A5052432894- Horticultural and Viticultural Research
- Carcinogens and Genotoxicity Assessment
- Fermentation and Sensory Analysis
- Radiation Effects and Dosimetry
- DNA Repair Mechanisms
- Chromosomal and Genetic Variations
- Genomic variations and chromosomal abnormalities
- Radiation Therapy and Dosimetry
- Environmental Toxicology and Ecotoxicology
- DNA and Nucleic Acid Chemistry
- Effects of Radiation Exposure
- Wine Industry and Tourism
- Plant Genetic and Mutation Studies
- Cancer Genomics and Diagnostics
- Radioactive contamination and transfer
- RNA Interference and Gene Delivery
- Porphyrin and Phthalocyanine Chemistry
- Chemical Reactions and Isotopes
- Genetically Modified Organisms Research
- Plant and animal studies
- Photodynamic Therapy Research Studies
- Genomics and Chromatin Dynamics
- Chronic Myeloid Leukemia Treatments
- Advanced biosensing and bioanalysis techniques
- Prenatal Screening and Diagnostics
Yerevan State University
2016-2025
Institute of Molecular Biology
2011-2021
National Academy of Sciences of Armenia
2011-2021
A.V. Dumansky Institute of Colloid and Water Chemistry
2021
Scientific Center of Zoology and Hydroecology
2021
National Polytechnic University of Armenia
2020
Armenian State Pedagogical University after Khachatur Abovian
2015-2019
Friedrich Schiller University Jena
2016
Jena University Hospital
2012-2016
Nuclear architecture studies in human sperm are sparse. By now performed ones were practically all done on flattened nuclei. Thus, close at the vivo state of sperm, i.e. three-dimensionally conserved interphase cells, lacking by now. Only position 14 chromosomes was studied.Here for first time a combination multicolor banding (MCB) and three-dimensional analysis cells used to characterize orientation healthy donor. The nuclei organized non-random way, driven gene density chromosome size.Here...
Seedlessness is a relevant trait in grapevine cultivars intended for fresh consumption or raisin production. Previous DNA marker analysis indicated that Corinto bianco (CB) parthenocarpic somatic variant of the seeded cultivar Pedro Ximenes (PX). This study compared both lines to determine basis this phenotype. At maturity, CB seedless berries were 6-fold smaller than PX berries. The macrogametophyte was absent from ovules, and also pollen sterile. Occasionally, one seed developed 1.6%...
Plant test systems are a sensitive way to detect the genetic effects of various contaminants in environmental compartments: water, soil and sediments. Biotesting genotoxicity samples with activity concentrations naturally occurring (226Ra, 232Th, 40K) artificial (137Cs) radionuclides soil, from territory Aragats Massif (Armenia) was carried out application Tradescantia micronucleus (Trad-MСN) stamen hair mutation (Trad-SHM) bioassays (clone 02) model test-object – plant system. Undisturbed...
Heterochromatic variants of pericentromere chromosome 9 are reported and discussed since decades concerning their detailed structure clinical meaning. However, studies scarce. Thus, here we provide the largest ever done molecular cytogenetic research based on >300 heteromorphism carriers.In this study, 334 carriers heterochromatic were included, being 192 patients from Western Europe remainder Easter-European origin. A 3-color-fluorescence in situ hybridization (FISH) probe-set directed...
We present the first cytogenetic data for Lebiasinabimaculata and L.melanoguttata with aim of (1) investigating evolutionary events within Lebiasina their relationships other Lebiasinidae genera (2) checking between Ctenoluciidae. Both species have a diploid number 2n = 36 similar karyotypes microsatellite distribution patterns but contrasting C-positive heterochromatin CMA3+ banding patterns. The remarkable interstitial series occurring in is absent L.bimaculata. Accordingly, L.bimaculata...
Abstract Background Whereas the complement system alterations contribute to schizophrenia, receptors and regulators are little studied. We investigated receptor type 1 (CR1) expression on blood cells, levels of circulating immune complexes (CIC) containing ligands CR1, C1q protein fragments C3 (C1q-CIC, C3d-CIC), CR1 C5507G functional polymorphism in schizophrenia patients controls. Results found an increased C1q-CIC level elevated number positive erythrocytes reduced lymphocytes monocytes...
Rapidly evolving laser technologies have led to the development of laser-generated particle accelerators as an alternative conventional facilities. However, radiobiological characteristics need be determined enhance their applications in biology and medicine. In this study, effects ultrashort pulsed electron beam (UPEB) X-ray radiation human lung fibroblasts (MRC-5 cell line) exposed doses 0.1, 0.5, 1 Gy are compared. The changes γH2AX foci number a marker DNA double-strand breaks (DSBs)...
Laser-driven accelerators allow to generate ultrashort (from femto- picoseconds) high peak dose-rate (up tens of GGy/s) accelerated particle beams. However, the radiobiological effects pulsed irradiation are still poorly studied. The aim this work was compare formation and elimination γH2AX 53BP1 foci (well known markers for DNA double-strand breaks (DSBs)) in Hela cells exposed electron beams generated by Advanced Research Electron Accelerator Laboratory (AREAL) accelerator (electron energy...
Laser-generated electron beams are distinguished from conventional accelerated particles by ultrashort beam pulses in the femtoseconds to picoseconds duration range, and their application may elucidate primary radiobiological effects. The aim of present study was determine dose-rate effect laser-generated 4 MeV radiation on DNA damage repair human cells. dose rate increased via changing pulse repetition frequency, without increasing energy. chronic myeloid leukemia K-562 cell line used...
Harmful algal blooms (HABs) are overgrowths of toxic strains algae (diatoms, green) and cyanobacteria (blue-green algae). While occurring naturally, human-induced environmental changes have resulted in more frequent occurrences such worldwide. Meantime, the ecotoxicological risk HABs is rarely evaluated by means standard test methods. For first time, genotoxic potential HAB event 2020 was assessed using two different Tradescantia-based systems (Trad-SHM Trad-MN, 24-h exposure). An integrated...
Tetrapyrrolic compounds such as porphyrins are known to be prospective chemotherapeutics and photosensitizers for cancer treatment diagnosis. In this work, water-soluble, meso-substituted cationic pyridyl-porphyrins their metallocomplexes bearing various central metal atoms ( Ag , Zn Co Fe ) in the porphine ring functional groups (allyl, oxyethyl, butyl, methallyl) at nitrogen atom pyridine were synthesized characterized by 1 H 13 C NMR UV-visible spectroscopy. Cytotoxic photodynamic...
Micronuclei (MN) can be induced by different mutagenic substances. Even though this has been known for decades, it is still not clear which genetic content, especially chromosomes, these MN are constituted of and if there any influences on content the MN-inducing substance. Also, interphase position, size, gene density a chromosome could influence its involvement in formation. To study some questions, fluorescence situ hybridization using centromeric whole-chromosome painting probes...
Micronucleus (MN) assay is a well standardized approach for evaluation of clastogenic/aneugenic effects mutagens. Fluorescence in situ hybridization (FISH) successfully used to characterize the chromosomal content MN. However, relationships between nuclear positioning, length, and gene density individual chromosomes their involvement MN induced by different mutagens have not been clearly defined.Chromosomal was characterized human leukocytes treated with mitomycin C (MMC) bleomycin (BLM)...