A5016104161- Neuropeptides and Animal Physiology
- Peptidase Inhibition and Analysis
- Neonatal Respiratory Health Research
- Galectins and Cancer Biology
- Ubiquitin and proteasome pathways
- Mesenchymal stem cell research
- Magnesium in Health and Disease
- Infant Nutrition and Health
- Cardiovascular Disease and Adiposity
- Renal function and acid-base balance
- Signaling Pathways in Disease
- Glycosylation and Glycoproteins Research
- Noise Effects and Management
- Growth Hormone and Insulin-like Growth Factors
- Neuroendocrine regulation and behavior
- Antiplatelet Therapy and Cardiovascular Diseases
- Coronary Interventions and Diagnostics
- Biochemical effects in animals
- Birth, Development, and Health
- Therapeutic Uses of Natural Elements
- Apelin-related biomedical research
H.Buniatian Institute of Biochemistry
2011-2025
National Academy of Sciences of Armenia
2011-2025
Metastatic chondrosarcoma is a bone malignancy not responsive to conventional therapies; new approaches and therapies are urgently needed. We have previously reported that mTORC1 inhibitor, antitumorigenic cytostatic proline rich polypeptide 1 (PRP-1), galarmin caused significant upregulation of tumor suppressors including TET1/2 SOCS3 (known be involved in inflammatory processes), downregulation oncoproteins embryonic stem cell marker miR-302C its targets Nanog, c-Myc Bmi-1 human...
A new type of bioactive polypeptides the neurosecretory hypothalamus called proline‑rich peptides (PRPs), which are isolated from bovine granules neurohypophysis, synthesized in form a common precursor protein (neurophysin vasopressin‑associated glycoprotein). Proline‑rich polypetide 1 (PRP‑1; also known as galarmin) is comprised 15 amino acids residues, and has been suggested to possess anti‑neurodegenerative, immunoregulatory, hematopoietic, antimicrobial antitumor properties. The...
Keywords: rat brain plasticity, prenatal immobilization stress, GFAP-, nestin-, stem cells-, PRP-1-immuno-reactive structures
Ischemic heart disease is a rather insidious condition with high mortality rate, especially in developing countries, which also affects Armenia. Therefore, the issue of most effective treatment for this particularly pressing. This will be facilitated by more thorough research on atherosclerosis arterioles. The ability to visualize and assess pathological vascular growth 5-point scale provided one modern methods using semi-thin epoxy sections stained Azure II. bioptates right atrial auricles...