Francisco Idalsoaga
A5040861714- Liver Disease Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Liver Disease and Transplantation
- Diet, Metabolism, and Disease
- Hepatitis C virus research
- Substance Abuse Treatment and Outcomes
- Alcoholism and Thiamine Deficiency
- Drug-Induced Hepatotoxicity and Protection
- Eosinophilic Esophagitis
- Travel-related health issues
- Drug Transport and Resistance Mechanisms
- Helicobacter pylori-related gastroenterology studies
- COVID-19 Clinical Research Studies
- Global Public Health Policies and Epidemiology
- Diet and metabolism studies
- Healthcare Systems and Public Health
- Gastroesophageal reflux and treatments
- Organ Transplantation Techniques and Outcomes
- Liver physiology and pathology
- Clinical Nutrition and Gastroenterology
- Renal Transplantation Outcomes and Treatments
- Dental Health and Care Utilization
- Nutritional Studies and Diet
- Cannabis and Cannabinoid Research
- Hepatocellular Carcinoma Treatment and Prognosis
Pontificia Universidad Católica de Chile
2020-2025
Western University
2024-2025
London Health Sciences Centre
2024-2025
The long-term impact of alcohol-related public health policies (PHPs) on disease burden is unclear. We aimed to assess the association between PHPs and consequences.
Alcohol represents a leading burden of disease worldwide, including alcohol use disorder (AUD) and alcohol-related liver (ALD). We aim to assess the global AUD, ALD, alcohol-attributable primary cancer between 2000-2021. registered regional trends using data from Global Burden Disease 2021 Study, largest most up-to-date epidemiology database. estimated annual percent change (APC) its 95% confidence interval (CI) changes in age-standardized rates over time. In 2021, there were 111.12 million...
ABSTRACT Several dynamic models predict mortality and corticosteroid response in alcohol‐associated hepatitis (AH), yet no consensus exists on the most effective model. This study aimed to assess predictive for short‐term severe AH within a global cohort. We conducted multi‐national of patients with treated corticosteroids at least 7 days, enrolled between 2009 2019. Dynamic models—Lille‐4, Lille‐7, trajectory serum bilirubin (TSB), neutrophil‐to‐lymphocyte ratio (NLR)—were used estimate 30‐...
The 2023 nomenclature defined criteria for steatotic liver disease (SLD), including metabolic dysfunction-associated SLD (MASLD), alcohol-associated (ALD), and the overlapping MASLD/ALD (MetALD). We aimed to assess racial ethnic disparities in prevalence among United States (US) adults based on this new nomenclature. undertook a cross-sectional study employing 2017–2018 National Health Nutrition Examination Survey (NHANES) database. identified according controlled attenuation parameter ≥288...
Background and Aims Alcohol‐associated liver disease (ALD) is the leading cause of liver‐related mortality in Latin America, yet impact public health policies (PHP) on unknown. We aimed to assess association between alcohol PHP deaths due ALD American countries. Approach Results performed an ecological multinational study including 20 countries America (628,466,088 inhabitants). obtained country‐level sociodemographic information from World Bank Open Data source. Alcohol‐related data for...
•AH hepatitis is associated with multi-organ failure and high short-term mortality.•MELD 3.0 predicted 30- 90-day mortality better compared the MELD-Na score mDF.•MELD was not superior to MELD ABIC scores in predicting mortality, but its classification accuracy similar between countries.•MELD best predictor of renal replacement therapy requirements other models. Background & AimsModel for End-Stage Liver Disease (MELD) predicts alcohol-associated (AH) could underestimate severity women...
Background and Aims: Alcohol-associated hepatitis (AH) poses significant short-term mortality. Existing prognostic models lack precision for 90-day Utilizing artificial intelligence in a global cohort, we sought to derive validate an enhanced model. Approach Results: The Global AlcHep initiative, retrospective study across 23 centers 12 countries, enrolled patients with AH per National Institute Alcohol Abuse Alcoholism criteria. Centers were partitioned into derivation (11 centers, 860...
Outcomes in alcohol-associated liver disease (ALD) are influenced by several race and ethnic factors, yet its natural history across the continuum of patients different stages is unknown.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is one of the leading causes chronic globally. Based on 2023 definition, MASLD characterized by presence metabolic dysfunction and limited alcohol consumption (<140 grams/week for women, <210 men). Given significant burden in Latin America, this guidance was developed American Association Study Liver (ALEH) Working Group to address key aspects its clinical assessment therapeutic strategies. In ultrasonography recommended as...
Severe alcohol-associated hepatitis (sAH) is a well-characterized disease with high short-term mortality. However, there limited research on those "less severe condition" (moderate AH). This study aims to characterize in-depth patients moderate AH (mAH), including the performance of mortality scoring systems, key prognostic factors, and survival over time. A multicenter retrospective cohort (2009-2019) included mAH (MELD score ≤20 at admission). Cox regression receiver operating...