A5025681291- Health Systems, Economic Evaluations, Quality of Life
- Lipoproteins and Cardiovascular Health
- Atrial Fibrillation Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Cardiac Arrhythmias and Treatments
- Acute Myocardial Infarction Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Toxic Organic Pollutants Impact
- Hip and Femur Fractures
- Bone health and osteoporosis research
- Neurogenetic and Muscular Disorders Research
- Healthcare Policy and Management
- Primary Care and Health Outcomes
- Chemical Reactions and Isotopes
- Social Work Education and Practice
- Cancer Treatment and Pharmacology
- Nuclear and radioactivity studies
- Social Policy and Reform Studies
- Rare-earth and actinide compounds
- Global Cancer Incidence and Screening
- Boron and Carbon Nanomaterials Research
- Medication Adherence and Compliance
- Cancer Risks and Factors
- Retinal Development and Disorders
- Metabolism, Diabetes, and Cancer
Yerevan State University
2012-2024
Ferring Pharmaceuticals (United Kingdom)
2023
Certara (United States)
2021
Center for Ecological Noosphere Studies
2019-2021
Scientific Center of Zoology and Hydroecology
1999-2017
State University of New York
2015-2017
SUNY Downstate Health Sciences University
2015-2017
Frantsevich Institute for Problems in Materials Science
2012-2016
National Academy of Sciences of Ukraine
2012-2016
Serco (United Kingdom)
2012-2013
Alzheimer's disease (AD) and mild cognitive impairment (MCI) have negative quality of life (QoL) economic impacts on patients their caregivers may increase along the continuum from MCI to mild, moderate, severe AD.
Background Risk factors and comorbidities can complicate management of non-valvular atrial fibrillation. We describe compare real-world safety effectiveness direct oral anticoagulants (DOACs; apixaban, rivaroxaban, dabigatran) vitamin K antagonists (VKAs) in subgroups patients with fibrillation at high risk for gastrointestinal (GI) bleeding, utilizing data from a national quasi-exhaustive French database. Methods Anticoagulant-naïve adults ≥1 bleeding factor, initiating anticoagulant...
Introduction: Contemporary estimates of the impact type 2 diabetes (T2D) on stroke outcomes are important for care planning and resource allocation. This retrospective cohort study compared incidence subsequent clinical economic following among people with without T2D. Patients methods: Data were extracted from a subset French Système National des Données de Santé database. Stroke as well post-stroke outcomes, healthcare utilization (HCRU), use preventative treatments, costs Results: The...
Introduction Systemic inflammation is recognised as a critical driver of atherosclerotic cardiovascular disease (ASCVD), especially in patients with comorbid chronic kidney (CKD). This study aims to assess the prevalence systemic ASCVD population Spain. Methods Outpatient electronic medical records from The Health Improvement Network (THIN®) database were used identify and C-reactive protein (CRP) measurement ≥1 between January 2014 July 2023 proportion (defined CRP ≥ 2 mg/L) was estimated...
Abstract Introduction Data from clinical trials indicate that direct oral anticoagulants (DOACs) are noninferior and safer than conventional therapy (low-molecular-weight heparin followed by a vitamin K antagonist [VKA]) for treating venous thromboembolism (VTE), which includes deep vein thrombosis pulmonary embolism (PE). This study compared the effectiveness safety of DOACs in real-world setting. Methods observational used French national claims data adult, treatment-naïve patients...
Abstract Background People with type 2 diabetes (T2D) are at elevated risk of cardiovascular disease (CVD) including stroke, yet existing real-world evidence (RWE) on the clinical and economic burden stroke in this population is limited. The aim cohort study was to evaluate among people T2D France. Methods We conducted a retrospective RWE using data from nationally representative subset French Système National des Données de Santé (SNDS) database. assessed incidence requiring hospitalization...
Background This observational study compared effectiveness and safety of direct oral anticoagulants (DOACs; apixaban, rivaroxaban, dabigatran) or vitamin K antagonists (VKAs) in patients with non-valvular atrial fibrillation (NVAF) at high risk for gastrointestinal bleeding (GIB). Methods Anticoagulant-naïve adults NVAF ≥1 GIB factor, initiating anticoagulant treatment January 2016–December 2019, covered by the French national health data system were eligible. Outcomes included major (MB)...
To investigate whether cancer service standards are associated with survival for breast, colorectal and lung cancers at population level.Standards of hospital services in England, measured 2001, were aggregated 30 networks covering populations between 500 000 3 million people, compared 1-year 5-year relative the incident period 1996-2001, using rank correlation.Relative each showed statistically significant differences across networks. For tumour-specific services, total score 35 was longer...
OBJECTIVE Several studies have been published in 2009 suggesting a possible association between insulin glargine and increased risk of malignancies, including breast cancer. The objective this study was to assess the relation individual insulins (glargine, aspart, lispro, human insulin) development RESEARCH DESIGN AND METHODS Seven hundred seventy-five incident cases primary invasive or situ carcinoma cancer occurring women with diabetes from 92 centers U.K., Canada, France were matched mean...
Abstract Over the past decade, several drugs have been approved for treatment of relapsed or refractory multiple myeloma (RRMM). This retrospective study, using French National Healthcare database (SNDS), describes patterns and outcomes patients with RRMM treated in real-world clinical practice France. Patients were adults, a diagnosis myeloma, who initiated second-line (2L) use France between 2014 2018; this included bortezomib, carfilzomib, daratumumab, ixazomib, lenalidomide,...
In 2000, the national cancer plan for England created 34 networks, new organisational structures to coordinate services across populations varying between a half and three million people. We investigated availability of data sets reflecting measures structure, process outcome that could be used support network management. properties relating four common cancers – breast, colorectal, lung prostate. reviewed completeness these sets, identified leading items within each set put them into tables...
Background: The government set a series of targets to reduce health inequalities in England by 2010. Primary care has an important role reducing inequalities. aim the study was assess impact general practice on area-based Methods: Analysis differences achievement clinical indicators between practices Spearhead and non-Spearhead Care Trusts (PCTs) using data from Quality Outcomes Framework (QOF) for 2004/05 2005/06, characteristics status PCTs. used 8339 primary England. Unweighted mean...
Patients with cancer have an increased risk of developing venous thromboembolism (VTE) and death from VTE. Until recently, the standard care for treatment VTE in patients was low molecular weight heparins (LMWH). To determine patterns outcomes, we performed observational study using a nationwide health database. Treatment patterns, rates bleeding, recurrence at 6 12 months were assessed France prescribed LMWH 2013-2018. Of 31,771 administered (mean age 66.3 years), 51.0% male, 58.7% had...
Acid sphingomyelinase deficiency (ASMD), historically known as Niemann–Pick disease type A, A/B, and B, is a rare lysosomal storage pathology with multisystemic clinical manifestations. The aims of this study were to estimate the survival probability in patients United States chronic ASMD (ASMD types B A/B), describe characteristics these patients. This observational retrospective included medical chart records retrievable data abstracted by 69 participating physicians from 25 centers...