A5013743804- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatitis C virus research
- Organ Transplantation Techniques and Outcomes
- Hepatitis B Virus Studies
- Drug-Induced Hepatotoxicity and Protection
- Liver Diseases and Immunity
- Hepatocellular Carcinoma Treatment and Prognosis
- Pediatric Hepatobiliary Diseases and Treatments
- Amoebic Infections and Treatments
- Pancreatitis Pathology and Treatment
- Alcohol Consumption and Health Effects
- Cardiac Ischemia and Reperfusion
- Liver physiology and pathology
- Systemic Lupus Erythematosus Research
- Hepatitis Viruses Studies and Epidemiology
- Galaxies: Formation, Evolution, Phenomena
- Renal Transplantation Outcomes and Treatments
- Metabolism and Genetic Disorders
- Parasitic Infections and Diagnostics
- Natural Antidiabetic Agents Studies
- Diet, Metabolism, and Disease
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Diet and metabolism studies
- Cardiovascular Function and Risk Factors
Universidad Autónoma de Nuevo León
2016-2025
Universidade de São Paulo
2023-2024
Hospital Universitario Dr José Eleuterio Gonzalez
2013-2024
University of Monterrey
1992-2023
Museu de Astronomia e Ciências Afins
2023
Centre Hospitalier Universitaire de Grenoble
2022
Hospital Universitario Austral
2022
Austral University
2022
Paris-Est Sup
2022
Université Paris-Est Créteil
2022
The p53 tumor suppressor gene is commonly mutated in human hepatocellular carcinoma (HCC). most frequent mutation HCC populations exposed to a high dietary intake of aflatoxin Bl (AFB1) an AGG arg →AGT ser mis-sense codon 249 the gene. We analyzed HCCs from Monterrey, Mexico, for hotspot mutation. also serum AFB1-albumin adduct levels donors and family members measure current AFB1 exposure this population. Moreover, presence hepatitis B and/or C viral infection (HBV or HCV) was serologically...
In a series of 218 patients diagnosed as having primary biliary cirrhosis only nine exhibited negative serum mitochondrial antibody. On examining additional specimens from these patients, seven were found to be positive, giving final incidence greater than 99%. The two whose sera remained for the antibody had liver histology compatible with diagnosis cirrhosis, but firm could not reached. Three positive subjects who asymptomatic and normal alkaline phosphatase shown on biopsy have stage I...
The French alpha-fetoprotein (AFP) model has recently shown superior results compared to Milan criteria (MC) for prediction of hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT) in European populations. aim this study was explore the predictive capacity AFP HCC a Latin-American cohort.Three hundred twenty-seven patients with were included from total 2018 transplanted at 15 centres. Serum and imaging data both recorded listing. Predictability assessed by Net...
The worldwide increment of multidrug- and extensively drug-resistant tuberculosis has emphasized the importance looking for new options in therapeutics. Long-time usage or higher doses isoniazid rifampicin have been considered treatment multidrug-resistant tuberculosis; however, risk liver failure is proportionally increased. Hepatocyte growth factor (HGF) a multitask that stimulates both antiapoptotic antioxidant responses counteract toxic effects drug metabolism liver. present work was...
Background: In the last decades it has been suggested that main cause of liver cirrhosis in Mexico is alcohol. Currently Western countries hepatitis C virus (HCV) infection one leading causes endstage disease and transplantation. Mexico, we have no data relative to etiology cirrhosis. The aim this study was investigate Mexico. Methods: Eight hospitals located different areas country were invited participate study. Those provide health care social classes country. inclusion criteria presence...
Aims. To define the prevalence and clinical characteristics of glucose metabolism disorders (GMD) in patients with compensated liver cirrhosis (LC). Material methods. Fasting plasma (FPG) levels were measured to 130 clinically stable LC. Oral tolerance tests (OGTT) fasting insulin determinations performed normal FPG. Insulin resistance (IR) was calculated HOMA2-IR index. GMD classified according FPG OGTT results chronologic relation between diagnosis diabetes mellitus (DM) LC as follows:...
It has been suggested that DM may reduce survival of patients with liver cirrhosis (LC). Nevertheless only few prospective studies assessing the impact on mortality cirrhotic have published, none in compensated LC.(i) to study and (ii) identify predictors death.Patients LC without were studied. Survival was analyzed by Kaplan-Meier Method. Univariate multivariate analysis performed determine independent mortality.110 included: 60 50 DM. Diabetic had significantly higher frequency cryptogenic...
In vitro bioassays are important in the evaluation of plants with possible hepatoprotective effects. The aims this study were to evaluate pretreatment HepG2 cells agents against damage induced by carbon tetrachloride (CCl4) and paracetamol (APAP). Antioxidative activity was measured using an assay measure 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging. hepatotoxicity CCl4 APAP, cytotoxic properties silymarin (SLM), silybinin (SLB), silyphos (SLP) evaluated measuring cell...
Abstract Background and aims Pirfenidone (PFD), an oral antifibrotic drug, has been authorized by the EMA FDA for treatment of idiopathic pulmonary fibrosis. Few studies have addressed its use in advanced liver fibrosis (ALF). We evaluated a prolonged-release formulation (PR-PFD) plus standard care on disease progression ALF. Methods 281 ALF patients from 12 centers receiving PR-PFD (600 mg bid) were screened; 122 completed 1 year treatment. Additionally, 74 received only regimen. Average...
Background Obesity is associated with low-grade inflammation and metabolic syndrome (MetS) in both children adults. Our aim was to describe metabolic, inflammatory adipokine differences on overweight/obese without MetS. Methods This an observational study. A total of 107 adolescents aged 6–18 years were included. Among this sample, n = 21 had normal body weight, 22 overweight/obesity MetS, 64 Anthropometric data biochemical, adipokine, markers measured. Different ratios then assessed for...
Plant extracts with antioxidant activities have shown nephroprotection against IR injury. Jatropha dioica (Jd) possesses activity. Our aim was to evaluate the effects of a hydroalcoholic Jd extract injury in Wistar rats. Rats were divided into groups (n = 6): sham (SH); no toxicity (JdTox; 300 mg/kg/day for 7 days); (on day [I: 45 min/R: 24 h]); and Jd+IR (same treatment as JdTox; same surgical procedure IR). AST LDH significantly lower JdTox. exhibited higher CrS, BUN, MDA compared SH;...
Alcohol is the most socially accepted addictive substance worldwide, and its metabolism related with oxidative stress generation. The aim of this work was to evaluate role in alcoholic liver cirrhosis (ALC). This study included 187 patients divided into two groups: ALC, classified according Child-Pugh score, a control group. We determined levels reduced oxidized glutathione (GSH GSSG) GSH/GSSG ratio by an enzymatic method blood. Also, protein carbonyl malondialdehyde (MDA) content were...
Cholesterol overload in the liver has shown toxic effects by inducing aggravation of nonalcoholic fatty disease to steatohepatitis and sensitizing damage. Although mechanism damage is complex, it been demonstrated that oxidative stress plays a prominent role process. In addition, we have proved hepatocyte growth factor induces an antioxidant response hepatic cells; present work aimed figure out protective effect this hepatocytes overloaded with free cholesterol. Hepatocytes from mice fed...
Patients with hepatocellular carcinoma (HCC) are selected for liver transplantation (LT) based on pre-LT imaging ± alpha-foetoprotein (AFP) level, but discrepancies between tumour assessment and explant frequent. Our aim was to design an explant-based recurrence risk reassessment score refine prediction of after LT provide a framework guide post-LT management.Adult patients who underwent 2000 2018 HCC in 47 centres were included. A model developed using competing-risk regression analysis...
It is essential to identify a serological marker of injury in order study the pathophysiology intestinal ischemia reperfusion. In this work, we studied evolution several markers after reperfusion rats. The non-specific cell damage were aspartate aminotransferase, alanine aminotransaminase, and lactic dehydrogenase, inflammation tumor necrosis factor alpha, interleukin-6, interleukin-1 beta, mucosal fatty acid binding protein D-lactate. We used Chiús classification grade histopathological...
Kidney ischemia-reperfusion (I/R) injury is the main cause of delayed graft function in solid organ transplantation. Sonchus oleraceus a plant with well-known antioxidant and anti-inflammatory activities; however, its effects on renal I/R are unknown.To evaluate whether S. extract (S.O.e.) has nephroprotective activity an model Wistar rats.Animal groups (n = 6): sham, (45 min/15 h), S.O.e (300 mg/kg p.o.), + mg/kg, p.o.; 45 h). Renal function, proinflammatory cytokines, alanine...
Background. Centaurea americana, Krameria ramosissima, Juglans mollis and Turnera diffusa are used by traditional healers in the northeastern region of Mexico to protect against liver damage. However, hepatoprotective properties these plants have not been investigated scientifically. This study reports on protective effects using an vitro assay. Material methods. Extracts were tested for antioxidant activity 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method. The extracts from a...
AIM:To determine if subclinical abnormal glucose tolerance (SAGT) has influence on survival of non-diabetic patients with liver cirrhosis. METHODS:In total, 100 compensated
Sepsis is a serious condition characterized by an infectious process that induces severe systemic inflammatory response. In this study, the effects of gemfibrozil (GFZ) on response associated with abdominal sepsis were investigated using rat model cecal‑ligation and puncture (CLP). Male Wistar rats randomly divided into three groups: Sham‑operated group (sham), where laparotomy was performed, intestines manipulated, cecum ligated but not punctured; control group, subjected to CLP; GFZ which...
The aim of this study was to assess the effects molecular absorbent recirculating system (MARS) on patients with acute liver failure (ALF) and cirrhosis (AoCLF) as well in cholestatic intractable pruritus a Mexican population.From August 2003 December 2011, MARS used 38 ALF, 15 AoCLF, 17 pruritus. were examined using standard function test for vital signs, presence ascites encephalopathy before after each treatment. therapeutic response, patient status, follow-up need transplantation...
Non-alcoholic fatty liver disease (NAFLD) and progression to non-alcoholic steatohepatitis (NASH) result as a consequence of diverse conditions, mainly unbalanced diets. Particularly, high-fat cholesterol content, well carbohydrates, such those commonly ingested in Western countries, frequently drive adverse metabolic alterations the promote NAFLD development. Lipid overload is also one main risk factors for initiation hepatocellular carcinoma (HCC), but detailed knowledge on relevance high...