A5086882609- Dementia and Cognitive Impairment Research
- Mitochondrial Function and Pathology
- Liver Disease Diagnosis and Treatment
- Hormonal and reproductive studies
- Chronic Kidney Disease and Diabetes
- Adipose Tissue and Metabolism
- Nutritional Studies and Diet
- Blood Pressure and Hypertension Studies
- Urinary Bladder and Prostate Research
- Diet and metabolism studies
- Substance Abuse Treatment and Outcomes
- Dialysis and Renal Disease Management
- Prostate Cancer Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Cardiovascular Health and Disease Prevention
- Hypothalamic control of reproductive hormones
- Hemophilia Treatment and Research
- Blood Coagulation and Thrombosis Mechanisms
- Liver Disease and Transplantation
- Alzheimer's disease research and treatments
- Regulation of Appetite and Obesity
- Health, Environment, Cognitive Aging
- Renal Diseases and Glomerulopathies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Aging and Gerontology Research
University of California, San Diego
2015-2025
Health and Human Services Agency
2023
Landscape Research Group
2023
Authorised Association Consortium
2023
Human Longevity (United States)
2022
University of Washington
2017
Scripps Research Institute
2013
Orthopaedic Hospital
2013
Tulane University
2013
University of Cambridge
2012
Declining testosterone levels in elderly men are thought to underlie many of the symptoms and diseases aging; however, studies demonstrating associations low with clinical outcomes few.The objective study was examine association endogenous mortality older community-dwelling men.This a prospective, population-based 794 men, aged 50-91 (median 73.6) yr who had serum measurements at baseline (1984-1987) were followed for through July 2004.All-cause by level measured.During an average 11.8-yr...
The burden of premature death and health loss from ESRD is well described. Less known regarding the cardiovascular disease attributable to reduced GFR. We estimated prevalence GFR categories 3, 4, 5 (not on RRT) for 188 countries at six time points 1990 2013. Relative risks outcomes by three were calculated pooled random effects meta-analysis. Results are presented as deaths disability-adjusted life years disease, 5, ESRD. In 2013, was associated with 4% worldwide, or 2.2 million (95%...
The pathophysiology of exercise intolerance in patients with heart failure preserved ejection fraction (HFpEF) remains incompletely understood. Multiple lines evidence suggest that abnormal skeletal muscle metabolism is a key contributor, but the mechanisms underlying metabolic dysfunction remain unresolved.
Abstract Background Hearing impairment is prevalent among older adults and has been identified as a risk factor for cognitive dementia. We evaluated the association of hearing with long-term decline community-dwelling adults. Methods A population-based longitudinal study not using aids who had acuity function assessed in 1992–1996, were followed maximum 24 years up to five additional assessments. was categorized based on pure-tone average (PTA) thresholds: normal (PTA ≤ 25 dB), mild >...
We previously demonstrated in adult patients with haemophilia (PWH) that hemarthrosis is present only ~1/3rd of acutely painful joints by using point-of-care-musculoskeletal ultrasound (MSKUS). Therefore, other unrecognized tissue abnormalities must contribute to pain. Using high resolution MSKUS, employing grey scale and power Doppler, we sought retrospectively (i) investigate soft haemophilic (ii) determine what extent MSKUS findings, functional or radiographic joint scores correlate...
The apolipoprotein E (APOE) gene is an established risk factor for sporadic Alzheimer's disease, with elevated ε4-carriers and reduced ε2-carriers. However, it unclear whether APOE modifies cognitive decline in normal aging. objective of this study was to determine ε2 ε4 are associated rates aging, associations modified by sex, education or health behaviors (exercise, alcohol consumption, smoking).A community-based sample 1,393 older adults were genotyped underwent assessment up seven times...
Summary Background Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are independent risk factors for cardiovascular (CVD). Aims To examine the clinical utility of fat quantification determining CVD among a well‐phenotyped cohort patients with T2DM. Methods This was cross‐sectional analysis prospective adults aged ≥50 Liver quantified magnetic resonance imaging proton‐density‐fat‐fraction (MRI‐PDFF), an advanced imaging‐based biomarker. Patients were stratified...
To examine the associations of serum lipids and lipoproteins with benign prostatic hyperplasia (BPH) in community-dwelling men.This analysis was conducted within Rancho Bernardo Study, a prospective, community-based cohort study. BPH defined as history prostate surgery for other than cancer, or medical diagnosis BPH. Logistic regression modelling, adjustments age stratification by diabetes diagnosis, used to estimate odds ratio (OR) associated fasting concentrations total cholesterol,...
Hypertension (HTN) is a major risk factor for intracranial hemorrhage. We, therefore, investigated the prevalence, treatment, and control of HTN in adult patients with hemophilia (PWH). PWH≥18 years (n=458) from 3 geographically different cohorts United States were evaluated retrospectively factors. Results compared nationally representative sample provided by contemporary National Health Nutrition Examination Survey (NHANES). PWH had significantly higher prevalence NHANES. Overall, was...
Background and Aims: Magnetic resonance elastography (MRE) is an accurate, continuous biomarker of liver fibrosis; however, the optimal combination with clinical factors to predict risk incident hepatic decompensation unknown. Therefore, we aimed develop validate MRE-based prediction model for patients NAFLD. Approach Results: This international multicenter cohort study included participants NAFLD undergoing MRE from 6 hospitals. A total 1254 were randomly assigned as training (n = 627)...
OBJECTIVE— Levels of adiposity-signaling hormones and inflammatory markers are less favorable in individuals with the metabolic syndrome; their role association between syndrome cardiovascular mortality remains unclear. RESEARCH DESIGN AND METHODS— We conducted a prospective study 977 men 1,141 women aged 40–94 years 1984–1987, followed for maximum 20 years. Adiponectin, leptin, ghrelin, interleukin-6 (IL-6), C-reactive protein (CRP), Adult Treatment Panel III–defined components were...
Context: Ghrelin may be one of the pathophysiological mechanisms underlying risk factor clustering observed in metabolic syndrome, but this has not been investigated. Objective: The objective work was to study association between ghrelin and syndrome identify social behavioral determinants ghrelin. Design: This a cross-sectional study. Setting: setting Rancho Bernardo Study. Participants: Study subjects included 1513 men women, aged 51–90 yr 1984–1987. Outcomes: Total ghrelin, measured by...
Objective : The role of osteoprotegerin (OPG) and its receptor activator nuclear factor κB legend (RANKL) in the regulation bone humans remain unclear. We examined sex-specific associations serum OPG, RANKL, their ratio with mineral density (BMD) older adults. Design Participants were 681 community-dwelling adults, ages 45–90 years, who had OPG RANKL measured scans 1988–1991, follow-up 5 and/or 10 years later. Methods Analyses sex-specific; women using not estrogen evaluated separately....
To evaluate serum sex steroid hormone concentrations and long-term risk of subsequent lower urinary tract symptoms (LUTS) in a cohort community-dwelling older men.Between 1984 1987, were measured participants the Rancho Bernardo Study, prospective, community-based study. In 2006, American Urological Association Symptom Index (AUA-SI) was mailed to surviving male participants. Logistic regression used examine associations baseline with AUA-SI.Among 158 men complete data no history prostate...
physical activity in older age has been associated with better cognitive function, but the role of earlier life is less well understood.