Fatima Higuera‐de la Tijera
A5048679092- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Alcohol Consumption and Health Effects
- Hepatitis C virus research
- Organ Transplantation Techniques and Outcomes
- Drug-Induced Hepatotoxicity and Protection
- Liver Diseases and Immunity
- Diet, Metabolism, and Disease
- COVID-19 Clinical Research Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatitis Pathology and Treatment
- Hepatitis B Virus Studies
- Long-Term Effects of COVID-19
- Folate and B Vitamins Research
- Gastroesophageal reflux and treatments
- Alcoholism and Thiamine Deficiency
- Hepatitis Viruses Studies and Epidemiology
- Growth Hormone and Insulin-like Growth Factors
- Nutrition and Health in Aging
- SARS-CoV-2 and COVID-19 Research
- Amoebic Infections and Treatments
- Diet and metabolism studies
- Acute Kidney Injury Research
- Systemic Lupus Erythematosus Research
- Gastrointestinal motility and disorders
Hospital General de México
2016-2025
University of California, San Diego
2024
Universidad Nacional Autónoma de México
2021-2024
University of Kansas Medical Center
2024
University of Florida
2024
Patients First
2022
Instituto Nacional de las Mujeres
2017
Lakeland Regional Medical Center
2017
Creative Research Enterprises (United States)
2015-2017
Institute for Liver Health
2013
A few case reports of autoimmune hepatitis-like liver injury have been reported after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. We evaluated clinical features, treatment response and outcomes following SARS-CoV-2 vaccination in a large series.We collected data from cases 18 countries. The type was assessed with the R-value. study population categorized according to features immune-mediated hepatitis (positive autoantibodies elevated immunoglobulin G levels)...
Data regarding outcome of COVID-19 in patients with autoimmune hepatitis (AIH) are lacking.
INTRODUCTION: Several scoring systems predict mortality in alcohol-associated hepatitis (AH), including the Maddrey discriminant function (mDF) and model for end-stage liver disease (MELD) score developed United States, Glasgow alcoholic Kingdom, age, bilirubin, international normalized ratio, creatinine Spain. To date, no global studies have examined utility of these scores, nor has MELD-sodium been evaluated outcome prediction AH. In this study, we assessed accuracy different scores to...
Hospitalized patients with cirrhosis frequently undergo multiple procedures. The risk of procedural-related bleeding remains unclear, and management is not standardized. We conducted an international, prospective, multicenter study hospitalized undergoing nonsurgical procedures to establish the incidence identify factors.
AIM:To evaluate the impact of metadoxine (MTD) on 3-and 6-mo survival patients with severe alcoholic hepatitis (AH). METHODS:This study was an open-label clinical trial, performed at "Hospital General de México, Dr. Eduardo Liceaga".We randomized 135 who met criteria for AH into following groups: 35 received prednisone (PDN) 40 mg/d, PDN+MTD 500 mg three times daily, 33 pentoxifylline (PTX) 400 and 32 PTX+MTD daily.The duration treatment all groups 30 d. RESULTS:In treated MTD, Clinical...
•AH hepatitis is associated with multi-organ failure and high short-term mortality.•MELD 3.0 predicted 30- 90-day mortality better compared the MELD-Na score mDF.•MELD was not superior to MELD ABIC scores in predicting mortality, but its classification accuracy similar between countries.•MELD best predictor of renal replacement therapy requirements other models. Background & AimsModel for End-Stage Liver Disease (MELD) predicts alcohol-associated (AH) could underestimate severity women...
Background and Aims: Alcohol-associated hepatitis (AH) poses significant short-term mortality. Existing prognostic models lack precision for 90-day Utilizing artificial intelligence in a global cohort, we sought to derive validate an enhanced model. Approach Results: The Global AlcHep initiative, retrospective study across 23 centers 12 countries, enrolled patients with AH per National Institute Alcohol Abuse Alcoholism criteria. Centers were partitioned into derivation (11 centers, 860...
Background and Aims: A limited number of drugs are used as standard or alternative therapies in autoimmune hepatitis (AIH). No specific recommendations available for patients failing to respond these therapies. We analyzed the efficacy safety infliximab with AIH. Approach Results: performed a retrospective study 42 AIH who received at 21 liver centers 12 countries. Patients were categorized according reason therapy. group 1 (n=20) had failed standard, second-line (mycophenolate mofetil...
Background & Aim. Despite treatment with glucocorticoids, mortality remains high in patients severe alcoholic hepatitis. Oxidative stress and depletion of mitochondrial glutathione are implicated factors liver injury. The aim this study was to evaluate the impact addition metadoxine, a drug which possesses multifactorial mechanism action, including antioxidant properties, standard glucocorticoids Material methods. This randomized open label clinical trial performed Mexico's General Hospital...
To investigate the main current etiologies of cirrhosis in Mexico.We performed a cross-sectional retrospective multicenter study that included eight hospitals different areas Mexico. These provide health care to people diverse social classes. The inclusion criteria were histological, clinical, biochemical, endoscopic, or imaging diagnosis liver cirrhosis. Data obtained during 5-year period (January 2012-December 2017).A total 1210 patients included. mean age was 62.5 years (SD = 12.1), and...
We investigated associations between baseline use of immunosuppressive drugs and severity Coronavirus Disease 2019 (COVID-19) in autoimmune hepatitis (AIH).Data AIH patients with laboratory confirmed COVID-19 were retrospectively collected from 15 countries. The outcomes who on immunosuppression at the time compared to not medication. clinical courses classified as (i)-no hospitalization, (ii)-hospitalization without oxygen supplementation, (iii)-hospitalization supplementation by nasal...
Alcohol is the most socially accepted addictive substance worldwide, and its metabolism related with oxidative stress generation. The aim of this work was to evaluate role in alcoholic liver cirrhosis (ALC). This study included 187 patients divided into two groups: ALC, classified according Child-Pugh score, a control group. We determined levels reduced oxidized glutathione (GSH GSSG) GSH/GSSG ratio by an enzymatic method blood. Also, protein carbonyl malondialdehyde (MDA) content were...
<ns4:p><ns4:bold>Background:</ns4:bold> Nonalcoholic fatty liver disease (NAFLD) is a serious worldwide health problem, with an estimated global prevalence of 24%; it has notable relationship other metabolic disorders, like obesity and type 2 diabetes mellitus (T2DM). steatohepatitis (NASH) one the most important clinical entities NAFLD, which associated increased risk progression to cirrhosis hepatocellular carcinoma (HCC). Mexico countries highest diseases; therefore, we sought investigate...
The independent effect of liver biochemistries as a prognostic factor in patients with COVID-19 has not been completely addressed. We aimed to evaluate the value abnormal tests on admission hospitalized COVID-19. performed prospective cohort study including 1611 confirmed SARS-CoV-2 infection from April 15, 2020 through July 31, 38 different Hospitals 11 Latin American countries. registered clinical and laboratory parameters, function tests, during hospitalization. All were followed until...
As of January 2021, over 88 million people have been infected with COVID-19. Almost two died severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A high SOFA score and a D-Dimer >1 µg/mL identifies patients risk mortality. High lactate dehydrogenase (LDH) levels on admission are associated severity Different degrees alanine aminotransferase (ALT) and/or aspartate (AST) abnormalities reported in these patients, its association mortality remains controversial. The aim this study was...
Cut-points for non-invasive tests (NITs) risk stratification in metabolic dysfunction-associated steatotic liver disease (MASLD) were derived from predominantly non-Hispanic populations. It is unknown if these cut-points perform adequately Hispanic individuals. We assessed the performance characteristics of current NIT among patients and determined whether they could be further optimized.