A5052312812- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Advanced Breast Cancer Therapies
- Statistical Methods and Inference
- PI3K/AKT/mTOR signaling in cancer
- Statistical Methods and Bayesian Inference
- Glioma Diagnosis and Treatment
- DNA Repair Mechanisms
- Phosphodiesterase function and regulation
- Brain Metastases and Treatment
- Advanced Causal Inference Techniques
- Cancer Treatment and Pharmacology
- Cancer-related Molecular Pathways
- CAR-T cell therapy research
- Cancer, Lipids, and Metabolism
- Immune Cell Function and Interaction
- Diet, Metabolism, and Disease
- Cancer Mechanisms and Therapy
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Neurological Disease Mechanisms and Treatments
- Chemokine receptors and signaling
- Bioactive Compounds and Antitumor Agents
- Ectopic Pregnancy Diagnosis and Management
Huazhong University of Science and Technology
2024
Zhejiang Medicine (China)
2023
Jiangnan University
2019-2022
Yan'an Hospital Affiliated To Kunming Medical University
2017-2022
Kunming Medical University
2017-2022
University of California, Los Angeles
2009-2020
State Key Laboratory of Food Science and Technology
2019
Jilin City Central Hospital
2016
UCLA Health
2011-2012
Genomics (United Kingdom)
2010
Abstract Metachronous liver metastases (MLM) are characterised by high incidence and mortality in clinical colorectal cancer treatment. Currently traditional methods cannot effectively predict prevent the occurrence of metachronous metastasis cancer. Based on 5hmC‐Seal analysis blood tissue samples, this study found that portal venous was more relevant to tumour gDNA than peripheral blood. We performed a novel epigenetic liquid biopsy strategy using 10 5hmC alterations, accurately...
The flavonoid quercetin holds promise as an antitumor agent in several preclinical animal models. However, the efficacy of oral administration a pancreatic cancer mouse model is unknown.The antiproliferative effects alone or combination with gemcitabine were tested 2 human cell lines using count and MTT assays. Apoptosis was evaluated by flow cytometry. Tumor growth vivo investigated orthotopic bioluminescence. Quercetin administered orally diet.Quercetin inhibited lines, which caused...
Abstract Purpose: GDC-0084 is an oral, brain-penetrant small-molecule inhibitor of PI3K and mTOR. A first-in-human, phase I study was conducted in patients with recurrent high-grade glioma. Patients Methods: administered orally, once daily, to evaluate safety, pharmacokinetics (PK), activity. Fluorodeoxyglucose-PET (FDG-PET) performed measure metabolic responses. Results: Forty-seven heavily pretreated enrolled eight cohorts (2–65 mg). Dose-limiting toxicities included 1 case grade 2...
BackgroundIt is increasingly recognized that cancer progression induces systemic immune changes in the host. Alterations number and function of cells have been identified patients' peripheral blood lymphoid organs. Recently, we found dysregulated cytokine signaling T from breast (BC) patients, even those with localized disease.MethodsWe used phosphoflow cytometry to determine clinical significance responsiveness monocytes non-metastatic BC patients at diagnosis. We also examined correlation...
Purpose: Chk1 inhibition potentiates DNA-damaging chemotherapy by overriding cell-cycle arrest and genome repair. This phase I study evaluated the inhibitor GDC-0425 given in combination with gemcitabine to patients advanced solid tumors.Experimental Design: Patients received alone for a 1-week lead-in followed 21-day cycles of plus GDC-0425. Gemcitabine was initially administered at 750 mg/m2 (Arm A), then increased 1,000 B), on days 1 8 3 + dose escalation establish maximum tolerated...
Checkpoint kinase 1 (Chk1) inhibition following chemotherapy-elicited DNA damage overrides cell cycle arrest and induces mitotic catastrophe death. GDC-0575 is a highly-selective oral small-molecule Chk1 inhibitor that results in tumor shrinkage growth delay xenograft models. We evaluated the safety, tolerability, pharmacokinetic properties of alone combination with gemcitabine. Antitumor activity pathway modulation were assessed.In this phase I open-label study, dose escalation stage,...
Telomere length (TL) has been implicated in the pathogenesis of age-related disorders. However, there are no prospective studies directly investigating role TL and relevant genes diabetes development. In multiethnic Women's Health Initiative, we identified 1,675 incident case participants 6 years follow-up 2,382 control matched by age, ethnicity, clinical center, time blood draw, duration. Leukocyte at baseline was measured using quantitative PCR, Mendelian randomization analysis conducted...
This paper develops a semiparametric Bayesian instrumental variable analysis method for estimating the causal effect of an endogenous when dealing with unobserved confounders and measurement errors partly interval-censored time-to-event data, where event times are observed exactly some subjects but left-censored, right-censored, or others. Our is based on two-stage Dirichlet process mixture (DPMIV) model which simultaneously models first-stage random error term exposure second-stage outcome...
Ellagic acid is a polyphenolic phytochemical present in many fruits and nuts with anticancer properties demonstrated experimental tumor studies. Embelin benzoquinone isolated from the Japanese herb Ardisiae Japonicae has been shown to induce apoptosis cancer cells. We found that ellagic embelin each dose-dependently increased inhibited proliferation human pancreatic cells, MIA PaCa-2 HPAF-II stellate which are progenitors of desmoplasia. In these cell types, combinations at low micromolar...
Abstract IL6 is a pleiotropic cytokine with both pro- and anti-inflammatory properties, which acts directly on cancer cells to promote their survival proliferation. Elevated serum levels negatively correlate of patients, generally attributed the direct effects cells. How modulates host immune response in patients unclear. Here, we show signaling peripheral blood T impaired breast associated blunted Th17 differentiation. The mechanism identified involved downregulation gp130 IL6Rα was...
Flavonoids have been demonstrated to cytotoxic activities toward numerous human cancer cells, whereas they little or no effect on normal cells. The flavonoids in traditional Chinese herbs may be promising candidates for the development of novel anti-cancer drugs. Our previous study that CH2Cl2 and 95% ethanol eluate (EE) fractions strongest against cell lines 9 separated from Artemisia sacrorum Ledeb., which is widely used prevent treat diverse diseases Northeast China. In present study, 8...
The dendritic cell vaccine DC-Ad-GM·CAIX is an active, specific immunotherapy with the potential of providing a safe and effective therapy against renal carcinoma (RCC). Using immunocompetent Balb/c mouse models we tested efficacy mechanism to prevent treat growth syngeneic RCC (RENCA) engineered overexpress human TAA carbonic anhydrase IX (NPR-IX). In prevention model, NPR-IX tumor development was specifically significantly delayed by 13 days in DC-Ad-GM·CAIX-treated mice (P<0.001), volumes...
Breast cancer is a heterogeneous disease and patients are managed clinically based on ER, PR, HER2 expression, key risk factors. We sought to characterize the molecular landscape of high-risk breast enrolled onto an adjuvant chemotherapy study understand how subsets tumor immune status impact survival. DNA RNA were extracted from 861 samples United States Oncology trial 01062. Samples characterized using multiplex gene copy number, qPCR mutation assays. HR+ with PIK3CA mutant had favorable...
Abstract Background: Taselisib (GDC-0032) is a next-generation PI3K inhibitor with increased anti-tumor activity against PIK3CA mutant (MT) cancers. an orally bioavailable, potent, and selective of Class I alpha, delta, gamma isoforms, 30-fold less inhibition the beta isoform relative to alpha isoform. Preclinical data show that taselisib has enhanced (PIK3CA) MT breast cancer cell lines antitumor when combined letrozole. Clinical single-agent also showed tumor shrinkage in patients as...
TPS1117 Background: In the LOTUS trial in advanced TNBC, adding IPAT to first-line PAC improved progression-free survival (PFS; primary endpoint), particularly patients (pts) with PIK3CA/AKT1/PTEN-altered tumors [Kim, Lancet Oncol 2017]. The pivotal double-blind placebo (PBO)-controlled randomized phase III IPATunity130 (NCT03337724) aims confirm and build on findings from LOTUS. Methods: Eligible pts have ECOG performance status 0/1 RECIST-measurable locally advanced/metastatic BC not...
2012 Background: GDC-0084 is a potent, oral, selective, brain-penetrant small molecule inhibitor of phosphoinositide 3-kinase (PI3K) and mammalian target rapamycin (mTOR) kinase. A first-in-human, phase 1 dose escalation study was conducted in patients with high-grade glioma. Methods: administered orally, once daily on continuous dosing schedule to evaluate the safety pharmacokinetic (PK) characteristics. Plasma samples for PK analysis were collected Day 8 or 15 Cycle 1. Fluorodeoxyglucose...
Abstract Background: MUC16 is a transmembrane protein that overexpressed by ovarian cancer. The role of in the pathogenesis cancer unknown; however, may facilitate binding tumor cells to mesothelial lining peritoneal cavity. Traditional antibody drug conjugates, with conjugation through inter-chain disulfides, are heterogeneous mixtures ratios (DAR) ranging from 0-8, resulting complex pharmacokinetics (PK) and potentially unfavorable safety efficacy. In contrast, THIOMABTM conjugates (TDCs)...
Kudingcha is implicated in alleviating metabolic disorders traditional Chinese medicine. However, the role of Kudingcha, one Ligustrum robustum species, regulations and its antitumor activity triple-negative breast cancer (TNBC) remains to be determined. Two cell lines immunocompetent immunodeficient mice were used evaluate therapeutic effects treatment. The production reactive oxygen species (ROS) glucose uptake examined by flow cytometry. Metabolic shift was metabonomics western blot...
Obesity and associated complications are becoming a pandemic. Inhibiting fatty acid synthesis elongation is an important intervention for the treatment of obesity. Despite intensive investigations, many potential therapeutic targets have yet to be discovered. In this study, decreased expression Hacd2 (a newly found enzyme in elongation) was HFD induced mice loss liver protected against obesity as well disease diabetes. Additionally, further study indicated that hepatic HACD2 deficiency...