A5073289665- Inflammatory Bowel Disease
- Microscopic Colitis
- Vitamin D Research Studies
- Diverticular Disease and Complications
- Celiac Disease Research and Management
- Eosinophilic Esophagitis
- Helicobacter pylori-related gastroenterology studies
- Reproductive System and Pregnancy
- Diagnosis and treatment of tuberculosis
- Pregnancy and Medication Impact
- Clostridium difficile and Clostridium perfringens research
- Gastric Cancer Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Hepatitis C virus research
- Anorectal Disease Treatments and Outcomes
- Colorectal Cancer Surgical Treatments
- Immune Cell Function and Interaction
- Nutritional Studies and Diet
- Genetic factors in colorectal cancer
- Urticaria and Related Conditions
- Liver Disease Diagnosis and Treatment
- Nutrition and Health in Aging
- Immunodeficiency and Autoimmune Disorders
- Colorectal Cancer Screening and Detection
- Liver Diseases and Immunity
Scripps Clinic
2015-2024
University of North Carolina at Chapel Hill
2023
Scripps Green Hospital
2019-2023
Scripps Health
2018-2022
Massachusetts General Hospital
2013-2019
Harvard University
2013-2019
University of Pennsylvania
2019
Scripps Research Institute
2015-2018
Boston University
2015
Obesity is associated with intestinal-specific inflammation. Nonetheless, a specific role of obesity in the etiology inflammatory bowel disease unclear.
Clostridium difficile infection (CDI) is an important cause of morbidity and healthcare costs, characterized by high rates disease recurrence. The cost-effectiveness newer treatments for recurrent CDI has not been examined, yet would be to inform clinical practice. aim this study was analyze the cost effectiveness competing strategies CDI.We constructed a decision-analytic model comparing 4 treatment first-line in population with median age 65 years: metronidazole, vancomycin, fidaxomicin,...
<b>Objective</b> To examine the association between physical activity and risk of ulcerative colitis Crohn's disease. <b>Design</b> Prospective cohort study. <b>Setting</b> Nurses' Health Study II. <b>Participants</b> 194 711 women enrolled in II who provided data on other factors every two to four years since 1984 1989 followed up through 2010. <b>Main outcome measure</b> Incident <b>Results</b> During 3 421 972 person follow-up, we documented 284 cases disease 363 colitis. The was...
Introduction : Emerging evidence supports an immunologic role for 25‐hydroxyvitamin D (25(OH)D) in inflammatory bowel disease (IBD). Here we examined if pretreatment vitamin status influences durability of anti–tumor necrosis factor (TNF)–α therapy patients with Crohn's (CD) or ulcerative colitis (UC). Methods All IBD who had plasma 25(OH)D level checked <3 months prior to initiating anti–TNF‐α were included this retrospective single‐center cohort study. Our main predictor variable was...
Data suggest dietary modification can improve clinical responses in inflammatory bowel disease (IBD). The goal of this study was to determine the efficacy an autoimmune protocol diet patients with Crohn's and ulcerative colitis.We enrolled adults active IBD (Harvey-Bradshaw index ≥ 5 or partial Mayo score ≥3 erosions on endoscopy and/or elevated fecal calprotectin). For protocol, underwent 6-week elimination followed by 5-week maintenance phase. Clinical indices, laboratories, biomarkers...
Abstract Diet is an environmental exposure implicated in the development of inflammatory bowel disease (IBD), including Crohn's (CD) and ulcerative colitis (UC). Dietary therapy also a tool for management these conditions. Nutrition IBD has been shown to reduce intestinal inflammation, promote healing, alleviate symptoms, as well improve patients' nutrition status. Although mechanisms action most therapies are not understood, diets theorized eliminate triggers gut dysbiosis mucosal immune...
Inflammatory bowel disease (IBD) is a well-known risk factor for venous thromboembolism (VTE). Existing guidelines thromboprophylaxis in hospitalized patients do not extend to other clinical scenarios that may also be associated with VTE risk. Our aim was estimate the fraction of events IBD could prevented.A retrospective analysis assessed all diagnosed at single academic medical center from 2002 2012. Confirmed cases were analyzed factors, inpatient status, use deep thrombosis prophylaxis,...
Abstract Context: Although studies have linked vitamin D deficiency with immune-mediated diseases, data demonstrating a direct effect on T-cell function are sparse. Objective: Our objective was to determine whether oral D3 influences activation in humans deficiency. Design: This single-center ancillary study within Vitamin Therapy Individuals at High Risk of Hypertension, double-blind, multicenter, randomized controlled trial. Setting: undertaken single academic medical center. Participants:...
Total circulating 25-hydroxyvitamin D [25(OH)D)] has been associated with lower risk of colorectal cancer. The physiologic mechanism, however, may be more directly related to the free or bioavailable fraction 25(OH)D, which is influenced by levels vitamin binding protein (VDBP). We assessed association prediagnosis total, free, and 25(OH)D VDBP cancer among predominantly white women in Nurses' Health Study (NHS) who provided a blood specimen 1989-1990. documented 378 cases through 2011...
Abstract Background Tofacitinib is an oral, small-molecule JAK inhibitor for the treatment of ulcerative colitis (UC). Using a novel electronic reporting tool, we aimed to prospectively describe onset tofacitinib efficacy during induction therapy in real-world study. Methods Patient-reported outcome data (PROs) including simple clinical activity index (SCCAI), PRO Measurement Identification Systems (PROMIS) measures, and adverse events were collected daily first 14 days at day 28 56. Paired...
Temporary fecal diversion has been used to allow severe perianal Crohn's disease (CD) heal. Most data on intestinal reconnection rates precede the biological era with limited patient follow-up after reconnection. We, therefore, sought evaluate natural history of CD diversion.We identified 49 patients and involvement who underwent between 1991 2011 at a tertiary referral care center. Demographics, medication use, onset extent disease, surgical interventions were abstracted. We determined...
Ultrasound (US) is associated with severe visualization limitations (US Liver Imaging Reporting and Data System score C) in one-third of patients nonalcoholic fatty liver disease (NAFLD) cirrhosis undergoing hepatocellular carcinoma (HCC) screening. suggest abbreviated MRI (aMRI) may improve HCC screening efficacy. This study analyzed the cost-effectiveness strategies, including an US score-based approach aMRI, NAFLD cirrhosis.
Crohn's disease (CD) requires surgical management in up to two-thirds of patients. Few studies have addressed the issue ileal recurrence after colectomy and permanent ileostomy. The aims our study were assess rate predictors postoperative CD patients with ileostomy.In a retrospective from tertiary referral center, we analyzed natural history who underwent total Our primary outcomes (1) overall including luminal recurrence, perianal or peristomal lesions requiring therapy, (2) alone defined...
BackgroundAndrogens, which are known to be altered by exogenous hormone use, have recently been linked alterations of the gut microbiome and mucosal immune function. No study has evaluated association between circulating levels androgens risk Crohn's disease (CD) ulcerative colitis (UC).
Abstract Background Prior studies suggest dietary modification may improve clinical response or remission rates in patients with inflammatory bowel disease (IBD). Our aim was to examine whether an autoimmune protocol diet improves quality of life active Crohn (CD) and ulcerative colitis (UC). Methods We conducted uncontrolled trial the adult IBD (Harvey–Bradshaw Index ≥ 5 for CD partial Mayo score 3 UC, erosions/ulcers on endoscopy and/or elevated fecal calprotectin). The intervention...