A5016905228- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Alcohol Consumption and Health Effects
- Hepatocellular Carcinoma Treatment and Prognosis
- Organ Transplantation Techniques and Outcomes
- Hepatitis C virus research
- Liver Diseases and Immunity
- COVID-19 and healthcare impacts
- Drug-Induced Hepatotoxicity and Protection
- Multiple and Secondary Primary Cancers
- Telemedicine and Telehealth Implementation
- Diverticular Disease and Complications
- Hormonal and reproductive studies
- Electrolyte and hormonal disorders
- Global Health Care Issues
- Hepatitis Viruses Studies and Epidemiology
- COVID-19 Clinical Research Studies
- Romani and Gypsy Studies
- Endoplasmic Reticulum Stress and Disease
- Pharmacological Effects and Toxicity Studies
- Renal Transplantation Outcomes and Treatments
- Urinary and Genital Oncology Studies
- Economic and Financial Impacts of Cancer
- Diet, Metabolism, and Disease
- Hepatitis B Virus Studies
Roosevelt Hospital
2024-2025
Slovak Medical University
2017-2025
Roosevelt University
2024
ABSTRACT Several dynamic models predict mortality and corticosteroid response in alcohol‐associated hepatitis (AH), yet no consensus exists on the most effective model. This study aimed to assess predictive for short‐term severe AH within a global cohort. We conducted multi‐national of patients with treated corticosteroids at least 7 days, enrolled between 2009 2019. Dynamic models—Lille‐4, Lille‐7, trajectory serum bilirubin (TSB), neutrophil‐to‐lymphocyte ratio (NLR)—were used estimate 30‐...
Abstract Background and aims Alcohol-associated hepatitis (AH) frequently triggers acute decompensation (AD) in cirrhosis, with severe AH linked to high short-term mortality, especially acute-on-chronic liver failure. Current corticosteroid treatments have limited efficacy, highlighting the need for new therapies. We hypothesized that outcomes are influenced by early specialized care; thus, we examined impact of time-to-tertiary care (TTTc). Methods Adults cirrhosis or advanced chronic...
Hepatic venous pressure gradient (HVPG) is a strong surrogate of severity and outcome but its relative prognostic value in metabolic dysfunction-associated steatotic liver disease (MASLD) alcohol-associated (ALD) yet to be clarified. We compared HVPG MASLD with ALD other etiologies according cirrhosis complications. In our registry RH7, we identified patients data on scrutinized them against the etiology advanced chronic (ACLD) (MASLD, ALD, Other) specific complications ACLD such as variceal...
Severe alcohol-associated hepatitis (sAH) is a well-characterized disease with high short-term mortality. However, there limited research on those "less severe condition" (moderate AH). This study aims to characterize in-depth patients moderate AH (mAH), including the performance of mortality scoring systems, key prognostic factors, and survival over time. A multicenter retrospective cohort (2009-2019) included mAH (MELD score ≤20 at admission). Cox regression receiver operating...
Liver injury associated with the use of selective androgen receptor modulators and post-cycle therapy: Two case reports literature review
Chronic liver disease management is a comprehensive approach requiring multi-professional expertise and well-orchestrated healthcare measures thoroughly organized by responsible medical units. Contextually, the corresponding multi-faceted chain of events likely to be severely disturbed or even temporarily broken under force majeure conditions such as global pandemics. Consequently, chronic highly representative for any severe disorder lasting pandemics with unprecedented numbers acutely...
Hepatocellular carcinoma (HCC) has multiple molecular classes that are associated with distinct etiologies and, besides particular characteristics, also differ in clinical aspects. We aim to characterize the aspects of alcoholic liver disease-related HCC by a retrospective observational study included all consequent patients diagnosed MRI or histologically verified participating centers from 2010 2016. A total 429 were analysis, which 412 (96%) had cirrhosis at time diagnosis. The most...
BACKGROUND:Alcohol use disorders affect 10% of the European population. Alcohol-related liver disease (ALD) is most common indication for transplantation in Slovakia. The aim this study was to determine proportion patients with ALD who received a transplant had alcohol relapsed, and risk factors relapse, as well compare clinical outcomes according relapse. MATERIAL AND METHODS:A retrospective consecutive ALD, underwent single center between May 2008 December 2017. We included adult due...
Abstract Background and aims Intestinal inflammation assessed by fecal calprotectin (F‐CAL) in advanced chronic liver disease (ACLD) may represent an early sign of intestinal barrier dysfunction. We aimed to explore the usefulness F‐CAL testing ACLD prediction adverse outcomes (AO, death, or LT) refinement prognostic stratification. Patients methods explored RH7 cirrhosis registry comprising consecutive hospitalized patients a control group with data on phenotype, demographics,...
To compare NAFLD-related HCC and other etiology-related to describe predictive factors for survival in patients with independent of the BCLC staging system. We performed a multicenter longitudinal retrospective observational study diagnosed during period from 2010 through 2016. 12.59% had HCC, 21.91% either NAFLD or cryptogenic etiology. were younger (p = 0.0007), higher proportion women < 0.001) compared patients. The group significantly lower liver cirrhosis at time diagnosis 0.0001), they...
Background and Aims: Hepatocellular cancer (HCC) often occurs in geriatric patients. The aim of our study was to compare overall survival progression-free between patients (>75 years) younger than 75 years identify predictive factors with HCC. Material Methods: We performed a retrospective analysis HCC diagnosed Slovakia 2010−2016. Cases (HCC ≥75 were matched controls <74 based on the propensity score (gender, BCLC stage first-line treatment). Results: included 148 (84 men, 57%) There no...
Abstract Background: Severe alcohol-associated hepatitis (SAH) is the most serious phenotype of liver disease (ALD) spectrum, characterized by high short-term mortality. The only approved therapy with corticosteroids (CS) has modest and survival benefits; moreover, new therapeutic alternatives are unmet need. Fecal microbiota transplantation (FMT) gained attention as a potential option for filling this gap. In study, we aimed to determine effect FMT on mortality in patients SAH beyond CS...
Summary: By analyzing 996 patients from the RH7 cirrhosis registry within 4.5 years of inclusion interval, we mapped path to liver transplantation. We found that 283 (28.4%) opened a transplant protocol with median 4 days registration, which 117 (11.7%) were placed on waiting list 91 start protocol, and 75 (7.5%) transplanted 44 enlisting. Factors increased likelihood starting younger age, better body constitution performance (BMI, muscle strength, lower frailty), autoimmune etiology,...
One of the most prevalent influenceable risk factors for poor cardiovascular outcome is arterial hypertension.This a prospective analysis liver transplant recipients in which 24-hour blood pressure (BP) measurement was performed. The primary aim to identify post-LT (liver transplantation) patients without history hypertension who meet criteria using BP monitoring. Secondary objectives were determine how many with known treated had suboptimal control. group included 88 (men, 52.3%, group:...
Abstract Rationale Severe alcohol-associated hepatitis (SAH) is the most critical, acute, inflammatory phenotype within liver disease (ALD) spectrum, characterized by high 30- and 90-day mortality. Since several decades, corticosteroids (CS) are only approved pharmacotherapy offering highly limited survival benefits. Contextually, there an evident demand for 3PM innovation in area meeting patients’ needs improving individual outcomes. Fecal microbiota transplantation (FMT) has emerged as one...
We set out to determine the applicability of acute-on-chronic liver failure (ACLF) diagnostic criteria and characteristics thus defined ACLF sub-cohorts in a real-life clinical context.Retrospective charts' analysis consecutive patients hospitalized with decompensated disease. Inclusion criteria: acute decompensation, informed consent. Exclusion malignancy. Diagnostic tools: 1st phase - CLIF-SOFA score calculated manually; 2nd CLIF-C at www.efclif.com.Of 432 aged 52 years, 41% were female,...