A5026454685- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Diseases and Immunity
- Acute Ischemic Stroke Management
- Diet, Metabolism, and Disease
- Systemic Sclerosis and Related Diseases
- Hepatitis C virus research
- Venous Thromboembolism Diagnosis and Management
- Vascular Malformations Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Herpesvirus Infections and Treatments
- Diabetes Management and Education
- Traumatic Brain Injury and Neurovascular Disturbances
- Chemotherapy-induced cardiotoxicity and mitigation
- Stroke Rehabilitation and Recovery
- Genetic Associations and Epidemiology
- Cancer, Hypoxia, and Metabolism
- Iron Metabolism and Disorders
- Neurological Disorders and Treatments
- Diet and metabolism studies
- Cancer Treatment and Pharmacology
- Folate and B Vitamins Research
University of California, San Diego
2023-2024
Shaukat Khanum Memorial Cancer Hospital and Research Center
2024
CentraCare Health System
2014-2015
University of Minnesota
2014
Background Dynamic changes in non-invasive tests, such as alanine aminotransferase (ALT) and MRI proton-density-fat-fraction (MRI-PDFF), may help to detect metabolic dysfunction-associated steatohepatitis (MASH) resolution, but a combination of tests be more accurate than either alone. We developed novel score, the MASH Resolution Index, histological resolution MASH. Methods This study included derivation cohort 95 well-characterised adult participants (67% female) with biopsy-confirmed who...
ABSTRACT Background Elevated levels of serum ferritin, a marker hepatic iron overload and inflammation, may be associated with metabolic dysfunction‐associated steatotic liver disease (MASLD) fibrosis. Aim To determine the prevalence MASLD significant fibrosis among patients type 2 diabetes mellitus (T2DM) hyperferritinaemia. Methods This is cross‐sectional analysis prospective cohort 523 adults (64% female) aged 50–80 T2DM without diagnosis haemochromatosis. were defined as magnetic...
Summary Background There are limited data on the prevalence and treatment of at‐risk metabolic dysfunction‐associated steatohepatitis (MASH) among patients with type 2 diabetes (T2DM) in United States. Aim To estimate MASH a prospectively recruited cohort adults T2DM using new nomenclature endorsed by multiple societies. Methods This prospective study enrolled aged ≥50 from primary care endocrinology clinics southern California 2016 to 2023. Metabolic steatotic liver disease (MASLD) was...
Summary Background Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are independent risk factors for cardiovascular (CVD). Aims To examine the clinical utility of fat quantification determining CVD among a well‐phenotyped cohort patients with T2DM. Methods This was cross‐sectional analysis prospective adults aged ≥50 Liver quantified magnetic resonance imaging proton‐density‐fat‐fraction (MRI‐PDFF), an advanced imaging‐based biomarker. Patients were stratified...
Summary Background & Aims The natural progression of hepatic decompensation in metabolic dysfunction‐associated steatotic liver disease (MASLD) is not well‐characterised. We aimed to describe it by conducting a retrospective analysis. Methods This longitudinal, analysis well‐characterised MASLD cohorts followed for and death. sequence liver‐related events was evaluated, the median time between episodes death versus. transplantation measured. Results Of 2016 patients identified, 220 (11%)...
Cut-points for non-invasive tests (NITs) risk stratification in metabolic dysfunction-associated steatotic liver disease (MASLD) were derived from predominantly non-Hispanic populations. It is unknown if these cut-points perform adequately Hispanic individuals. We assessed the performance characteristics of current NIT among patients and determined whether they could be further optimized.
Objective: To evaluate the frequency of objective response Capecitabine and Oxaliplatin (CAPOX) in patients with metastatic colorectal cancer.Study Design: A descriptive case study.Place Duration Study: The Study was conducted at Oncology Department, Hameed Lateef Hospital Lahore, Pakistan from 17th July 2019 to 16th January 2020.Methods: total 80 participants aged 20-80 who were diagnosed carcinoma selected for study. After baseline investigations examination, all advised chemotherapy...
Ultrasound (US) is associated with severe visualization limitations (US Liver Imaging Reporting and Data System score C) in one-third of patients nonalcoholic fatty liver disease (NAFLD) cirrhosis undergoing hepatocellular carcinoma (HCC) screening. suggest abbreviated MRI (aMRI) may improve HCC screening efficacy. This study analyzed the cost-effectiveness strategies, including an US score-based approach aMRI, NAFLD cirrhosis.
Summary Background and Aims Magnetic resonance elastography (MRE) vibration‐controlled transient (VCTE) have the potential to assess disease progression; however, repeatability data in people with cirrhosis are lacking. We aimed effect of severity on measurement variability contribute evidentiary basis for qualification repeating liver stiffness measurements (LSM) practice research. Methods This prospective study included 49 adult participants (58.3% female) who underwent same‐day repeat LSM...
A noteworthy proportion of patients with metabolic dysfunction-associated steatotic liver disease (MASLD) have an indeterminate vibration-controlled transient elastography (VCTE). Among these patients, we aimed to identify candidates for MASLD treatment by diagnosing significant fibrosis.
Background: A delay in endovascular treatment is less likely if acute ischemic stroke patients proceed from emergency department(ED) to computed tomographic (CT) scanner and directly angiographic suite (no turn back approach). We determined the feasibility of “no approach” its effect on times patient outcomes. Methods: The primary outcomes were procedures performed with a time interval: 1) between ED arrival microcatheter placement <120 minutes; 2) CT scan acquisition <90 minutes....
Objective: We determined the feasibility of “no turn back approach” and its effect on treatment times patient outcomes. Background: A delay in endovascular is less likely if acute ischemic stroke patients proceed from emergency department(ED) to computed tomographic (CT) scanner directly angiographic suite (no approach). Design/Methods: The primary outcomes were procedures performed with a time interval: 1) between ED arrival microcatheter placement <120 minutes; 2) CT scan acquisition <90...