research
- Hepatitis Viruses Studies and Epidemiology
Pontificia Universidad Católica de Chile
2022-2025
Finis Terrae University
2025
London Health Sciences Centre
2025
Western University
2025
The long-term impact of alcohol-related public health policies (PHPs) on disease burden is unclear. We aimed to assess the association between PHPs and consequences.
ABSTRACT Several dynamic models predict mortality and corticosteroid response in alcohol‐associated hepatitis (AH), yet no consensus exists on the most effective model. This study aimed to assess predictive for short‐term severe AH within a global cohort. We conducted multi‐national of patients with treated corticosteroids at least 7 days, enrolled between 2009 2019. Dynamic models—Lille‐4, Lille‐7, trajectory serum bilirubin (TSB), neutrophil‐to‐lymphocyte ratio (NLR)—were used estimate 30‐...
The 2023 nomenclature defined criteria for steatotic liver disease (SLD), including metabolic dysfunction-associated SLD (MASLD), alcohol-associated (ALD), and the overlapping MASLD/ALD (MetALD). We aimed to assess racial ethnic disparities in prevalence among United States (US) adults based on this new nomenclature. undertook a cross-sectional study employing 2017–2018 National Health Nutrition Examination Survey (NHANES) database. identified according controlled attenuation parameter ≥288...
•AH hepatitis is associated with multi-organ failure and high short-term mortality.•MELD 3.0 predicted 30- 90-day mortality better compared the MELD-Na score mDF.•MELD was not superior to MELD ABIC scores in predicting mortality, but its classification accuracy similar between countries.•MELD best predictor of renal replacement therapy requirements other models. Background & AimsModel for End-Stage Liver Disease (MELD) predicts alcohol-associated (AH) could underestimate severity women...
Background and Aims: Alcohol-associated hepatitis (AH) poses significant short-term mortality. Existing prognostic models lack precision for 90-day Utilizing artificial intelligence in a global cohort, we sought to derive validate an enhanced model. Approach Results: The Global AlcHep initiative, retrospective study across 23 centers 12 countries, enrolled patients with AH per National Institute Alcohol Abuse Alcoholism criteria. Centers were partitioned into derivation (11 centers, 860...
Outcomes in alcohol-associated liver disease (ALD) are influenced by several race and ethnic factors, yet its natural history across the continuum of patients different stages is unknown.
Severe alcohol-associated hepatitis (sAH) is a well-characterized disease with high short-term mortality. However, there limited research on those "less severe condition" (moderate AH). This study aims to characterize in-depth patients moderate AH (mAH), including the performance of mortality scoring systems, key prognostic factors, and survival over time. A multicenter retrospective cohort (2009-2019) included mAH (MELD score ≤20 at admission). Cox regression receiver operating...
Introduction: Infections in patients with cirrhosis are associated high morbidity and mortality. Rifaximin is an antibiotic used to treat prevent hepatic encephalopathy (HE); however, it has been suggested that may play a crucial role reducing infections these populations. Aim: To evaluate the of rifaximin preventing frequent cirrhosis-related [spontaneous bacterial peritonitis, pneumonia, urinary tract infection (UTI), bacteremia], Clostridioides difficile infection, all-cause mortality, as...
Aims: Prior evidence demonstrates an association between non-alcoholic fatty liver disease (NAFLD) and colorectal adenomas (CRA) risk. However, information using the new definition of [i.e., metabolic dysfunction-associated (MAFLD)] is scarce. We aimed to assess relationship MAFLD CRA Methods: conducted a cross-sectional study including patients from three university centers in Chile who underwent colonoscopy for cancer screening abdominal imaging study. obtained sociodemographic clinical...
Abstract Background Concomitant substance use is frequent among patients with alcohol disorder (AUD), but its impact on alcohol-associated hepatitis (AH) unknown. Aims To assess the prevalence and of in hospitalized for AH a multinational cohort Latin America. Methods Multicenter prospective study including between 2015-2022. We recorded sociodemographic clinical information, data drug use. assessed consumption using competing-risk models. Results included 405 from 24 centers 8 countries...
Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related deaths worldwide. We aimed to explore HCC-related population-wide public health policies (PHP) conducted a 43-item survey about HCC: and civil society (18 questions), clinical guidelines (5 epidemiology (7 care management (13 questions). The was completed electronically (2022–2023). Data were collected in spreadsheet, revised by two independent reviewers, verified with governmental institutions, regulatory...
Alcohol-associated hepatitis (AH) corresponds to a severe entity with high short-term mortality; however, few studies have been published in patients moderate AH. This study aimed characterize AH global study, identifying prognostic factors and survival at 30, 90, 180 days. Multi-center retrospective cohort which included (2009-2019). Moderate was defined as MELD 20 presentation. We used competing-risk models liver transplantation competing risk assess variables associated mortality. 564 (24...